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PubMed:19099590 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
T1 0-95 Sentence denotes Genetic polymorphisms of RANTES, IL1-A, MCP-1 and TNF-A genes in patients with prostate cancer.
T1 0-95 Sentence denotes Genetic polymorphisms of RANTES, IL1-A, MCP-1 and TNF-A genes in patients with prostate cancer.
T2 96-107 Sentence denotes BACKGROUND:
T2 96-107 Sentence denotes BACKGROUND:
T3 108-218 Sentence denotes Inflammation has been implicated as an etiological factor in several human cancers, including prostate cancer.
T3 108-218 Sentence denotes Inflammation has been implicated as an etiological factor in several human cancers, including prostate cancer.
T4 219-354 Sentence denotes Allelic variants of the genes involved in inflammatory pathways are logical candidates as genetic determinants of prostate cancer risk.
T4 219-354 Sentence denotes Allelic variants of the genes involved in inflammatory pathways are logical candidates as genetic determinants of prostate cancer risk.
T5 355-578 Sentence denotes The purpose of this study was to investigate whether single nucleotide polymorphisms of genes that lead to increased levels of pro-inflammatory cytokines and chemokines are associated with an increased prostate cancer risk.
T5 355-578 Sentence denotes The purpose of this study was to investigate whether single nucleotide polymorphisms of genes that lead to increased levels of pro-inflammatory cytokines and chemokines are associated with an increased prostate cancer risk.
T6 579-587 Sentence denotes METHODS:
T6 579-587 Sentence denotes METHODS:
T7 588-910 Sentence denotes A case-control study design was used to test the association between prostate cancer risk and the polymorphisms TNF-A-308 A/G (rs 1800629), RANTES-403 G/A (rs 2107538), IL1-A-889 C/T (rs 1800587) and MCP-1 2518 G/A (rs 1024611) in 296 patients diagnosed with prostate cancer and in 311 healthy controls from the same area.
T7 588-910 Sentence denotes A case-control study design was used to test the association between prostate cancer risk and the polymorphisms TNF-A-308 A/G (rs 1800629), RANTES-403 G/A (rs 2107538), IL1-A-889 C/T (rs 1800587) and MCP-1 2518 G/A (rs 1024611) in 296 patients diagnosed with prostate cancer and in 311 healthy controls from the same area.
T8 911-919 Sentence denotes RESULTS:
T8 911-919 Sentence denotes RESULTS:
T9 920-1094 Sentence denotes Diagnosis of prostate cancer was significantly associated with TNF-A GA + AA genotype (OR, 1.61; 95% CI, 1.09-2.64) and RANTES GA + AA genotype (OR, 1.44; 95% CI, 1.09-2.38).
T9 920-1094 Sentence denotes Diagnosis of prostate cancer was significantly associated with TNF-A GA + AA genotype (OR, 1.61; 95% CI, 1.09-2.64) and RANTES GA + AA genotype (OR, 1.44; 95% CI, 1.09-2.38).
T10 1095-1223 Sentence denotes A alleles in TNF-A and RANTES influenced prostate cancer susceptibility and acted independently of each other in these subjects.
T10 1095-1223 Sentence denotes A alleles in TNF-A and RANTES influenced prostate cancer susceptibility and acted independently of each other in these subjects.
T11 1224-1309 Sentence denotes No epistatic effect was found for the combination of different polymorphisms studied.
T11 1224-1309 Sentence denotes No epistatic effect was found for the combination of different polymorphisms studied.
T12 1310-1414 Sentence denotes Finally, no overall association was found between prostate cancer risk and IL1-A or MCP-1 polymorphisms.
T12 1310-1414 Sentence denotes Finally, no overall association was found between prostate cancer risk and IL1-A or MCP-1 polymorphisms.
T13 1415-1426 Sentence denotes CONCLUSION:
T13 1415-1426 Sentence denotes CONCLUSION:
T14 1427-1629 Sentence denotes Our results and previously published findings on genes associated with innate immunity support the hypothesis that polymorphisms in proinflammatory genes may be important in prostate cancer development.
T14 1427-1629 Sentence denotes Our results and previously published findings on genes associated with innate immunity support the hypothesis that polymorphisms in proinflammatory genes may be important in prostate cancer development.