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PubMed:20682662 JSONTXT 29 Projects

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Id Subject Object Predicate Lexical cue
T1 0-163 Sentence denotes Lack of association of C-C chemokine receptor 5 Δ32 deletion status with rheumatoid arthritis, systemic lupus erythematosus, lupus nephritis, and disease severity.
T1 0-163 Sentence denotes Lack of association of C-C chemokine receptor 5 Δ32 deletion status with rheumatoid arthritis, systemic lupus erythematosus, lupus nephritis, and disease severity.
T2 164-247 Sentence denotes OBJECTIVE: C-C chemokine receptor 5 (CCR5) plays an important role in inflammation.
T2 164-247 Sentence denotes OBJECTIVE: C-C chemokine receptor 5 (CCR5) plays an important role in inflammation.
T3 248-329 Sentence denotes A 32 base-pair (Δ32) deletion in the CCR5 gene leads to a nonfunctional receptor.
T3 248-329 Sentence denotes A 32 base-pair (Δ32) deletion in the CCR5 gene leads to a nonfunctional receptor.
T4 330-456 Sentence denotes This deletion has been reported to have a protective effect on the development and progression of several autoimmune diseases.
T4 330-456 Sentence denotes This deletion has been reported to have a protective effect on the development and progression of several autoimmune diseases.
T5 457-713 Sentence denotes We investigated whether the Δ32 deletion is associated with disease susceptibility in a population of patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and lupus nephritis (LN); and whether it is associated with disease severity.
T5 457-713 Sentence denotes We investigated whether the Δ32 deletion is associated with disease susceptibility in a population of patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and lupus nephritis (LN); and whether it is associated with disease severity.
T6 714-857 Sentence denotes METHODS: DNA samples from 405 RA patients, 97 SLE patients, 113 LN patients, and 431 healthy controls were genotyped for the CCR5 Δ32 deletion.
T6 714-857 Sentence denotes METHODS: DNA samples from 405 RA patients, 97 SLE patients, 113 LN patients, and 431 healthy controls were genotyped for the CCR5 Δ32 deletion.
T7 858-936 Sentence denotes Differences in genotype frequencies were tested between patients and controls.
T7 858-936 Sentence denotes Differences in genotype frequencies were tested between patients and controls.
T8 937-997 Sentence denotes Association of genotypes with disease severity was analyzed.
T8 937-997 Sentence denotes Association of genotypes with disease severity was analyzed.
T9 998-1006 Sentence denotes RESULTS:
T9 998-1006 Sentence denotes RESULTS:
T10 1007-1077 Sentence denotes Genotype frequencies of each group were in Hardy-Weinberg equilibrium.
T10 1007-1077 Sentence denotes Genotype frequencies of each group were in Hardy-Weinberg equilibrium.
T11 1078-1275 Sentence denotes The genotype frequencies of patients did not differ significantly from controls (CCR5/Δ32, Δ32/Δ32: RA 18.3% and 1.2%, respectively; SLE 17.5% and 2.1%; LN 13.3% and 1.8%; controls 20.0% and 2.8%).
T11 1078-1275 Sentence denotes The genotype frequencies of patients did not differ significantly from controls (CCR5/Δ32, Δ32/Δ32: RA 18.3% and 1.2%, respectively; SLE 17.5% and 2.1%; LN 13.3% and 1.8%; controls 20.0% and 2.8%).
T12 1276-1390 Sentence denotes However, there was a trend for lower Δ32 deletion allele frequency in LN patients compared to controls (p = 0.08).
T12 1276-1390 Sentence denotes However, there was a trend for lower Δ32 deletion allele frequency in LN patients compared to controls (p = 0.08).
T13 1391-1491 Sentence denotes There was no significant association between the CCR5 status and disease severity in RA, SLE, or LN.
T13 1391-1491 Sentence denotes There was no significant association between the CCR5 status and disease severity in RA, SLE, or LN.
T14 1492-1503 Sentence denotes CONCLUSION:
T14 1492-1503 Sentence denotes CONCLUSION:
T15 1504-1651 Sentence denotes Although an association with LN cannot be excluded, the CCR5 Δ32 deletion does not seem to be a disease susceptibility genotype for RA, SLE, or LN.
T15 1504-1651 Sentence denotes Although an association with LN cannot be excluded, the CCR5 Δ32 deletion does not seem to be a disease susceptibility genotype for RA, SLE, or LN.
T16 1652-1731 Sentence denotes No significant effect of the Δ32 deletion on disease severity was demonstrated.
T16 1652-1731 Sentence denotes No significant effect of the Δ32 deletion on disease severity was demonstrated.