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PubMed:18854367 JSONTXT 51 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-65 Sentence denotes Hyaluronan receptors involved in cytokine induction in monocytes.
T1 0-65 Sentence denotes Hyaluronan receptors involved in cytokine induction in monocytes.
T2 66-206 Sentence denotes During inflammation, lower molecular weight fragments of hyaluronan accumulate, and this is known to be inflammatory and immune-stimulatory.
T2 66-206 Sentence denotes During inflammation, lower molecular weight fragments of hyaluronan accumulate, and this is known to be inflammatory and immune-stimulatory.
T3 207-441 Sentence denotes In diseases such as inflammatory bowel disease, inflammatory cells bind to hyaluronan; however, the cellular response and molecular mechanism of hyaluronan-hyaluronan receptor interactions in mononuclear cells are not well understood.
T3 207-441 Sentence denotes In diseases such as inflammatory bowel disease, inflammatory cells bind to hyaluronan; however, the cellular response and molecular mechanism of hyaluronan-hyaluronan receptor interactions in mononuclear cells are not well understood.
T4 442-539 Sentence denotes The expression of hyaluronan receptors in peripheral blood mononuclear cells (PBMC) was examined.
T4 442-539 Sentence denotes The expression of hyaluronan receptors in peripheral blood mononuclear cells (PBMC) was examined.
T5 540-830 Sentence denotes PBMC were stimulated with lower and higher molecular weight hyaluronan (molecular weight 100-150 kDa and 2700 kDa) and the induction of proinflammatory cytokines (interleukin-6 (IL-6) and monocyte chemoattractant protein (MCP-1)) was compared by enzyme-linked immunoabsorbant assay (ELISA).
T5 540-830 Sentence denotes PBMC were stimulated with lower and higher molecular weight hyaluronan (molecular weight 100-150 kDa and 2700 kDa) and the induction of proinflammatory cytokines (interleukin-6 (IL-6) and monocyte chemoattractant protein (MCP-1)) was compared by enzyme-linked immunoabsorbant assay (ELISA).
T6 831-896 Sentence denotes Cells were coincubated with various signaling pathway inhibitors.
T6 831-896 Sentence denotes Cells were coincubated with various signaling pathway inhibitors.
T7 897-1009 Sentence denotes In addition, neutralizing antibodies against CD44 and TLR4 were added and the effects on PBMC were investigated.
T7 897-1009 Sentence denotes In addition, neutralizing antibodies against CD44 and TLR4 were added and the effects on PBMC were investigated.
T8 1010-1156 Sentence denotes Finally, mononuclear cells from CD44-null and toll-like receptor 4 (TLR4) mutant mice were both stimulated with lower molecular weight hyaluronan.
T8 1010-1156 Sentence denotes Finally, mononuclear cells from CD44-null and toll-like receptor 4 (TLR4) mutant mice were both stimulated with lower molecular weight hyaluronan.
T9 1157-1235 Sentence denotes Among the hyaluronan receptors, TLR4 and CD44 were markedly expressed on PBMC.
T9 1157-1235 Sentence denotes Among the hyaluronan receptors, TLR4 and CD44 were markedly expressed on PBMC.
T10 1236-1315 Sentence denotes Hyaluronan-stimulated PBMC enhanced the attachment to the extracellular matrix.
T10 1236-1315 Sentence denotes Hyaluronan-stimulated PBMC enhanced the attachment to the extracellular matrix.
T11 1316-1471 Sentence denotes Lower molecular weight hyaluronan induced IL-6 and MCP-1 production in PBMC, but high-molecular-weight hyaluronan did not induce IL-6 and MCP-1 production.
T11 1316-1471 Sentence denotes Lower molecular weight hyaluronan induced IL-6 and MCP-1 production in PBMC, but high-molecular-weight hyaluronan did not induce IL-6 and MCP-1 production.
T12 1472-1595 Sentence denotes An anti-CD44 antibody attenuated the induction of both IL-6 and MCP-1 in lower molecular weight hyaluronan-stimulated PBMC.
T12 1472-1595 Sentence denotes An anti-CD44 antibody attenuated the induction of both IL-6 and MCP-1 in lower molecular weight hyaluronan-stimulated PBMC.
T13 1596-1721 Sentence denotes In both TLR4 mutant and CD44-null mice, the induction of IL-6 by lower molecular weight hyaluronan stimulation was decreased.
T13 1596-1721 Sentence denotes In both TLR4 mutant and CD44-null mice, the induction of IL-6 by lower molecular weight hyaluronan stimulation was decreased.
T14 1722-1892 Sentence denotes SB203580 completely abolished IL-6 production in both TLR4 mutant and CD44-null mononuclear cells, while PD98059 abolished IL-6 production in CD44-null mononuclear cells.
T14 1722-1892 Sentence denotes SB203580 completely abolished IL-6 production in both TLR4 mutant and CD44-null mononuclear cells, while PD98059 abolished IL-6 production in CD44-null mononuclear cells.
T15 1893-2015 Sentence denotes Hyaluronan receptors, CD44 and TLR4, play distinct roles in cytokine induction in hyaluronan-stimulated mononuclear cells.
T15 1893-2015 Sentence denotes Hyaluronan receptors, CD44 and TLR4, play distinct roles in cytokine induction in hyaluronan-stimulated mononuclear cells.