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PubMed:16472595 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-128 Sentence denotes Chitinase 3-like-1 exacerbates intestinal inflammation by enhancing bacterial adhesion and invasion in colonic epithelial cells.
T1 0-128 Sentence denotes Chitinase 3-like-1 exacerbates intestinal inflammation by enhancing bacterial adhesion and invasion in colonic epithelial cells.
T2 129-147 Sentence denotes BACKGROUND & AIMS:
T2 129-147 Sentence denotes BACKGROUND & AIMS:
T3 148-274 Sentence denotes Dysregulated host/microbial interactions appear to play a central role in the development of inflammatory bowel disease (IBD).
T3 148-274 Sentence denotes Dysregulated host/microbial interactions appear to play a central role in the development of inflammatory bowel disease (IBD).
T4 275-362 Sentence denotes However, molecular events leading to the dysregulation have not yet been defined fully.
T4 275-362 Sentence denotes However, molecular events leading to the dysregulation have not yet been defined fully.
T5 363-454 Sentence denotes Studies were designed to characterize a key molecule that is involved in the dysregulation.
T5 363-454 Sentence denotes Studies were designed to characterize a key molecule that is involved in the dysregulation.
T6 455-463 Sentence denotes METHODS:
T6 455-463 Sentence denotes METHODS:
T7 464-620 Sentence denotes Colonic mucosal RNA from C57BL/6 mice on days 4 and 8 with administration of 4% dextran sulfate sodium for 5 days were subjected to DNA microarray analysis.
T7 464-620 Sentence denotes Colonic mucosal RNA from C57BL/6 mice on days 4 and 8 with administration of 4% dextran sulfate sodium for 5 days were subjected to DNA microarray analysis.
T8 621-777 Sentence denotes Chitinase 3-like-1 (CHI3L1) messenger RNA and protein expressions were examined by reverse-transcription polymerase chain reaction and immunohistochemistry.
T8 621-777 Sentence denotes Chitinase 3-like-1 (CHI3L1) messenger RNA and protein expressions were examined by reverse-transcription polymerase chain reaction and immunohistochemistry.
T9 778-944 Sentence denotes A gentamicin protection assay of Salmonella typhimurium was performed using epithelial cell lines that are engineered genetically to overexpress or lack mouse CHI3L1.
T9 778-944 Sentence denotes A gentamicin protection assay of Salmonella typhimurium was performed using epithelial cell lines that are engineered genetically to overexpress or lack mouse CHI3L1.
T10 945-1079 Sentence denotes To examine the functional role of CHI3L1 in vivo, anti-CHI3L1 antibody was administered into the dextran sulfate sodium colitis model.
T10 945-1079 Sentence denotes To examine the functional role of CHI3L1 in vivo, anti-CHI3L1 antibody was administered into the dextran sulfate sodium colitis model.
T11 1080-1088 Sentence denotes RESULTS:
T11 1080-1088 Sentence denotes RESULTS:
T12 1089-1180 Sentence denotes Microarray analysis identified that CHI3L1 is up-regulated specifically in inflamed mucosa.
T12 1089-1180 Sentence denotes Microarray analysis identified that CHI3L1 is up-regulated specifically in inflamed mucosa.
T13 1181-1406 Sentence denotes The expression of CHI3L1 protein clearly was detectable in lamina propria and colonic epithelial cells (CECs) in several murine colitis models and ulcerative colitis and Crohn's disease patients but absent in normal controls.
T13 1181-1406 Sentence denotes The expression of CHI3L1 protein clearly was detectable in lamina propria and colonic epithelial cells (CECs) in several murine colitis models and ulcerative colitis and Crohn's disease patients but absent in normal controls.
T14 1407-1577 Sentence denotes The gentamicin protection assays using intracellular bacteria showed that CHI3L1 is required for the enhancement of adhesion and internalization of these bacteria in CEC.
T14 1407-1577 Sentence denotes The gentamicin protection assays using intracellular bacteria showed that CHI3L1 is required for the enhancement of adhesion and internalization of these bacteria in CEC.
T15 1578-1750 Sentence denotes In vivo neutralization experiments showed that CHI3L1 contributes to the facilitation of bacterial invasion into the intestinal mucosa and the development of acute colitis.
T15 1578-1750 Sentence denotes In vivo neutralization experiments showed that CHI3L1 contributes to the facilitation of bacterial invasion into the intestinal mucosa and the development of acute colitis.
T16 1751-1881 Sentence denotes CONCLUSIONS: CHI3L1 plays a pathogenic role in colitis, presumably by enhancing the adhesion and invasion of bacteria on/into CEC.
T16 1751-1881 Sentence denotes CONCLUSIONS: CHI3L1 plays a pathogenic role in colitis, presumably by enhancing the adhesion and invasion of bacteria on/into CEC.
T17 1882-1958 Sentence denotes Inhibition of CHI3L1 activity would be a novel therapeutic approach for IBD.
T17 1882-1958 Sentence denotes Inhibition of CHI3L1 activity would be a novel therapeutic approach for IBD.