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PubMed:17444670 JSONTXT 28 Projects

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Id Subject Object Predicate Lexical cue
T1 0-92 Sentence denotes Retinal Mueller glial cells trigger the hallmark inflammatory process in autoimmune uveitis.
T1 0-92 Sentence denotes Retinal Mueller glial cells trigger the hallmark inflammatory process in autoimmune uveitis.
T2 93-189 Sentence denotes Spontaneous equine recurrent uveitis (ERU) is an incurable autoimmune disease affecting the eye.
T2 93-189 Sentence denotes Spontaneous equine recurrent uveitis (ERU) is an incurable autoimmune disease affecting the eye.
T3 190-409 Sentence denotes Although retinal-autoantigen specific T-helper 1 cells have been demonstrated to trigger disease progression and relapses, the molecular processes leading to retinal degeneration and consequent blindness remain unknown.
T3 190-409 Sentence denotes Although retinal-autoantigen specific T-helper 1 cells have been demonstrated to trigger disease progression and relapses, the molecular processes leading to retinal degeneration and consequent blindness remain unknown.
T4 410-540 Sentence denotes To elucidate such processes, we studied changes in the total retinal proteome of ERU-diseased horses compared to healthy controls.
T4 410-540 Sentence denotes To elucidate such processes, we studied changes in the total retinal proteome of ERU-diseased horses compared to healthy controls.
T5 541-698 Sentence denotes Severe changes in the retinal proteome were found for several markers for blood-retinal barrier breakdown and whose emergence depended upon disease severity.
T5 541-698 Sentence denotes Severe changes in the retinal proteome were found for several markers for blood-retinal barrier breakdown and whose emergence depended upon disease severity.
T6 699-1022 Sentence denotes Additionally, uveitic changes in the retina were accompanied by upregulation of aldose 1-epimerase, selenium-binding protein 1, alpha crystallin A chain, phosphatase 2A inhibitor (SET), and glial fibrillary acidic protein (GFAP), the latter indicating an involvement of retinal Mueller glial cells (RMG) in disease process.
T6 699-1022 Sentence denotes Additionally, uveitic changes in the retina were accompanied by upregulation of aldose 1-epimerase, selenium-binding protein 1, alpha crystallin A chain, phosphatase 2A inhibitor (SET), and glial fibrillary acidic protein (GFAP), the latter indicating an involvement of retinal Mueller glial cells (RMG) in disease process.
T7 1023-1221 Sentence denotes To confirm this, we screened for additional RMG-specific markers and could demonstrate that, in uveitic retinas, RMG concomitantly upregulate vimentin and GFAP and downregulate glutamine synthetase.
T7 1023-1221 Sentence denotes To confirm this, we screened for additional RMG-specific markers and could demonstrate that, in uveitic retinas, RMG concomitantly upregulate vimentin and GFAP and downregulate glutamine synthetase.
T8 1222-1469 Sentence denotes These expression patterns suggest for an activated state of RMG, which further downregulate the expression of pigment epithelium-derived factor (PEDF) and begin expressing interferon-gamma, a pro-inflammatory cytokine typical for T-helper 1 cells.
T8 1222-1469 Sentence denotes These expression patterns suggest for an activated state of RMG, which further downregulate the expression of pigment epithelium-derived factor (PEDF) and begin expressing interferon-gamma, a pro-inflammatory cytokine typical for T-helper 1 cells.
T9 1470-1651 Sentence denotes We thus propose that RMG may play a fatal role in uveitic disease progression by directly triggering inflammatory processes through the expression and secretion of interferon-gamma.
T9 1470-1651 Sentence denotes We thus propose that RMG may play a fatal role in uveitic disease progression by directly triggering inflammatory processes through the expression and secretion of interferon-gamma.