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PubMed:19435888 JSONTXT 40 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-110 Sentence denotes Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein.
T1 0-110 Sentence denotes Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein.
T2 111-246 Sentence denotes Mouse models have shown the importance of acidic mammalian chitinase activity in settings of chitin exposure and allergic inflammation.
T2 111-246 Sentence denotes Mouse models have shown the importance of acidic mammalian chitinase activity in settings of chitin exposure and allergic inflammation.
T3 247-357 Sentence denotes However, little is known regarding genetic regulation of AMCase enzymatic activity in human allergic diseases.
T3 247-357 Sentence denotes However, little is known regarding genetic regulation of AMCase enzymatic activity in human allergic diseases.
T4 358-593 Sentence denotes Resequencing the AMCase gene exons we identified 8 non-synonymous single nucleotide polymorphisms including three novel variants (A290G, G296A, G339T) near the gene area coding for the enzyme active site, all in linkage disequilibrium.
T4 358-593 Sentence denotes Resequencing the AMCase gene exons we identified 8 non-synonymous single nucleotide polymorphisms including three novel variants (A290G, G296A, G339T) near the gene area coding for the enzyme active site, all in linkage disequilibrium.
T5 594-765 Sentence denotes AMCase protein isoforms, encoded by two gene-wide haplotypes, and differentiated by these three single nucleotide polymorphisms, were recombinantly expressed and purified.
T5 594-765 Sentence denotes AMCase protein isoforms, encoded by two gene-wide haplotypes, and differentiated by these three single nucleotide polymorphisms, were recombinantly expressed and purified.
T6 766-954 Sentence denotes Biochemical analysis revealed the isoform encoded by the variant haplotype displayed a distinct pH profile exhibiting greater retention of chitinase activity at acidic and basic pH values.
T6 766-954 Sentence denotes Biochemical analysis revealed the isoform encoded by the variant haplotype displayed a distinct pH profile exhibiting greater retention of chitinase activity at acidic and basic pH values.
T7 955-1167 Sentence denotes Determination of absolute kinetic activity found the variant isoform encoded by the variant haplotype was 4-, 2.5-, and 10-fold more active than the wild type AMCase isoform at pH 2.2, 4.6, and 7.0, respectively.
T7 955-1167 Sentence denotes Determination of absolute kinetic activity found the variant isoform encoded by the variant haplotype was 4-, 2.5-, and 10-fold more active than the wild type AMCase isoform at pH 2.2, 4.6, and 7.0, respectively.
T8 1168-1298 Sentence denotes Modeling of the AMCase isoforms revealed positional changes in amino acids critical for both pH specificity and substrate binding.
T8 1168-1298 Sentence denotes Modeling of the AMCase isoforms revealed positional changes in amino acids critical for both pH specificity and substrate binding.
T9 1299-1461 Sentence denotes Genetic association analyses of AMCase haplotypes for asthma revealed significant protective associations between the variant haplotype in several asthma cohorts.
T9 1299-1461 Sentence denotes Genetic association analyses of AMCase haplotypes for asthma revealed significant protective associations between the variant haplotype in several asthma cohorts.
T10 1462-1663 Sentence denotes The structural, kinetic, and genetic data regarding the AMCase isoforms are consistent with the Th2-priming effects of environmental chitin and a role for AMCase in negatively regulating this stimulus.
T10 1462-1663 Sentence denotes The structural, kinetic, and genetic data regarding the AMCase isoforms are consistent with the Th2-priming effects of environmental chitin and a role for AMCase in negatively regulating this stimulus.