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PubMed:18165598 JSONTXT 26 Projects

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Id Subject Object Predicate Lexical cue
T1 0-148 Sentence denotes The differential effects of bupivacaine and lidocaine on prostaglandin E2 release, cyclooxygenase gene expression and pain in a clinical pain model.
T1 0-148 Sentence denotes The differential effects of bupivacaine and lidocaine on prostaglandin E2 release, cyclooxygenase gene expression and pain in a clinical pain model.
T2 149-160 Sentence denotes BACKGROUND:
T2 149-160 Sentence denotes BACKGROUND:
T3 161-291 Sentence denotes In addition to blocking nociceptive input from surgical sites, long-acting local anesthetics might directly modulate inflammation.
T3 161-291 Sentence denotes In addition to blocking nociceptive input from surgical sites, long-acting local anesthetics might directly modulate inflammation.
T4 292-506 Sentence denotes In the present study, we describe the proinflammatory effects of bupivacaine on local prostaglandin E2 (PGE2) production and cyclooxygenase (COX) gene expression that increases postoperative pain in human subjects.
T4 292-506 Sentence denotes In the present study, we describe the proinflammatory effects of bupivacaine on local prostaglandin E2 (PGE2) production and cyclooxygenase (COX) gene expression that increases postoperative pain in human subjects.
T5 507-515 Sentence denotes METHODS:
T5 507-515 Sentence denotes METHODS:
T6 516-740 Sentence denotes Subjects (n = 114) undergoing extraction of impacted third molars received either 2% lidocaine or 0.5% bupivacaine before surgery and either rofecoxib 50 mg or placebo orally 90 min before surgery and for the following 48 h.
T6 516-740 Sentence denotes Subjects (n = 114) undergoing extraction of impacted third molars received either 2% lidocaine or 0.5% bupivacaine before surgery and either rofecoxib 50 mg or placebo orally 90 min before surgery and for the following 48 h.
T7 741-812 Sentence denotes Oral mucosal biopsies were taken before surgery and 48 h after surgery.
T7 741-812 Sentence denotes Oral mucosal biopsies were taken before surgery and 48 h after surgery.
T8 813-933 Sentence denotes After extraction, a microdialysis probe was placed at the surgical site for PGE2 and thromboxane B2 (TXB2) measurements.
T8 813-933 Sentence denotes After extraction, a microdialysis probe was placed at the surgical site for PGE2 and thromboxane B2 (TXB2) measurements.
T9 934-942 Sentence denotes RESULTS:
T9 934-942 Sentence denotes RESULTS:
T10 943-1113 Sentence denotes The bupivacaine/rofecoxib group reported significantly less pain, as assessed by a visual analog scale, compared with the other three treatment groups over the first 4 h.
T10 943-1113 Sentence denotes The bupivacaine/rofecoxib group reported significantly less pain, as assessed by a visual analog scale, compared with the other three treatment groups over the first 4 h.
T11 1114-1295 Sentence denotes However, the bupivacaine/placebo group reported significantly more pain at 24 h and PGE2 levels during the first 4 h were significantly higher than the other three treatment groups.
T11 1114-1295 Sentence denotes However, the bupivacaine/placebo group reported significantly more pain at 24 h and PGE2 levels during the first 4 h were significantly higher than the other three treatment groups.
T12 1296-1417 Sentence denotes Moreover, bupivacaine significantly increased COX-2 gene expression at 48 h as compared with the lidocaine/placebo group.
T12 1296-1417 Sentence denotes Moreover, bupivacaine significantly increased COX-2 gene expression at 48 h as compared with the lidocaine/placebo group.
T13 1418-1584 Sentence denotes Thromboxane levels were not significantly affected by any of the treatments, indicating that the effects seen were attributable to inhibition of COX-2, but not COX-1.
T13 1418-1584 Sentence denotes Thromboxane levels were not significantly affected by any of the treatments, indicating that the effects seen were attributable to inhibition of COX-2, but not COX-1.
T14 1585-1597 Sentence denotes CONCLUSIONS:
T14 1585-1597 Sentence denotes CONCLUSIONS:
T15 1598-1793 Sentence denotes These results suggest that bupivacaine stimulates COX-2 gene expression after tissue injury, which is associated with higher PGE2 production and pain after the local anesthetic effect dissipates.
T15 1598-1793 Sentence denotes These results suggest that bupivacaine stimulates COX-2 gene expression after tissue injury, which is associated with higher PGE2 production and pain after the local anesthetic effect dissipates.