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PubMed:19748975 JSONTXT 65 Projects

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Id Subject Object Predicate Lexical cue
T1 0-92 Sentence denotes Glycan gimmickry by parasitic helminths: a strategy for modulating the host immune response?
T1 0-92 Sentence denotes Glycan gimmickry by parasitic helminths: a strategy for modulating the host immune response?
T2 93-219 Sentence denotes Parasitic helminths (worms) co-evolved with vertebrate immune systems to enable long-term survival of worms in infected hosts.
T2 93-219 Sentence denotes Parasitic helminths (worms) co-evolved with vertebrate immune systems to enable long-term survival of worms in infected hosts.
T3 220-446 Sentence denotes Among their survival strategies, worms use their glycans within glycoproteins and glycolipids, which are abundant on helminth surfaces and in their excretory/ secretory products, to regulate and suppress host immune responses.
T3 220-446 Sentence denotes Among their survival strategies, worms use their glycans within glycoproteins and glycolipids, which are abundant on helminth surfaces and in their excretory/ secretory products, to regulate and suppress host immune responses.
T4 447-647 Sentence denotes Many helminths express unusual and antigenic (nonhost-like) glycans, including those containing polyfucose, tyvelose, terminal GalNAc, phosphorylcholine, methyl groups, and sugars in unusual linkages.
T4 447-647 Sentence denotes Many helminths express unusual and antigenic (nonhost-like) glycans, including those containing polyfucose, tyvelose, terminal GalNAc, phosphorylcholine, methyl groups, and sugars in unusual linkages.
T5 648-963 Sentence denotes In addition, some glycan antigens are expressed that share structural features with those in their intermediate and vertebrate hosts (host-like glycans), including Le(X) (Galbeta1-4[Fucalpha1-3]GlcNAc-), LDNF (GalNAcbeta1-4[Fucalpha1-3]GlcNAc-), LDN (GalNAcbeta1-4GlcNAc-), and Tn (GalNAcalpha1-O-Thr/Ser) antigens.
T5 648-963 Sentence denotes In addition, some glycan antigens are expressed that share structural features with those in their intermediate and vertebrate hosts (host-like glycans), including Le(X) (Galbeta1-4[Fucalpha1-3]GlcNAc-), LDNF (GalNAcbeta1-4[Fucalpha1-3]GlcNAc-), LDN (GalNAcbeta1-4GlcNAc-), and Tn (GalNAcalpha1-O-Thr/Ser) antigens.
T6 964-1103 Sentence denotes The expression of host-like glycan determinants is remarkable and suggests that helminths may gain advantages by synthesizing such glycans.
T6 964-1103 Sentence denotes The expression of host-like glycan determinants is remarkable and suggests that helminths may gain advantages by synthesizing such glycans.
T7 1104-1336 Sentence denotes The expression of host-like glycans by parasites previously led to the concept of "molecular mimicry," in which molecules are either derived from the pathogen or acquired from the host to evade recognition by the host immune system.
T7 1104-1336 Sentence denotes The expression of host-like glycans by parasites previously led to the concept of "molecular mimicry," in which molecules are either derived from the pathogen or acquired from the host to evade recognition by the host immune system.
T8 1337-1557 Sentence denotes However, recent discoveries into the potential of host glycan-binding proteins (GBPs), such as C-type lectin receptors and galectins, to functionally interact with various host-like helminth glycans provide new insights.
T8 1337-1557 Sentence denotes However, recent discoveries into the potential of host glycan-binding proteins (GBPs), such as C-type lectin receptors and galectins, to functionally interact with various host-like helminth glycans provide new insights.
T9 1558-1696 Sentence denotes Host GBPs through their interactions with worm-derived glycans participate in shaping innate and adaptive immune responses upon infection.
T9 1558-1696 Sentence denotes Host GBPs through their interactions with worm-derived glycans participate in shaping innate and adaptive immune responses upon infection.
T10 1697-1893 Sentence denotes We thus propose an alternative concept termed "glycan gimmickry," which is defined as an active strategy of parasites to use their glycans to target GBPs within the host to promote their survival.
T10 1697-1893 Sentence denotes We thus propose an alternative concept termed "glycan gimmickry," which is defined as an active strategy of parasites to use their glycans to target GBPs within the host to promote their survival.