| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-91 |
Sentence |
denotes |
Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation. |
| T1 |
0-91 |
Sentence |
denotes |
Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation. |
| T2 |
92-235 |
Sentence |
denotes |
Nuclear factor-kappaB (NF-kappaB) is a transcription factor that has crucial roles in inflammation, immunity, cell proliferation and apoptosis. |
| T2 |
92-235 |
Sentence |
denotes |
Nuclear factor-kappaB (NF-kappaB) is a transcription factor that has crucial roles in inflammation, immunity, cell proliferation and apoptosis. |
| T3 |
236-372 |
Sentence |
denotes |
Activation of NF-kappaB mainly occurs via IkappaB kinase (IKK)-mediated phosphorylation of inhibitory molecules, including IkappaBalpha. |
| T3 |
236-372 |
Sentence |
denotes |
Activation of NF-kappaB mainly occurs via IkappaB kinase (IKK)-mediated phosphorylation of inhibitory molecules, including IkappaBalpha. |
| T4 |
373-575 |
Sentence |
denotes |
Optimal induction of NF-kappaB target genes also requires phosphorylation of NF-kappaB proteins, such as p65, within their transactivation domain by a variety of kinases in response to distinct stimuli. |
| T4 |
373-575 |
Sentence |
denotes |
Optimal induction of NF-kappaB target genes also requires phosphorylation of NF-kappaB proteins, such as p65, within their transactivation domain by a variety of kinases in response to distinct stimuli. |
| T5 |
576-717 |
Sentence |
denotes |
Whether, and how, phosphorylation modulates the function of other NF-kappaB and IkappaB proteins, such as B-cell lymphoma 3, remains unclear. |
| T5 |
576-717 |
Sentence |
denotes |
Whether, and how, phosphorylation modulates the function of other NF-kappaB and IkappaB proteins, such as B-cell lymphoma 3, remains unclear. |
| T6 |
718-850 |
Sentence |
denotes |
The identification and characterization of all the kinases known to phosphorylate NF-kappaB and IkappaB proteins are described here. |
| T6 |
718-850 |
Sentence |
denotes |
The identification and characterization of all the kinases known to phosphorylate NF-kappaB and IkappaB proteins are described here. |
| T7 |
851-1093 |
Sentence |
denotes |
Because deregulation of NF-kappaB and IkappaB phosphorylations is a hallmark of chronic inflammatory diseases and cancer, newly designed drugs targeting these constitutively activated signalling pathways represent promising therapeutic tools. |
| T7 |
851-1093 |
Sentence |
denotes |
Because deregulation of NF-kappaB and IkappaB phosphorylations is a hallmark of chronic inflammatory diseases and cancer, newly designed drugs targeting these constitutively activated signalling pathways represent promising therapeutic tools. |