| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-154 |
Sentence |
denotes |
Exaggerated expression of inflammatory mediators in vasoactive intestinal polypeptide knockout (VIP-/-) mice with cyclophosphamide (CYP)-induced cystitis. |
| T1 |
0-154 |
Sentence |
denotes |
Exaggerated expression of inflammatory mediators in vasoactive intestinal polypeptide knockout (VIP-/-) mice with cyclophosphamide (CYP)-induced cystitis. |
| T2 |
155-267 |
Sentence |
denotes |
Vasoactive intestinal polypeptide (VIP) is an immunomodulatory neuropeptide distributed in micturition pathways. |
| T2 |
155-267 |
Sentence |
denotes |
Vasoactive intestinal polypeptide (VIP) is an immunomodulatory neuropeptide distributed in micturition pathways. |
| T3 |
268-414 |
Sentence |
denotes |
VIP(-/-) mice exhibit altered bladder function and neurochemical properties in micturition pathways after cyclophosphamide (CYP)-induced cystitis. |
| T3 |
268-414 |
Sentence |
denotes |
VIP(-/-) mice exhibit altered bladder function and neurochemical properties in micturition pathways after cyclophosphamide (CYP)-induced cystitis. |
| T4 |
415-572 |
Sentence |
denotes |
Given VIP's role as an anti-inflammatory mediator, we hypothesized that VIP(-/-) mice would exhibit enhanced inflammatory mediator expression after cystitis. |
| T4 |
415-572 |
Sentence |
denotes |
Given VIP's role as an anti-inflammatory mediator, we hypothesized that VIP(-/-) mice would exhibit enhanced inflammatory mediator expression after cystitis. |
| T5 |
573-799 |
Sentence |
denotes |
A mouse inflammatory cytokine and receptor RT2 profiler array was used to determine regulated transcripts in the urinary bladder of wild type (WT) and VIP(-/-) mice with or without CYP-induced cystitis (150 mg/kg; i.p.; 48 h). |
| T5 |
573-799 |
Sentence |
denotes |
A mouse inflammatory cytokine and receptor RT2 profiler array was used to determine regulated transcripts in the urinary bladder of wild type (WT) and VIP(-/-) mice with or without CYP-induced cystitis (150 mg/kg; i.p.; 48 h). |
| T6 |
800-1032 |
Sentence |
denotes |
Four binary comparisons were made: WT control versus CYP treatment (48 h), VIP(-/-) control versus CYP treatment (48 h), WT control versus VIP(-/-) control, and WT with CYP treatment (48 h) versus VIP(-/-) with CYP treatment (48 h). |
| T6 |
800-1032 |
Sentence |
denotes |
Four binary comparisons were made: WT control versus CYP treatment (48 h), VIP(-/-) control versus CYP treatment (48 h), WT control versus VIP(-/-) control, and WT with CYP treatment (48 h) versus VIP(-/-) with CYP treatment (48 h). |
| T7 |
1033-1184 |
Sentence |
denotes |
The genes presented represent (1) greater than 1.5-fold change in either direction and (2) the p value is less than 0.05 for the comparison being made. |
| T7 |
1033-1184 |
Sentence |
denotes |
The genes presented represent (1) greater than 1.5-fold change in either direction and (2) the p value is less than 0.05 for the comparison being made. |
| T8 |
1185-1286 |
Sentence |
denotes |
Several regulated genes were validated using enzyme-linked immunoassays including IL-1beta and CXCL1. |
| T8 |
1185-1286 |
Sentence |
denotes |
Several regulated genes were validated using enzyme-linked immunoassays including IL-1beta and CXCL1. |
| T9 |
1287-1611 |
Sentence |
denotes |
CYP treatment significantly (p < or = 0.001) increased expression of CXCL1 and IL-1beta in the urinary bladder of WT and VIP(-/-) mice, but expression in VIP(-/-) mice with CYP treatment was significantly (p < or = 0.001) greater (4.2- to 13-fold increase) than that observed in WT urinary bladder (3.6- to 5-fold increase). |
| T9 |
1287-1611 |
Sentence |
denotes |
CYP treatment significantly (p < or = 0.001) increased expression of CXCL1 and IL-1beta in the urinary bladder of WT and VIP(-/-) mice, but expression in VIP(-/-) mice with CYP treatment was significantly (p < or = 0.001) greater (4.2- to 13-fold increase) than that observed in WT urinary bladder (3.6- to 5-fold increase). |
| T10 |
1612-1750 |
Sentence |
denotes |
The data suggest that in VIP(-/-) mice with bladder inflammation, inflammatory mediators are increased above that observed in WT with CYP. |
| T10 |
1612-1750 |
Sentence |
denotes |
The data suggest that in VIP(-/-) mice with bladder inflammation, inflammatory mediators are increased above that observed in WT with CYP. |
| T11 |
1751-1925 |
Sentence |
denotes |
This shift in balance may contribute to increased bladder dysfunction in VIP(-/-) mice with bladder inflammation and altered neurochemical expression in micturition pathways. |
| T11 |
1751-1925 |
Sentence |
denotes |
This shift in balance may contribute to increased bladder dysfunction in VIP(-/-) mice with bladder inflammation and altered neurochemical expression in micturition pathways. |
