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PubMed:15194535 JSONTXT 4 Projects

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Id Subject Object Predicate Lexical cue
T1 0-109 Sentence denotes Real-time polymerase chain reaction determination of cytokine mRNA expression profiles in Hodgkin's lymphoma.
T1 0-109 Sentence denotes Real-time polymerase chain reaction determination of cytokine mRNA expression profiles in Hodgkin's lymphoma.
T2 110-136 Sentence denotes BACKGROUND AND OBJECTIVES:
T2 110-136 Sentence denotes BACKGROUND AND OBJECTIVES:
T3 137-265 Sentence denotes Classical Hodgkin's lymphoma (HL) is a malignant disorder characterized by a small number of tumor cells and inflammatory cells.
T3 137-265 Sentence denotes Classical Hodgkin's lymphoma (HL) is a malignant disorder characterized by a small number of tumor cells and inflammatory cells.
T4 266-397 Sentence denotes Both the tumor cells and the inflammatory cells produce cytokines which are thought to contribute to the clinical parameters of HL.
T4 266-397 Sentence denotes Both the tumor cells and the inflammatory cells produce cytokines which are thought to contribute to the clinical parameters of HL.
T5 398-479 Sentence denotes Quantification of these cytokines at a protein level is still somewhat imprecise.
T5 398-479 Sentence denotes Quantification of these cytokines at a protein level is still somewhat imprecise.
T6 480-587 Sentence denotes We, therefore, used a method to quantify cytokine mRNA expression in HL cell lines and lymph node biopsies.
T6 480-587 Sentence denotes We, therefore, used a method to quantify cytokine mRNA expression in HL cell lines and lymph node biopsies.
T7 588-607 Sentence denotes DESIGN AND METHODS:
T7 588-607 Sentence denotes DESIGN AND METHODS:
T8 608-985 Sentence denotes We used real-time quantitative polymerase chain reaction (RQ-PCR) to investigate mRNA expression for interleukin (IL)-1alpha, IL-1beta, IL-2, IL-4, IL-5, IL-8, IL-12p35, IL-12p40, IL-13, IL-15, interferon (IFN)-gamma and tumor necrosis factor (TNF-alpha) in lymph node tissue from 15 patients with classic Hodgkin's lymphoma (c-HL) and one with lymphocyte predominance (LP) HL.
T8 608-985 Sentence denotes We used real-time quantitative polymerase chain reaction (RQ-PCR) to investigate mRNA expression for interleukin (IL)-1alpha, IL-1beta, IL-2, IL-4, IL-5, IL-8, IL-12p35, IL-12p40, IL-13, IL-15, interferon (IFN)-gamma and tumor necrosis factor (TNF-alpha) in lymph node tissue from 15 patients with classic Hodgkin's lymphoma (c-HL) and one with lymphocyte predominance (LP) HL.
T9 986-1053 Sentence denotes HL-derived cell lines L1236, L540, and L428 were also investigated.
T9 986-1053 Sentence denotes HL-derived cell lines L1236, L540, and L428 were also investigated.
T10 1054-1209 Sentence denotes Reactive lymphatic tissue (n=6) and peripheral blood mononuclear cells (PBMC) from healthy donors (n=4) before and after stimulation were used as controls.
T10 1054-1209 Sentence denotes Reactive lymphatic tissue (n=6) and peripheral blood mononuclear cells (PBMC) from healthy donors (n=4) before and after stimulation were used as controls.
T11 1210-1304 Sentence denotes In 5 c-HL samples the cytokine expression in T lymphocytes was also studied by flow cytometry.
T11 1210-1304 Sentence denotes In 5 c-HL samples the cytokine expression in T lymphocytes was also studied by flow cytometry.
T12 1305-1313 Sentence denotes RESULTS:
T12 1305-1313 Sentence denotes RESULTS:
T13 1314-1365 Sentence denotes All c-HL samples (but not LP) expressed IL-13 mRNA.
T13 1314-1365 Sentence denotes All c-HL samples (but not LP) expressed IL-13 mRNA.
T14 1366-1449 Sentence denotes This cytokine was not found in non-stimulated PBMC or in reactive lymphatic tissue.
T14 1366-1449 Sentence denotes This cytokine was not found in non-stimulated PBMC or in reactive lymphatic tissue.
T15 1450-1573 Sentence denotes Expression of IL-10, IL-1beta, IL-15 and IL-12p35 mRNA was higher in HL samples than in PBMC and reactive lymphatic tissue.
T15 1450-1573 Sentence denotes Expression of IL-10, IL-1beta, IL-15 and IL-12p35 mRNA was higher in HL samples than in PBMC and reactive lymphatic tissue.
T16 1574-1711 Sentence denotes Expression of IL-10, IL-1beta, TNF-alpha and IFN-gamma mRNA was significantly higher in the EBV+ HL samples (n=6) than in the EBV- cases.
T16 1574-1711 Sentence denotes Expression of IL-10, IL-1beta, TNF-alpha and IFN-gamma mRNA was significantly higher in the EBV+ HL samples (n=6) than in the EBV- cases.
T17 1712-1798 Sentence denotes All HL cell lines showed high expression of IL-13, IL-12p35, TNF-alpha and IL-15 mRNA.
T17 1712-1798 Sentence denotes All HL cell lines showed high expression of IL-13, IL-12p35, TNF-alpha and IL-15 mRNA.
T18 1799-1930 Sentence denotes IFNg mRNA levels were high in L428 and L540 cells, IL-10 in L1236 cells and L540 cells, IL-5 in L428 cells and IL-4 in L1236 cells.
T18 1799-1930 Sentence denotes IFNg mRNA levels were high in L428 and L540 cells, IL-10 in L1236 cells and L540 cells, IL-5 in L428 cells and IL-4 in L1236 cells.
T19 1931-1962 Sentence denotes INTERPRETATION AND CONCLUSIONS:
T19 1931-1962 Sentence denotes INTERPRETATION AND CONCLUSIONS:
T20 1963-2043 Sentence denotes Cytokine mRNA levels can be measured by RQ-PCR using a limited amount of tissue.
T20 1963-2043 Sentence denotes Cytokine mRNA levels can be measured by RQ-PCR using a limited amount of tissue.
T21 2044-2272 Sentence denotes This method gives valuable information on biological variation between different HL samples and may contribute to unraveling the complex cytokine network contributing to the clinical and biological heterogeneity of this disease.
T21 2044-2272 Sentence denotes This method gives valuable information on biological variation between different HL samples and may contribute to unraveling the complex cytokine network contributing to the clinical and biological heterogeneity of this disease.