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PubMed:20117337 JSONTXT 6 Projects

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Id Subject Object Predicate Lexical cue
T1 0-50 Sentence denotes Defensin-immunology in inflammatory bowel disease.
T1 0-50 Sentence denotes Defensin-immunology in inflammatory bowel disease.
T2 51-203 Sentence denotes Defensins are endogenous antibiotics with microbicidal activity against Gram-negative and Gram-positive bacteria, fungi, enveloped viruses and protozoa.
T2 51-203 Sentence denotes Defensins are endogenous antibiotics with microbicidal activity against Gram-negative and Gram-positive bacteria, fungi, enveloped viruses and protozoa.
T3 204-380 Sentence denotes A disturbed antimicrobial defense, as provided by Paneth- and other epithelial cell defensins, seems to be a critical factor in the pathogenesis of inflammatory bowel diseases.
T3 204-380 Sentence denotes A disturbed antimicrobial defense, as provided by Paneth- and other epithelial cell defensins, seems to be a critical factor in the pathogenesis of inflammatory bowel diseases.
T4 381-602 Sentence denotes Conspicuously, there is a relative lack of Paneth cell beta-defensins HD-5 and HD-6 in ileal Crohn's disease, both in the absence of a pattern recognition receptor NOD2 mutation and, even more pronounced, in its presence.
T4 381-602 Sentence denotes Conspicuously, there is a relative lack of Paneth cell beta-defensins HD-5 and HD-6 in ileal Crohn's disease, both in the absence of a pattern recognition receptor NOD2 mutation and, even more pronounced, in its presence.
T5 603-729 Sentence denotes This deficit is independent of concurrent active inflammation and results in a diminished antibacterial killing by the mucosa.
T5 603-729 Sentence denotes This deficit is independent of concurrent active inflammation and results in a diminished antibacterial killing by the mucosa.
T6 730-927 Sentence denotes The Crohn's disease mucosa has not only a significant lack in killing different Escherichia coli but also an impaired ability in clearing Staphylococcus aureus as well as anaerobic micro-organisms.
T6 730-927 Sentence denotes The Crohn's disease mucosa has not only a significant lack in killing different Escherichia coli but also an impaired ability in clearing Staphylococcus aureus as well as anaerobic micro-organisms.
T7 928-1045 Sentence denotes Thus, this dysfunction in antibacterial barrier seems to be broad and is not restricted to a single bacterial strain.
T7 928-1045 Sentence denotes Thus, this dysfunction in antibacterial barrier seems to be broad and is not restricted to a single bacterial strain.
T8 1046-1181 Sentence denotes In addition to directly controlling barrier function, Paneth cell defensins also regulate the composition of the bacterial stool flora.
T8 1046-1181 Sentence denotes In addition to directly controlling barrier function, Paneth cell defensins also regulate the composition of the bacterial stool flora.
T9 1182-1348 Sentence denotes In the majority of patients, the Paneth cell deficiency is mediated by WNT signalling which suggests a disturbed Paneth cell differentiation in ileal Crohn's disease.
T9 1182-1348 Sentence denotes In the majority of patients, the Paneth cell deficiency is mediated by WNT signalling which suggests a disturbed Paneth cell differentiation in ileal Crohn's disease.
T10 1349-1521 Sentence denotes In contrast, colonic Crohn's disease is characterised by an impaired induction of mucosal beta-defensins, partly due to a low copy number of the beta-defensin gene cluster.
T10 1349-1521 Sentence denotes In contrast, colonic Crohn's disease is characterised by an impaired induction of mucosal beta-defensins, partly due to a low copy number of the beta-defensin gene cluster.
T11 1522-1621 Sentence denotes Therefore it seems plausible that bacteria take advantage of a niche formed by defensin deficiency.
T11 1522-1621 Sentence denotes Therefore it seems plausible that bacteria take advantage of a niche formed by defensin deficiency.
T12 1622-1749 Sentence denotes This would represent a paradigm shift in understanding Crohn's disease and provides a target for future therapeutic strategies.
T12 1622-1749 Sentence denotes This would represent a paradigm shift in understanding Crohn's disease and provides a target for future therapeutic strategies.