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PubMed:19749203 JSONTXT 61 Projects

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Id Subject Object Predicate Lexical cue
T1 0-105 Sentence denotes Mammalian cell ganglioside-binding specificities of E. coli enterotoxins LT-IIb and variant LT-IIb(T13I).
T1 0-105 Sentence denotes Mammalian cell ganglioside-binding specificities of E. coli enterotoxins LT-IIb and variant LT-IIb(T13I).
T2 106-250 Sentence denotes LT-IIb, a type II heat-labile enterotoxin of Escherichia coli, is a potent immunologic adjuvant with high affinity binding for ganglioside GD1a.
T2 106-250 Sentence denotes LT-IIb, a type II heat-labile enterotoxin of Escherichia coli, is a potent immunologic adjuvant with high affinity binding for ganglioside GD1a.
T3 251-369 Sentence denotes Earlier study suggested that LT-IIb bound preferentially to the terminal sugar sequence NeuAcalpha2-3Galbeta1-3GalNAc.
T3 251-369 Sentence denotes Earlier study suggested that LT-IIb bound preferentially to the terminal sugar sequence NeuAcalpha2-3Galbeta1-3GalNAc.
T4 370-450 Sentence denotes However, studies in our laboratory suggested a less restrictive binding epitope.
T4 370-450 Sentence denotes However, studies in our laboratory suggested a less restrictive binding epitope.
T5 451-613 Sentence denotes LT-IIb(T13I), an LT-IIb variant, engineered by a single isoleucine-threonine substitution, retains biological activity, but with less robust inflammatory effects.
T5 451-613 Sentence denotes LT-IIb(T13I), an LT-IIb variant, engineered by a single isoleucine-threonine substitution, retains biological activity, but with less robust inflammatory effects.
T6 614-823 Sentence denotes We theorized that LT-IIb has a less restrictive binding epitope than previously proposed and that immunologic differences between LT-IIb and LT-IIb (T13I) correlate with subtle ganglioside binding differences.
T6 614-823 Sentence denotes We theorized that LT-IIb has a less restrictive binding epitope than previously proposed and that immunologic differences between LT-IIb and LT-IIb (T13I) correlate with subtle ganglioside binding differences.
T7 824-1067 Sentence denotes Ganglioside binding epitopes, determined by affinity overlay immunoblotting and enzymatic degradation of ganglioside components of RAW264.7 macrophages, indicated that LT-IIb bound to a broader array of gangliosides than previously recognized.
T7 824-1067 Sentence denotes Ganglioside binding epitopes, determined by affinity overlay immunoblotting and enzymatic degradation of ganglioside components of RAW264.7 macrophages, indicated that LT-IIb bound to a broader array of gangliosides than previously recognized.
T8 1068-1162 Sentence denotes Each possessed NeuAcalpha2-3Galbeta1-3GalNAc, although not necessarily as a terminal sequence.
T8 1068-1162 Sentence denotes Each possessed NeuAcalpha2-3Galbeta1-3GalNAc, although not necessarily as a terminal sequence.
T9 1163-1287 Sentence denotes Rather, each had a requisite terminal or penultimate single sialic acid and binding was independent of ceramide composition.
T9 1163-1287 Sentence denotes Rather, each had a requisite terminal or penultimate single sialic acid and binding was independent of ceramide composition.
T10 1288-1462 Sentence denotes RAW264.7 enterotoxin-binding and non-binding ganglioside epitopes were definitively identified as GD1a and GM1a, respectively, by enzymatic degradation and mass spectroscopy.
T10 1288-1462 Sentence denotes RAW264.7 enterotoxin-binding and non-binding ganglioside epitopes were definitively identified as GD1a and GM1a, respectively, by enzymatic degradation and mass spectroscopy.
T11 1463-1679 Sentence denotes Affinity overlay immunoblots, constructed to the diverse array of known ganglioside structures of murine peritoneal macrophages, established that LT-IIb bound NeuAc- and NeuGc-gangliosides with nearly equal affinity.
T11 1463-1679 Sentence denotes Affinity overlay immunoblots, constructed to the diverse array of known ganglioside structures of murine peritoneal macrophages, established that LT-IIb bound NeuAc- and NeuGc-gangliosides with nearly equal affinity.
T12 1680-1782 Sentence denotes However, LT-IIb(T13I) exhibited enhanced affinity for NeuGc-gangliosides and more restrictive binding.
T12 1680-1782 Sentence denotes However, LT-IIb(T13I) exhibited enhanced affinity for NeuGc-gangliosides and more restrictive binding.
T13 1783-1969 Sentence denotes These studies further elucidate the binding epitope for LT-IIb and suggest that the diminished inflammatory activity of LT-IIb(T13I) is mediated by a subtle shift in ganglioside binding.
T13 1783-1969 Sentence denotes These studies further elucidate the binding epitope for LT-IIb and suggest that the diminished inflammatory activity of LT-IIb(T13I) is mediated by a subtle shift in ganglioside binding.
T14 1970-2072 Sentence denotes These studies underscore the high degree of specificity required for ganglioside-protein interactions.
T14 1970-2072 Sentence denotes These studies underscore the high degree of specificity required for ganglioside-protein interactions.