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PubMed:18332098 JSONTXT 3 Projects

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Id Subject Object Predicate Lexical cue
T1 0-99 Sentence denotes Sequencing-based genotyping and association analysis of the MICA and MICB genes in type 1 diabetes.
T1 0-99 Sentence denotes Sequencing-based genotyping and association analysis of the MICA and MICB genes in type 1 diabetes.
T2 100-110 Sentence denotes OBJECTIVE:
T2 100-110 Sentence denotes OBJECTIVE:
T3 111-252 Sentence denotes The nonclassical major histocompatibility complex (MHC) class I chain-related molecules (MICs), encoded within the MHC, function in immunity.
T3 111-252 Sentence denotes The nonclassical major histocompatibility complex (MHC) class I chain-related molecules (MICs), encoded within the MHC, function in immunity.
T4 253-359 Sentence denotes The transmembrane polymorphism in MICA (MICA-STR) has been reported to be associated with type 1 diabetes.
T4 253-359 Sentence denotes The transmembrane polymorphism in MICA (MICA-STR) has been reported to be associated with type 1 diabetes.
T5 360-609 Sentence denotes In this study, we directly sequenced both of the highly polymorphic MIC genes (MICA and MICB) in order to establish whether they are associated with type 1 diabetes independently of the known type 1 diabetes MHC class II genes HLA-DRB1 and HLA-DQB1.
T5 360-609 Sentence denotes In this study, we directly sequenced both of the highly polymorphic MIC genes (MICA and MICB) in order to establish whether they are associated with type 1 diabetes independently of the known type 1 diabetes MHC class II genes HLA-DRB1 and HLA-DQB1.
T6 610-638 Sentence denotes RESEARCH DESIGN AND METHODS:
T6 610-638 Sentence denotes RESEARCH DESIGN AND METHODS:
T7 639-1014 Sentence denotes We developed a sequencing-based typing method and genotyped MICA and MICB in 818 families (2,944 individuals) with type 1 diabetes from the U.K. and U.S. (constructing the genotype from single nucleotide polymorphisms in exons 2-4 of MICA and 2-5 of MICB) and additionally genotyped the MICA-STR in 2,023 type 1 diabetic case subjects and 1,748 control subjects from the U.K.
T7 639-1014 Sentence denotes We developed a sequencing-based typing method and genotyped MICA and MICB in 818 families (2,944 individuals) with type 1 diabetes from the U.K. and U.S. (constructing the genotype from single nucleotide polymorphisms in exons 2-4 of MICA and 2-5 of MICB) and additionally genotyped the MICA-STR in 2,023 type 1 diabetic case subjects and 1,748 control subjects from the U.K.
T8 1015-1132 Sentence denotes We analyzed the association of the MICA and MICB alleles and genotypes with type 1 diabetes using regression methods.
T8 1015-1132 Sentence denotes We analyzed the association of the MICA and MICB alleles and genotypes with type 1 diabetes using regression methods.
T9 1133-1141 Sentence denotes RESULTS:
T9 1133-1141 Sentence denotes RESULTS:
T10 1142-1221 Sentence denotes We identified known MICA and MICB alleles and discovered four new MICB alleles.
T10 1142-1221 Sentence denotes We identified known MICA and MICB alleles and discovered four new MICB alleles.
T11 1222-1486 Sentence denotes Based on this large-scale and detailed genotype data, we found no evidence for association of MICA and MICB with type 1 diabetes independently of the MHC class II genes (MICA P = 0.08, MICA-STR P = 0.76, MICB P = 0.03, after conditioning on HLA-DRB1 and HLA-DQB1).
T11 1222-1486 Sentence denotes Based on this large-scale and detailed genotype data, we found no evidence for association of MICA and MICB with type 1 diabetes independently of the MHC class II genes (MICA P = 0.08, MICA-STR P = 0.76, MICB P = 0.03, after conditioning on HLA-DRB1 and HLA-DQB1).
T12 1487-1499 Sentence denotes CONCLUSIONS:
T12 1487-1499 Sentence denotes CONCLUSIONS:
T13 1500-1640 Sentence denotes Common MICA and MICB genetic variations including the MICA-STR are not associated, in a primary way, with susceptibility to type 1 diabetes.
T13 1500-1640 Sentence denotes Common MICA and MICB genetic variations including the MICA-STR are not associated, in a primary way, with susceptibility to type 1 diabetes.