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PubMed:16445950 JSONTXT 3 Projects

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Id Subject Object Predicate Lexical cue
T1 0-100 Sentence denotes The acetylcholinesterase inhibitor, Donepezil, regulates a Th2 bias in Alzheimer's disease patients.
T1 0-100 Sentence denotes The acetylcholinesterase inhibitor, Donepezil, regulates a Th2 bias in Alzheimer's disease patients.
T2 101-204 Sentence denotes The increased pro-inflammatory cytokine production was previously observed in Alzheimer's disease (AD).
T2 101-204 Sentence denotes The increased pro-inflammatory cytokine production was previously observed in Alzheimer's disease (AD).
T3 205-357 Sentence denotes We sought to explore whether acetylcholinesterase inhibitor (AChEI) therapy ameliorates clinical symptoms in AD through down-regulation of inflammation.
T3 205-357 Sentence denotes We sought to explore whether acetylcholinesterase inhibitor (AChEI) therapy ameliorates clinical symptoms in AD through down-regulation of inflammation.
T4 358-604 Sentence denotes Expression and release of monocyte chemotactic protein-1 (MCP-1), a positive regulator of Th2 differentiation, and interleukin (IL)-4, an anti-inflammatory cytokine from peripheral blood mononuclear cells (PBMC) in AD patients, were investigated.
T4 358-604 Sentence denotes Expression and release of monocyte chemotactic protein-1 (MCP-1), a positive regulator of Th2 differentiation, and interleukin (IL)-4, an anti-inflammatory cytokine from peripheral blood mononuclear cells (PBMC) in AD patients, were investigated.
T5 605-746 Sentence denotes PBMC were purified from AD patients at time of enrollment (T0) and after 1 month of treatment with AChEI (T1) and from healthy controls (HC).
T5 605-746 Sentence denotes PBMC were purified from AD patients at time of enrollment (T0) and after 1 month of treatment with AChEI (T1) and from healthy controls (HC).
T6 747-854 Sentence denotes Supernatants were analyzed for cytokine levels by ELISA methods. mRNA expression were determined by RT-PCR.
T6 747-854 Sentence denotes Supernatants were analyzed for cytokine levels by ELISA methods. mRNA expression were determined by RT-PCR.
T7 855-1050 Sentence denotes Expression and production of MCP-1 and IL-4 were significantly increased in AD subjects under therapy with the AChEI Donepezil, compared to the same AD patients at time of enrollment (P < 0.001).
T7 855-1050 Sentence denotes Expression and production of MCP-1 and IL-4 were significantly increased in AD subjects under therapy with the AChEI Donepezil, compared to the same AD patients at time of enrollment (P < 0.001).
T8 1051-1377 Sentence denotes Our data suggest another possible explanation for the ability of Donepezil [diethyl(3,5-di-ter-butyl-4-hydroxybenzyl)phosphonate] to delay the progression of AD; in fact, Donepezil may modulate MCP-1 and IL-4 production, which may reflect a general shift towards type Th0/Th2 cytokines which could be protective in AD disease.
T8 1051-1377 Sentence denotes Our data suggest another possible explanation for the ability of Donepezil [diethyl(3,5-di-ter-butyl-4-hydroxybenzyl)phosphonate] to delay the progression of AD; in fact, Donepezil may modulate MCP-1 and IL-4 production, which may reflect a general shift towards type Th0/Th2 cytokines which could be protective in AD disease.
T9 1378-1593 Sentence denotes The different amounts of MCP-1 and IL-4 observed might reflect the different states of activation and/or responsiveness of PBMC, that in AD patients could be kept in an activated state by pro-inflammatory cytokines.
T9 1378-1593 Sentence denotes The different amounts of MCP-1 and IL-4 observed might reflect the different states of activation and/or responsiveness of PBMC, that in AD patients could be kept in an activated state by pro-inflammatory cytokines.