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PubMed:17926108 JSONTXT 8 Projects

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Id Subject Object Predicate Lexical cue
T1 0-100 Sentence denotes Concentration of soluble interleukin-6 receptors in tears of allergic conjunctival disease patients.
T1 0-100 Sentence denotes Concentration of soluble interleukin-6 receptors in tears of allergic conjunctival disease patients.
T2 101-109 Sentence denotes PURPOSE:
T2 101-109 Sentence denotes PURPOSE:
T3 110-294 Sentence denotes To evaluate the significance of soluble interleukin-6 receptor (sIL-6R) in tears as a clinical indicator of disease exacerbation in patients with allergic conjunctivitis disease (ACD).
T3 110-294 Sentence denotes To evaluate the significance of soluble interleukin-6 receptor (sIL-6R) in tears as a clinical indicator of disease exacerbation in patients with allergic conjunctivitis disease (ACD).
T4 295-303 Sentence denotes METHODS:
T4 295-303 Sentence denotes METHODS:
T5 304-587 Sentence denotes The study groups comprised 13 patients (13 eyes) with vernal keratoconjunctivitis (VKC group), 13 patients (13 eyes) with atopic keratoconjunctivitis (AKC group), 11 patients (11 eyes) with giant papillary conjunctivitis (GPC group), and 10 healthy volunteers (10 eyes) as a control.
T5 304-587 Sentence denotes The study groups comprised 13 patients (13 eyes) with vernal keratoconjunctivitis (VKC group), 13 patients (13 eyes) with atopic keratoconjunctivitis (AKC group), 11 patients (11 eyes) with giant papillary conjunctivitis (GPC group), and 10 healthy volunteers (10 eyes) as a control.
T6 588-660 Sentence denotes Tear samples were collected by the Schirmer I method using filter paper.
T6 588-660 Sentence denotes Tear samples were collected by the Schirmer I method using filter paper.
T7 661-786 Sentence denotes Tear samples were eluted and the concentration of sIL-6R in tear samples was determined by enzyme-linked immunosorbent assay.
T7 661-786 Sentence denotes Tear samples were eluted and the concentration of sIL-6R in tear samples was determined by enzyme-linked immunosorbent assay.
T8 787-1123 Sentence denotes Impression cytology using a nitrocellulose membrane was applied to the upper tarsal conjunctiva, and the mRNA of the signal-transducing molecule glycoprotein 130 (gp130) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was extracted from the membrane and analyzed by semiquantitative reverse transcription-polymerase chain reaction.
T8 787-1123 Sentence denotes Impression cytology using a nitrocellulose membrane was applied to the upper tarsal conjunctiva, and the mRNA of the signal-transducing molecule glycoprotein 130 (gp130) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was extracted from the membrane and analyzed by semiquantitative reverse transcription-polymerase chain reaction.
T9 1124-1324 Sentence denotes In the VKC group, the clinical score was graded on the basis of allergic inflammation of the ocular surface, and the correlation between the concentration of sIL-6R and the clinical score was studied.
T9 1124-1324 Sentence denotes In the VKC group, the clinical score was graded on the basis of allergic inflammation of the ocular surface, and the correlation between the concentration of sIL-6R and the clinical score was studied.
T10 1325-1333 Sentence denotes RESULTS:
T10 1325-1333 Sentence denotes RESULTS:
T11 1334-1505 Sentence denotes The concentration of sIL-6R in tears in the VKC, AKC, GPC, and control groups was 5.1 +/- 4.7, 1.2 +/- 1.7, 2.6 +/- 2.8, and 0.5 +/- 4.3 (mean +/- SD) ng/ml, respectively.
T11 1334-1505 Sentence denotes The concentration of sIL-6R in tears in the VKC, AKC, GPC, and control groups was 5.1 +/- 4.7, 1.2 +/- 1.7, 2.6 +/- 2.8, and 0.5 +/- 4.3 (mean +/- SD) ng/ml, respectively.
T12 1506-1663 Sentence denotes The concentrations of sIL-6R in tears in the VKC and GPC groups were significantly higher than those in the control group (P < 0.001 and 0.05, respectively).
T12 1506-1663 Sentence denotes The concentrations of sIL-6R in tears in the VKC and GPC groups were significantly higher than those in the control group (P < 0.001 and 0.05, respectively).
T13 1664-1784 Sentence denotes The AKC group showed no significant change in the concentration of sIL-6R in tears in comparison with the control group.
T13 1664-1784 Sentence denotes The AKC group showed no significant change in the concentration of sIL-6R in tears in comparison with the control group.
T14 1785-1901 Sentence denotes The gp130/GAPDH mRNA ratio was significantly higher in the patients with ACD than in control individuals (P < 0.05).
T14 1785-1901 Sentence denotes The gp130/GAPDH mRNA ratio was significantly higher in the patients with ACD than in control individuals (P < 0.05).
T15 1902-2077 Sentence denotes The concentration of sIL-6R in tears and the clinical score of allergic inflammation of the ocular surface were significantly correlated in the VKC group (r = 0.53, P < 0.01).
T15 1902-2077 Sentence denotes The concentration of sIL-6R in tears and the clinical score of allergic inflammation of the ocular surface were significantly correlated in the VKC group (r = 0.53, P < 0.01).
T16 2078-2090 Sentence denotes CONCLUSIONS:
T16 2078-2090 Sentence denotes CONCLUSIONS:
T17 2091-2287 Sentence denotes We concluded that IL-6/sIL-6R complex trans-signaling via gp130 is an exacerbating factor of ACD, and that the concentration of sIL-6R in tears is a useful clinical biomarker in patients with ACD.
T17 2091-2287 Sentence denotes We concluded that IL-6/sIL-6R complex trans-signaling via gp130 is an exacerbating factor of ACD, and that the concentration of sIL-6R in tears is a useful clinical biomarker in patients with ACD.