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PubMed:17403684 JSONTXT 23 Projects

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Id Subject Object Predicate Lexical cue
T1 0-119 Sentence denotes Post-translational methylation of high mobility group box 1 (HMGB1) causes its cytoplasmic localization in neutrophils.
T1 0-119 Sentence denotes Post-translational methylation of high mobility group box 1 (HMGB1) causes its cytoplasmic localization in neutrophils.
T2 120-243 Sentence denotes High mobility group box 1 (HMGB1) protein plays multiple roles in transcription, replication, and cellular differentiation.
T2 120-243 Sentence denotes High mobility group box 1 (HMGB1) protein plays multiple roles in transcription, replication, and cellular differentiation.
T3 244-384 Sentence denotes HMGB1 is also secreted by activated monocytes and macrophages and passively released by necrotic or damaged cells, stimulating inflammation.
T3 244-384 Sentence denotes HMGB1 is also secreted by activated monocytes and macrophages and passively released by necrotic or damaged cells, stimulating inflammation.
T4 385-621 Sentence denotes HMGB1 is a novel antigen of anti-neutrophil cytoplasmic antibodies (ANCA) observed in the sera of patients with ulcerative colitis and autoimmune hepatitis, suggesting that HMGB1 is secreted from neutrophils to the extracellular milieu.
T4 385-621 Sentence denotes HMGB1 is a novel antigen of anti-neutrophil cytoplasmic antibodies (ANCA) observed in the sera of patients with ulcerative colitis and autoimmune hepatitis, suggesting that HMGB1 is secreted from neutrophils to the extracellular milieu.
T5 622-746 Sentence denotes However, the actual distribution of HMGB1 in the cytoplasm of neutrophils and the mechanisms responsible for it are obscure.
T5 622-746 Sentence denotes However, the actual distribution of HMGB1 in the cytoplasm of neutrophils and the mechanisms responsible for it are obscure.
T6 747-835 Sentence denotes Here we show that HMGB1 in neutrophils is post-translationally mono-methylated at Lys42.
T6 747-835 Sentence denotes Here we show that HMGB1 in neutrophils is post-translationally mono-methylated at Lys42.
T7 836-1021 Sentence denotes The methylation alters the conformation of HMGB1 and weakens its DNA binding activity, causing it to become largely distributed in the cytoplasm by passive diffusion out of the nucleus.
T7 836-1021 Sentence denotes The methylation alters the conformation of HMGB1 and weakens its DNA binding activity, causing it to become largely distributed in the cytoplasm by passive diffusion out of the nucleus.
T8 1022-1119 Sentence denotes Thus, post-translational methylation of HMGB1 causes its cytoplasmic localization in neutrophils.
T8 1022-1119 Sentence denotes Thus, post-translational methylation of HMGB1 causes its cytoplasmic localization in neutrophils.
T9 1120-1292 Sentence denotes This novel pathway explains the distribution of nuclear HMGB1 to the cytoplasm and is important for understanding how neutrophils release HMGB1 to the extracellular milieu.
T9 1120-1292 Sentence denotes This novel pathway explains the distribution of nuclear HMGB1 to the cytoplasm and is important for understanding how neutrophils release HMGB1 to the extracellular milieu.