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PubMed:17456510 JSONTXT 6 Projects

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Id Subject Object Predicate Lexical cue
T1 0-71 Sentence denotes Reduced mucosal antimicrobial activity in Crohn's disease of the colon.
T1 0-71 Sentence denotes Reduced mucosal antimicrobial activity in Crohn's disease of the colon.
T2 72-83 Sentence denotes OBJECTIVES:
T2 72-83 Sentence denotes OBJECTIVES:
T3 84-283 Sentence denotes In order to maintain the mucosal barrier against luminal microorganisms the intestinal epithelial cells synthesise various broad-spectrum antimicrobial peptides including defensins and cathelicidins.
T3 84-283 Sentence denotes In order to maintain the mucosal barrier against luminal microorganisms the intestinal epithelial cells synthesise various broad-spectrum antimicrobial peptides including defensins and cathelicidins.
T4 284-354 Sentence denotes Recent studies indicate that both may be deficient in Crohn's disease.
T4 284-354 Sentence denotes Recent studies indicate that both may be deficient in Crohn's disease.
T5 355-549 Sentence denotes To elucidate the possible functional consequences of this deficiency antimicrobial activity in colonic mucosa from patients with inflammatory bowel disease and healthy controls was investigated.
T5 355-549 Sentence denotes To elucidate the possible functional consequences of this deficiency antimicrobial activity in colonic mucosa from patients with inflammatory bowel disease and healthy controls was investigated.
T6 550-558 Sentence denotes METHODS:
T6 550-558 Sentence denotes METHODS:
T7 559-1062 Sentence denotes A flow cytometric assay was established to quantitate bacterial killing and test the antibacterial activity of cationic peptide extracts from colonic biopsies taken from patients with active or inactive ileocolonic or colonic Crohn's disease (n = 22), ulcerative colitis (n = 29) and controls (n = 13) against clinical isolates of Bacteroides vulgatus and Enterococcus faecalis or the reference strains Escherichia coli American Type Culture Collection (ATCC) 25922 and Staphylococcus aureus ATCC 25923.
T7 559-1062 Sentence denotes A flow cytometric assay was established to quantitate bacterial killing and test the antibacterial activity of cationic peptide extracts from colonic biopsies taken from patients with active or inactive ileocolonic or colonic Crohn's disease (n = 22), ulcerative colitis (n = 29) and controls (n = 13) against clinical isolates of Bacteroides vulgatus and Enterococcus faecalis or the reference strains Escherichia coli American Type Culture Collection (ATCC) 25922 and Staphylococcus aureus ATCC 25923.
T8 1063-1071 Sentence denotes RESULTS:
T8 1063-1071 Sentence denotes RESULTS:
T9 1072-1229 Sentence denotes Compared with controls and ulcerative colitis there was a reduced antimicrobial effect in Crohn's disease extracts that was most evident against B. vulgatus.
T9 1072-1229 Sentence denotes Compared with controls and ulcerative colitis there was a reduced antimicrobial effect in Crohn's disease extracts that was most evident against B. vulgatus.
T10 1230-1363 Sentence denotes The antimicrobial effect against E. coli and E. faecalis was significantly lower in Crohn's disease compared with ulcerative colitis.
T10 1230-1363 Sentence denotes The antimicrobial effect against E. coli and E. faecalis was significantly lower in Crohn's disease compared with ulcerative colitis.
T11 1364-1444 Sentence denotes Activity against S. aureus disclosed a similar pattern, but was less pronounced.
T11 1364-1444 Sentence denotes Activity against S. aureus disclosed a similar pattern, but was less pronounced.
T12 1445-1537 Sentence denotes The differences were independent of the inflammation status or concurrent steroid treatment.
T12 1445-1537 Sentence denotes The differences were independent of the inflammation status or concurrent steroid treatment.
T13 1538-1819 Sentence denotes Bacteria incubated with biopsy extracts from ulcerative colitis patients frequently showed a characteristic change in cell size and granularity, compatible with more extensive membrane disintegration, compared with bacteria incubated with extracts from controls or Crohn's disease.
T13 1538-1819 Sentence denotes Bacteria incubated with biopsy extracts from ulcerative colitis patients frequently showed a characteristic change in cell size and granularity, compatible with more extensive membrane disintegration, compared with bacteria incubated with extracts from controls or Crohn's disease.
T14 1820-1831 Sentence denotes CONCLUSION:
T14 1820-1831 Sentence denotes CONCLUSION:
T15 1832-2002 Sentence denotes Crohn's disease of the colon is characterized by a diminished functional antimicrobial activity that is consistent with the reported low antibacterial peptide expression.
T15 1832-2002 Sentence denotes Crohn's disease of the colon is characterized by a diminished functional antimicrobial activity that is consistent with the reported low antibacterial peptide expression.