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PubMed:14558084 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-59 Sentence denotes Galectin 3 and its binding protein in rheumatoid arthritis.
T1 0-59 Sentence denotes Galectin 3 and its binding protein in rheumatoid arthritis.
T2 60-70 Sentence denotes OBJECTIVE:
T2 60-70 Sentence denotes OBJECTIVE:
T3 71-380 Sentence denotes To characterize the expression pattern and role of galectin 3 and galectin 3 binding protein (G3BP) in rheumatoid arthritis (RA), in comparison with galectin 1, and to explore whether soluble galectin 3 and G3BP, investigated in serum, synovial fluid, or cell culture supernatant, are associated with disease.
T3 71-380 Sentence denotes To characterize the expression pattern and role of galectin 3 and galectin 3 binding protein (G3BP) in rheumatoid arthritis (RA), in comparison with galectin 1, and to explore whether soluble galectin 3 and G3BP, investigated in serum, synovial fluid, or cell culture supernatant, are associated with disease.
T4 381-389 Sentence denotes METHODS:
T4 381-389 Sentence denotes METHODS:
T5 390-582 Sentence denotes Synovial tissues from patients with RA or osteoarthritis (OA), as well as from healthy controls, were analyzed for galectins 1 and 3 and G3BP by in situ hybridization and immunohistochemistry.
T5 390-582 Sentence denotes Synovial tissues from patients with RA or osteoarthritis (OA), as well as from healthy controls, were analyzed for galectins 1 and 3 and G3BP by in situ hybridization and immunohistochemistry.
T6 583-786 Sentence denotes Levels of galectin 3 and G3BP in serum and synovial fluid from patients with RA and OA and controls, as well as in cell culture supernatants, were determined by enzyme-linked immunosorbent assay (ELISA).
T6 583-786 Sentence denotes Levels of galectin 3 and G3BP in serum and synovial fluid from patients with RA and OA and controls, as well as in cell culture supernatants, were determined by enzyme-linked immunosorbent assay (ELISA).
T7 787-1033 Sentence denotes In vitro, the intracellular expression of galectin 3 in RA and OA synovial fibroblasts after modulation with tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), and anti-CD40 monoclonal antibodies was measured by flow cytometry.
T7 787-1033 Sentence denotes In vitro, the intracellular expression of galectin 3 in RA and OA synovial fibroblasts after modulation with tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), and anti-CD40 monoclonal antibodies was measured by flow cytometry.
T8 1034-1042 Sentence denotes RESULTS:
T8 1034-1042 Sentence denotes RESULTS:
T9 1043-1198 Sentence denotes In RA, galectin 3 messenger RNA and protein stained throughout the synovial membrane, whereas G3BP was particularly expressed at sites of bone destruction.
T9 1043-1198 Sentence denotes In RA, galectin 3 messenger RNA and protein stained throughout the synovial membrane, whereas G3BP was particularly expressed at sites of bone destruction.
T10 1199-1325 Sentence denotes In contrast, the expression of galectin 1 was not uniform in different RA specimens, and was never found at sites of invasion.
T10 1199-1325 Sentence denotes In contrast, the expression of galectin 1 was not uniform in different RA specimens, and was never found at sites of invasion.
T11 1326-1430 Sentence denotes In OA and normal synovial tissues, only a small number of cells were positive for galectins and/or G3BP.
T11 1326-1430 Sentence denotes In OA and normal synovial tissues, only a small number of cells were positive for galectins and/or G3BP.
T12 1431-1541 Sentence denotes Galectin 3 was elevated in RA sera and synovial fluids, whereas G3BP was increased in RA synovial fluids only.
T12 1431-1541 Sentence denotes Galectin 3 was elevated in RA sera and synovial fluids, whereas G3BP was increased in RA synovial fluids only.
T13 1542-1757 Sentence denotes In RA, serum galectin 3 correlated with C-reactive protein levels, whereas G3BP was associated with joint destruction and/or synovial cell activation as measured by the levels of cartilage oligomeric matrix protein.
T13 1542-1757 Sentence denotes In RA, serum galectin 3 correlated with C-reactive protein levels, whereas G3BP was associated with joint destruction and/or synovial cell activation as measured by the levels of cartilage oligomeric matrix protein.
T14 1758-1909 Sentence denotes In vitro, RA synovial fibroblasts showed an increased release of galectin 3 into culture medium, as measured by ELISA, but decreased secretion of G3BP.
T14 1758-1909 Sentence denotes In vitro, RA synovial fibroblasts showed an increased release of galectin 3 into culture medium, as measured by ELISA, but decreased secretion of G3BP.
T15 1910-2048 Sentence denotes In RA synovial fibroblasts with low basal expression of galectin 3, TNFalpha increased its intracellular level in a dose-dependent manner.
T15 1910-2048 Sentence denotes In RA synovial fibroblasts with low basal expression of galectin 3, TNFalpha increased its intracellular level in a dose-dependent manner.
T16 2049-2123 Sentence denotes In contrast, IL-1beta or anti-CD40 monoclonal antibodies showed no effect.
T16 2049-2123 Sentence denotes In contrast, IL-1beta or anti-CD40 monoclonal antibodies showed no effect.
T17 2124-2135 Sentence denotes CONCLUSION:
T17 2124-2135 Sentence denotes CONCLUSION:
T18 2136-2280 Sentence denotes Our data indicate that galectin 3 and G3BP are not only involved in inflammation, but also contribute to the activation of synovial fibroblasts.
T18 2136-2280 Sentence denotes Our data indicate that galectin 3 and G3BP are not only involved in inflammation, but also contribute to the activation of synovial fibroblasts.
T19 2281-2354 Sentence denotes The intracellular accumulation of galectin 3 can be enhanced by TNFalpha.
T19 2281-2354 Sentence denotes The intracellular accumulation of galectin 3 can be enhanced by TNFalpha.
T20 2355-2431 Sentence denotes Thus, galectin 3 and G3BP represent novel markers of disease activity in RA.
T20 2355-2431 Sentence denotes Thus, galectin 3 and G3BP represent novel markers of disease activity in RA.