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PubMed:20367798 JSONTXT 6 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-56 Sentence denotes Association between idiopathic achalasia and IL23R gene.
T1 0-56 Sentence denotes Association between idiopathic achalasia and IL23R gene.
T2 57-68 Sentence denotes BACKGROUND:
T2 57-68 Sentence denotes BACKGROUND:
T3 69-149 Sentence denotes Idiopathic achalasia is a primary esophageal motor disorder of unknown etiology.
T3 69-149 Sentence denotes Idiopathic achalasia is a primary esophageal motor disorder of unknown etiology.
T4 150-299 Sentence denotes Different evidences have been reported in support of achalasia as the result of an autoimmune and inflammatory process leading to neuronal cell loss.
T4 150-299 Sentence denotes Different evidences have been reported in support of achalasia as the result of an autoimmune and inflammatory process leading to neuronal cell loss.
T5 300-533 Sentence denotes According to this, idiopathic achalasia has been significantly associated with specific alleles of the human leukocyte antigen system class II, although few reports studying association with other loci can be found in the literature.
T5 300-533 Sentence denotes According to this, idiopathic achalasia has been significantly associated with specific alleles of the human leukocyte antigen system class II, although few reports studying association with other loci can be found in the literature.
T6 534-704 Sentence denotes Recent studies have shown association of a non-synonymous polymorphism within the IL23R gene with different chronic inflammatory disorders, including Barrett's esophagus.
T6 534-704 Sentence denotes Recent studies have shown association of a non-synonymous polymorphism within the IL23R gene with different chronic inflammatory disorders, including Barrett's esophagus.
T7 705-855 Sentence denotes The purpose of this study was to assess whether the IL23R coding variant Arg381Gln polymorphism is involved in susceptibility to idiopathic achalasia.
T7 705-855 Sentence denotes The purpose of this study was to assess whether the IL23R coding variant Arg381Gln polymorphism is involved in susceptibility to idiopathic achalasia.
T8 856-864 Sentence denotes METHODS:
T8 856-864 Sentence denotes METHODS:
T9 865-1002 Sentence denotes We performed a case-control study including 262 patients with idiopathic achalasia and 802 healthy subjects, all of them white Spaniards.
T9 865-1002 Sentence denotes We performed a case-control study including 262 patients with idiopathic achalasia and 802 healthy subjects, all of them white Spaniards.
T10 1003-1113 Sentence denotes Achalasia patients were diagnosed on the basis of clinical, radiographic, endoscopic, and manometric criteria.
T10 1003-1113 Sentence denotes Achalasia patients were diagnosed on the basis of clinical, radiographic, endoscopic, and manometric criteria.
T11 1114-1202 Sentence denotes All samples were genotyped for the IL23R Arg381Gln polymorphism using TaqMan technology.
T11 1114-1202 Sentence denotes All samples were genotyped for the IL23R Arg381Gln polymorphism using TaqMan technology.
T12 1203-1215 Sentence denotes KEY RESULTS:
T12 1203-1215 Sentence denotes KEY RESULTS:
T13 1216-1377 Sentence denotes The minor allele of the Arg381Gln polymorphism was significantly increased in patients compared with healthy controls (OR = 1.46, 95% CI = 1.01-2.11, P = 0.036).
T13 1216-1377 Sentence denotes The minor allele of the Arg381Gln polymorphism was significantly increased in patients compared with healthy controls (OR = 1.46, 95% CI = 1.01-2.11, P = 0.036).
T14 1378-1510 Sentence denotes This association seems to be specific to male patients with disease onset after 40 years (OR = 2.33, 95% CI = 1.29-4.16, P = 0.002).
T14 1378-1510 Sentence denotes This association seems to be specific to male patients with disease onset after 40 years (OR = 2.33, 95% CI = 1.29-4.16, P = 0.002).
T15 1511-1536 Sentence denotes CONCLUSIONS & INFERENCES:
T15 1511-1536 Sentence denotes CONCLUSIONS & INFERENCES:
T16 1537-1714 Sentence denotes Our results suggest a role of IL23R in idiopathic achalasia predisposition and extend the evidence of the general influence of this gene in autoimmune and inflammatory diseases.
T16 1537-1714 Sentence denotes Our results suggest a role of IL23R in idiopathic achalasia predisposition and extend the evidence of the general influence of this gene in autoimmune and inflammatory diseases.