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PubMed:16624562 JSONTXT 8 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-105 Sentence denotes Blood-brain barrier disruption by stromelysin-1 facilitates neutrophil infiltration in neuroinflammation.
T1 0-105 Sentence denotes Blood-brain barrier disruption by stromelysin-1 facilitates neutrophil infiltration in neuroinflammation.
T2 106-209 Sentence denotes Blood-brain barrier (BBB) opening is mediated by matrix metalloproteinases (MMPs) in neuroinflammation.
T2 106-209 Sentence denotes Blood-brain barrier (BBB) opening is mediated by matrix metalloproteinases (MMPs) in neuroinflammation.
T3 210-361 Sentence denotes We tested the hypothesis that MMP-3 plays a role in BBB damage, using MMP-3 knockout (KO) mice and lipopolysaccharide (LPS)-induced opening of the BBB.
T3 210-361 Sentence denotes We tested the hypothesis that MMP-3 plays a role in BBB damage, using MMP-3 knockout (KO) mice and lipopolysaccharide (LPS)-induced opening of the BBB.
T4 362-478 Sentence denotes We found less disruption of the BBB after intracerebral LPS injection in MMP-3 KO mice than in wild type (P<0.0006).
T4 362-478 Sentence denotes We found less disruption of the BBB after intracerebral LPS injection in MMP-3 KO mice than in wild type (P<0.0006).
T5 479-554 Sentence denotes MMP-3 KO mice had less MMP-9 than WT mice but similar levels of activation.
T5 479-554 Sentence denotes MMP-3 KO mice had less MMP-9 than WT mice but similar levels of activation.
T6 555-695 Sentence denotes Moreover, MMP-9 mRNA levels were increased to a similar level in both the MMP-3 KO and WT, suggesting both endogenous and exogenous sources.
T6 555-695 Sentence denotes Moreover, MMP-9 mRNA levels were increased to a similar level in both the MMP-3 KO and WT, suggesting both endogenous and exogenous sources.
T7 696-797 Sentence denotes Unbiased stereology showed increased neutrophil counts in the brains of MMP-3 WT compared to KO mice.
T7 696-797 Sentence denotes Unbiased stereology showed increased neutrophil counts in the brains of MMP-3 WT compared to KO mice.
T8 798-951 Sentence denotes Degradation of tight junction proteins, claudin-5 and occludin, and the basal lamina protein, laminin-alpha1, was less affected in the KO than in the WT.
T8 798-951 Sentence denotes Degradation of tight junction proteins, claudin-5 and occludin, and the basal lamina protein, laminin-alpha1, was less affected in the KO than in the WT.
T9 952-1120 Sentence denotes Our results provide the first in vivo evidence that MMP-3 attacks the basal lamina and tight junction proteins, opening the BBB, thereby facilitating neutrophil influx.
T9 952-1120 Sentence denotes Our results provide the first in vivo evidence that MMP-3 attacks the basal lamina and tight junction proteins, opening the BBB, thereby facilitating neutrophil influx.