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PubMed:16601286 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-185 Sentence denotes Increased expression of type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) and its relationship with androgen receptor in prostate carcinoma.
T1 0-185 Sentence denotes Increased expression of type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) and its relationship with androgen receptor in prostate carcinoma.
T2 186-434 Sentence denotes Type 2 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD) is a multi-functional enzyme that possesses 3alpha-, 17beta- and 20alpha-HSD, as well as prostaglandin (PG) F synthase activities and catalyzes androgen, estrogen, progestin and PG metabolism.
T2 186-434 Sentence denotes Type 2 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD) is a multi-functional enzyme that possesses 3alpha-, 17beta- and 20alpha-HSD, as well as prostaglandin (PG) F synthase activities and catalyzes androgen, estrogen, progestin and PG metabolism.
T3 435-563 Sentence denotes Type 2 3alpha-HSD was cloned from human prostate, is a member of the aldo-keto reductase (AKR) superfamily and was named AKR1C3.
T3 435-563 Sentence denotes Type 2 3alpha-HSD was cloned from human prostate, is a member of the aldo-keto reductase (AKR) superfamily and was named AKR1C3.
T4 564-810 Sentence denotes In androgen target tissues such as the prostate, AKR1C3 catalyzes the conversion of Delta(4)-androstene-3,17-dione to testosterone, 5alpha-dihydrotestosterone to 5alpha-androstane-3alpha,17beta-diol (3alpha-diol), and 3alpha-diol to androsterone.
T4 564-810 Sentence denotes In androgen target tissues such as the prostate, AKR1C3 catalyzes the conversion of Delta(4)-androstene-3,17-dione to testosterone, 5alpha-dihydrotestosterone to 5alpha-androstane-3alpha,17beta-diol (3alpha-diol), and 3alpha-diol to androsterone.
T5 811-930 Sentence denotes Thus AKR1C3 may regulate the balance of androgens and hence trans-activation of the androgen receptor in these tissues.
T5 811-930 Sentence denotes Thus AKR1C3 may regulate the balance of androgens and hence trans-activation of the androgen receptor in these tissues.
T6 931-1031 Sentence denotes Tissue distribution studies indicate that AKR1C3 transcripts are highly expressed in human prostate.
T6 931-1031 Sentence denotes Tissue distribution studies indicate that AKR1C3 transcripts are highly expressed in human prostate.
T7 1032-1171 Sentence denotes To measure AKR1C3 protein expression and its distribution in the prostate, we raised a monoclonal antibody specifically recognizing AKR1C3.
T7 1032-1171 Sentence denotes To measure AKR1C3 protein expression and its distribution in the prostate, we raised a monoclonal antibody specifically recognizing AKR1C3.
T8 1172-1268 Sentence denotes This antibody allowed us to distinguish AKR1C3 from other AKR1C family members in human tissues.
T8 1172-1268 Sentence denotes This antibody allowed us to distinguish AKR1C3 from other AKR1C family members in human tissues.
T9 1269-1442 Sentence denotes Immunoblot analysis showed that this monoclonal antibody binds to one species of protein in primary cultures of prostate epithelial cells and in LNCaP prostate cancer cells.
T9 1269-1442 Sentence denotes Immunoblot analysis showed that this monoclonal antibody binds to one species of protein in primary cultures of prostate epithelial cells and in LNCaP prostate cancer cells.
T10 1443-1659 Sentence denotes Immunohistochemistry with this antibody on human prostate detected strong nuclear immunoreactivity in normal stromal and smooth muscle cells, perineurial cells, urothelial (transitional) cells, and endothelial cells.
T10 1443-1659 Sentence denotes Immunohistochemistry with this antibody on human prostate detected strong nuclear immunoreactivity in normal stromal and smooth muscle cells, perineurial cells, urothelial (transitional) cells, and endothelial cells.
T11 1660-1738 Sentence denotes Normal prostate epithelial cells were only faintly immunoreactive or negative.
T11 1660-1738 Sentence denotes Normal prostate epithelial cells were only faintly immunoreactive or negative.
T12 1739-1835 Sentence denotes Positive immunoreactivity was demonstrated in primary prostatic adenocarcinoma in 9 of 11 cases.
T12 1739-1835 Sentence denotes Positive immunoreactivity was demonstrated in primary prostatic adenocarcinoma in 9 of 11 cases.
T13 1836-2036 Sentence denotes Variable increases in immunoreactivity for AKR1C3 was also demonstrated in non-neoplastic changes in the prostate including chronic inflammation, atrophy and urothelial (transitional) cell metaplasia.
T13 1836-2036 Sentence denotes Variable increases in immunoreactivity for AKR1C3 was also demonstrated in non-neoplastic changes in the prostate including chronic inflammation, atrophy and urothelial (transitional) cell metaplasia.
T14 2037-2129 Sentence denotes We conclude that elevated expression of AKR1C3 is highly associated with prostate carcinoma.
T14 2037-2129 Sentence denotes We conclude that elevated expression of AKR1C3 is highly associated with prostate carcinoma.
T15 2130-2327 Sentence denotes Although the biological significance of elevated AKR1C3 in prostatic carcinoma is uncertain, AKR1C3 may be responsible for the trophic effects of androgens and/or PGs on prostatic epithelial cells.
T15 2130-2327 Sentence denotes Although the biological significance of elevated AKR1C3 in prostatic carcinoma is uncertain, AKR1C3 may be responsible for the trophic effects of androgens and/or PGs on prostatic epithelial cells.