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PubMed:17277312 JSONTXT 25 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-76 Sentence denotes STAT3 regulates cytokine-mediated generation of inflammatory helper T cells.
T1 0-76 Sentence denotes STAT3 regulates cytokine-mediated generation of inflammatory helper T cells.
T2 77-241 Sentence denotes Interleukin-17 (IL-17)-producing helper T (TH) cells, named as TH(IL-17), TH17, or inflammatory TH (THi), have been recently identified as a novel effector lineage.
T2 77-241 Sentence denotes Interleukin-17 (IL-17)-producing helper T (TH) cells, named as TH(IL-17), TH17, or inflammatory TH (THi), have been recently identified as a novel effector lineage.
T3 242-311 Sentence denotes However, how cytokine signals mediate THi differentiation is unclear.
T3 242-311 Sentence denotes However, how cytokine signals mediate THi differentiation is unclear.
T4 312-428 Sentence denotes We found that IL-6 functioned to up-regulate IL-23R and that IL-23 synergized with IL-6 in promoting THi generation.
T4 312-428 Sentence denotes We found that IL-6 functioned to up-regulate IL-23R and that IL-23 synergized with IL-6 in promoting THi generation.
T5 429-511 Sentence denotes STAT3, activated by both IL-6 and IL-23, plays a critical role in THi development.
T5 429-511 Sentence denotes STAT3, activated by both IL-6 and IL-23, plays a critical role in THi development.
T6 512-651 Sentence denotes A hyperactive form of STAT3 promoted THi development, whereas this differentiation process was greatly impaired in STAT3-deficient T cells.
T6 512-651 Sentence denotes A hyperactive form of STAT3 promoted THi development, whereas this differentiation process was greatly impaired in STAT3-deficient T cells.
T7 652-952 Sentence denotes Moreover, STAT3 regulated the expression of retinoic acid receptor-related orphan receptor gamma-T (RORgamma t), a THi-specific transcriptional regulator; STAT3 deficiency impaired RORgamma t expression and led to elevated expression of T-box expressed in T cells (T-bet) and Forkhead box P3 (Foxp3).
T7 652-952 Sentence denotes Moreover, STAT3 regulated the expression of retinoic acid receptor-related orphan receptor gamma-T (RORgamma t), a THi-specific transcriptional regulator; STAT3 deficiency impaired RORgamma t expression and led to elevated expression of T-box expressed in T cells (T-bet) and Forkhead box P3 (Foxp3).
T8 953-1142 Sentence denotes Our data thus demonstrate a pathway whereby cytokines regulate THi differentiation through a selective STAT transcription factor that functions to regulate lineage-specific gene expression.
T8 953-1142 Sentence denotes Our data thus demonstrate a pathway whereby cytokines regulate THi differentiation through a selective STAT transcription factor that functions to regulate lineage-specific gene expression.