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PubMed:18470928 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-82 Sentence denotes IL23R haplotypes provide a large population attributable risk for Crohn's disease.
T1 0-82 Sentence denotes IL23R haplotypes provide a large population attributable risk for Crohn's disease.
T2 83-94 Sentence denotes BACKGROUND:
T2 83-94 Sentence denotes BACKGROUND:
T3 95-225 Sentence denotes The IL-23 pathway plays a pivotal role in the development of chronic mucosal inflammation seen in the inflammatory bowel diseases.
T3 95-225 Sentence denotes The IL-23 pathway plays a pivotal role in the development of chronic mucosal inflammation seen in the inflammatory bowel diseases.
T4 226-410 Sentence denotes Multiple studies have now established the contribution of the interleukin 23 receptor gene (IL23R) to Crohn's disease (CD) risk in general and of the IL23R R381Q variant in particular.
T4 226-410 Sentence denotes Multiple studies have now established the contribution of the interleukin 23 receptor gene (IL23R) to Crohn's disease (CD) risk in general and of the IL23R R381Q variant in particular.
T5 411-527 Sentence denotes The aim of this work was to estimate the total contribution of this gene to CD risk test using a haplotype approach.
T5 411-527 Sentence denotes The aim of this work was to estimate the total contribution of this gene to CD risk test using a haplotype approach.
T6 528-536 Sentence denotes METHODS:
T6 528-536 Sentence denotes METHODS:
T7 537-678 Sentence denotes In all, 763 CD subjects and 254 controls were genotyped for single nucleotide polymorphisms in the IL23R gene using Illumina and ABI methods.
T7 537-678 Sentence denotes In all, 763 CD subjects and 254 controls were genotyped for single nucleotide polymorphisms in the IL23R gene using Illumina and ABI methods.
T8 679-783 Sentence denotes Haplotypes were assigned using PHASEv2 and tested for association with CD by chi-square and permutation.
T8 679-783 Sentence denotes Haplotypes were assigned using PHASEv2 and tested for association with CD by chi-square and permutation.
T9 784-792 Sentence denotes RESULTS:
T9 784-792 Sentence denotes RESULTS:
T10 793-906 Sentence denotes Haplotypes with both increased and decreased risk for CD were observed in 2 of the 4 observed blocks (Block 2 H1:
T10 793-906 Sentence denotes Haplotypes with both increased and decreased risk for CD were observed in 2 of the 4 observed blocks (Block 2 H1:
T11 907-944 Sentence denotes 55.4% control, 64% CD, P = 0.019; H2:
T11 907-944 Sentence denotes 55.4% control, 64% CD, P = 0.019; H2:
T12 945-992 Sentence denotes 64.5% control, 54.4% CD, P = 0.006; Block 3 H1:
T12 945-992 Sentence denotes 64.5% control, 54.4% CD, P = 0.006; Block 3 H1:
T13 993-1032 Sentence denotes 55.8% control, 64.4% CD, P = 0.013; H2:
T13 993-1032 Sentence denotes 55.8% control, 64.4% CD, P = 0.013; H2:
T14 1033-1069 Sentence denotes 47.0% control, 36.6% CD, P = 0.001).
T14 1033-1069 Sentence denotes 47.0% control, 36.6% CD, P = 0.001).
T15 1070-1314 Sentence denotes The population attributable risk for these haplotypes was substantially larger than that estimated for the IL23R R381Q variant (Block 2 H1 and block 3 H1 approximately 20%, compared with approximately 4% for Block 3 H6, containing the variant).
T15 1070-1314 Sentence denotes The population attributable risk for these haplotypes was substantially larger than that estimated for the IL23R R381Q variant (Block 2 H1 and block 3 H1 approximately 20%, compared with approximately 4% for Block 3 H6, containing the variant).
T16 1315-1327 Sentence denotes CONCLUSIONS:
T16 1315-1327 Sentence denotes CONCLUSIONS:
T17 1328-1499 Sentence denotes These observations suggest that IL23R makes a substantial contribution to CD susceptibility, larger than that estimated from the population frequency of the R381Q variant.
T17 1328-1499 Sentence denotes These observations suggest that IL23R makes a substantial contribution to CD susceptibility, larger than that estimated from the population frequency of the R381Q variant.
T18 1500-1792 Sentence denotes These observations also support the expectation that finding "hits" from genomewide association studies will be but an important chapter in the story of unraveling the genetic contribution to CD, rather than the final chapter that brings clarity to all the plot twists of a complicated story.
T18 1500-1792 Sentence denotes These observations also support the expectation that finding "hits" from genomewide association studies will be but an important chapter in the story of unraveling the genetic contribution to CD, rather than the final chapter that brings clarity to all the plot twists of a complicated story.