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PubMed:17372179 JSONTXT 6 Projects

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Id Subject Object Predicate Lexical cue
T1 0-92 Sentence denotes Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke.
T1 0-92 Sentence denotes Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke.
T2 93-104 Sentence denotes BACKGROUND:
T2 93-104 Sentence denotes BACKGROUND:
T3 105-158 Sentence denotes Stroke is the second to third leading cause of death.
T3 105-158 Sentence denotes Stroke is the second to third leading cause of death.
T4 159-322 Sentence denotes Toll-like receptor 4 (TLR4) is a signaling receptor in innate immunity that is a specific immunologic response to systemic bacterial infection and cerebral injury.
T4 159-322 Sentence denotes Toll-like receptor 4 (TLR4) is a signaling receptor in innate immunity that is a specific immunologic response to systemic bacterial infection and cerebral injury.
T5 323-384 Sentence denotes The role of TLR4 in brain ischemia has not been examined yet.
T5 323-384 Sentence denotes The role of TLR4 in brain ischemia has not been examined yet.
T6 385-582 Sentence denotes We have therefore investigated whether cerebral ischemia and inflammation produced by permanent occlusion of the middle cerebral artery differ in mice that lack a functional TLR4 signaling pathway.
T6 385-582 Sentence denotes We have therefore investigated whether cerebral ischemia and inflammation produced by permanent occlusion of the middle cerebral artery differ in mice that lack a functional TLR4 signaling pathway.
T7 583-603 Sentence denotes METHODS AND RESULTS:
T7 583-603 Sentence denotes METHODS AND RESULTS:
T8 604-782 Sentence denotes Permanent occlusion of the middle cerebral artery was performed on 2 strains of TLR4-deficient mice (C3H/HeJ and C57BL/10ScNJ) and respective controls (C3H/HeN and C57BL/10ScSn).
T8 604-782 Sentence denotes Permanent occlusion of the middle cerebral artery was performed on 2 strains of TLR4-deficient mice (C3H/HeJ and C57BL/10ScNJ) and respective controls (C3H/HeN and C57BL/10ScSn).
T9 783-885 Sentence denotes Stroke outcome was evaluated by determination of infarct volume and assessment of neurological scores.
T9 783-885 Sentence denotes Stroke outcome was evaluated by determination of infarct volume and assessment of neurological scores.
T10 886-941 Sentence denotes Brains were collected 24 hours and 7 days after stroke.
T10 886-941 Sentence denotes Brains were collected 24 hours and 7 days after stroke.
T11 942-1078 Sentence denotes When compared with control mice, TLR4-deficient mice had lower infarct volumes and better outcomes in neurological and behavioral tests.
T11 942-1078 Sentence denotes When compared with control mice, TLR4-deficient mice had lower infarct volumes and better outcomes in neurological and behavioral tests.
T12 1079-1264 Sentence denotes Mice that lacked TLR4 had minor expression of stroke-induced interferon regulatory factor-1, inducible nitric oxide synthase, and cyclooxygenase-2, mediators implicated in brain damage.
T12 1079-1264 Sentence denotes Mice that lacked TLR4 had minor expression of stroke-induced interferon regulatory factor-1, inducible nitric oxide synthase, and cyclooxygenase-2, mediators implicated in brain damage.
T13 1265-1431 Sentence denotes The levels of interferon-beta and of the lipid peroxidation marker malondialdehyde were also lower in brains from TLR4-deficient mice than in those from control mice.
T13 1265-1431 Sentence denotes The levels of interferon-beta and of the lipid peroxidation marker malondialdehyde were also lower in brains from TLR4-deficient mice than in those from control mice.
T14 1432-1601 Sentence denotes In addition, the expression of matrix metalloproteinase-9, which is induced and mediates brain damage, was also reduced in TLR4-deficient mice after experimental stroke.
T14 1432-1601 Sentence denotes In addition, the expression of matrix metalloproteinase-9, which is induced and mediates brain damage, was also reduced in TLR4-deficient mice after experimental stroke.
T15 1602-1714 Sentence denotes CONCLUSIONS: TLR4-deficient mice have minor infarctions and less inflammatory response after an ischemic insult.
T15 1602-1714 Sentence denotes CONCLUSIONS: TLR4-deficient mice have minor infarctions and less inflammatory response after an ischemic insult.
T16 1715-1856 Sentence denotes These data demonstrate that TLR4 signaling and innate immunity are involved in brain damage and in inflammation triggered by ischemic injury.
T16 1715-1856 Sentence denotes These data demonstrate that TLR4 signaling and innate immunity are involved in brain damage and in inflammation triggered by ischemic injury.