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PubMed:15003892 JSONTXT 7 Projects

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Id Subject Object Predicate Lexical cue
T1 0-131 Sentence denotes Osteopontin is an adhesive factor for myeloma cells and is found in increased levels in plasma from patients with multiple myeloma.
T1 0-131 Sentence denotes Osteopontin is an adhesive factor for myeloma cells and is found in increased levels in plasma from patients with multiple myeloma.
T2 132-158 Sentence denotes BACKGROUND AND OBJECTIVES:
T2 132-158 Sentence denotes BACKGROUND AND OBJECTIVES:
T3 159-307 Sentence denotes Osteopontin (OPN) is a non-collagenous matrix protein produced by various cells including osteoblasts, osteoclasts and several types of tumor cells.
T3 159-307 Sentence denotes Osteopontin (OPN) is a non-collagenous matrix protein produced by various cells including osteoblasts, osteoclasts and several types of tumor cells.
T4 308-466 Sentence denotes It is involved in a number of physiologic and pathologic events including adhesion, angiogenesis, apoptosis, inflammation, wound healing and tumor metastasis.
T4 308-466 Sentence denotes It is involved in a number of physiologic and pathologic events including adhesion, angiogenesis, apoptosis, inflammation, wound healing and tumor metastasis.
T5 467-538 Sentence denotes We wanted to investigate the potential role of OPN in multiple myeloma.
T5 467-538 Sentence denotes We wanted to investigate the potential role of OPN in multiple myeloma.
T6 539-558 Sentence denotes DESIGN AND METHODS:
T6 539-558 Sentence denotes DESIGN AND METHODS:
T7 559-658 Sentence denotes Myeloma cells and stromal cells from myeloma patients were investigated as potential OPN-producers.
T7 559-658 Sentence denotes Myeloma cells and stromal cells from myeloma patients were investigated as potential OPN-producers.
T8 659-754 Sentence denotes Furthermore, OPN was tested in proliferation, migration and adhesion assays with myeloma cells.
T8 659-754 Sentence denotes Furthermore, OPN was tested in proliferation, migration and adhesion assays with myeloma cells.
T9 755-855 Sentence denotes Serum and plasma OPN in myeloma patients were measured by enzyme-linked immunosorbent assay (ELISA).
T9 755-855 Sentence denotes Serum and plasma OPN in myeloma patients were measured by enzyme-linked immunosorbent assay (ELISA).
T10 856-940 Sentence denotes OPN levels were correlated to disease variables at diagnosis and to disease outcome.
T10 856-940 Sentence denotes OPN levels were correlated to disease variables at diagnosis and to disease outcome.
T11 941-949 Sentence denotes RESULTS:
T11 941-949 Sentence denotes RESULTS:
T12 950-1087 Sentence denotes Myeloma cells produce OPN, and stromal cells from myeloma patients express higher levels of OPN than stromal cells from healthy controls.
T12 950-1087 Sentence denotes Myeloma cells produce OPN, and stromal cells from myeloma patients express higher levels of OPN than stromal cells from healthy controls.
T13 1088-1143 Sentence denotes The myeloma cell lines ANBL-6 and INA-6 adhered to OPN.
T13 1088-1143 Sentence denotes The myeloma cell lines ANBL-6 and INA-6 adhered to OPN.
T14 1144-1282 Sentence denotes NOD/SCID mice inoculated with OPN-producing ANBL-6 cells had elevated levels of murine OPN in serum, whereas human OPN was not detectable.
T14 1144-1282 Sentence denotes NOD/SCID mice inoculated with OPN-producing ANBL-6 cells had elevated levels of murine OPN in serum, whereas human OPN was not detectable.
T15 1283-1388 Sentence denotes Plasma and serum levels of OPN were significantly higher in myeloma patients than in healthy individuals.
T15 1283-1388 Sentence denotes Plasma and serum levels of OPN were significantly higher in myeloma patients than in healthy individuals.
T16 1389-1420 Sentence denotes Interpretation and Conclusions.
T16 1389-1420 Sentence denotes Interpretation and Conclusions.
T17 1421-1598 Sentence denotes Myeloma cell lines adhere to OPN, indicating that elevated stromal expression of OPN may be one of the factors responsible for the retention of myeloma cells in the bone marrow.
T17 1421-1598 Sentence denotes Myeloma cell lines adhere to OPN, indicating that elevated stromal expression of OPN may be one of the factors responsible for the retention of myeloma cells in the bone marrow.
T18 1599-1763 Sentence denotes The elevated plasma OPN levels in myeloma patients could be due to both production of OPN by the tumor cells and tumor-induced production of OPN by non-tumor cells.
T18 1599-1763 Sentence denotes The elevated plasma OPN levels in myeloma patients could be due to both production of OPN by the tumor cells and tumor-induced production of OPN by non-tumor cells.