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Id Subject Object Predicate Lexical cue
T1 0-89 Sentence denotes The chemokine CCL21 modulates lymphocyte recruitment and fibrosis in chronic hepatitis C.
T1 0-89 Sentence denotes The chemokine CCL21 modulates lymphocyte recruitment and fibrosis in chronic hepatitis C.
T2 90-110 Sentence denotes BACKGROUND AND AIMS:
T2 90-110 Sentence denotes BACKGROUND AND AIMS:
T3 111-272 Sentence denotes The chemokines CCL19 and CCL21 bind CCR7, which is involved in the organization of secondary lymphoid tissue and is expressed during chronic tissue inflammation.
T3 111-272 Sentence denotes The chemokines CCL19 and CCL21 bind CCR7, which is involved in the organization of secondary lymphoid tissue and is expressed during chronic tissue inflammation.
T4 273-345 Sentence denotes We investigated the expression of CCL21 and CCR7 in chronic hepatitis C.
T4 273-345 Sentence denotes We investigated the expression of CCL21 and CCR7 in chronic hepatitis C.
T5 346-418 Sentence denotes The effects of CCL21 on hepatic stellate cells (HSCs) were also studied.
T5 346-418 Sentence denotes The effects of CCL21 on hepatic stellate cells (HSCs) were also studied.
T6 419-427 Sentence denotes METHODS:
T6 419-427 Sentence denotes METHODS:
T7 428-511 Sentence denotes Expression of CCL21 was assessed by in situ hybridization and immunohistochemistry.
T7 428-511 Sentence denotes Expression of CCL21 was assessed by in situ hybridization and immunohistochemistry.
T8 512-559 Sentence denotes CCR7 on T cells was analyzed by flow cytometry.
T8 512-559 Sentence denotes CCR7 on T cells was analyzed by flow cytometry.
T9 560-622 Sentence denotes Cultured human HSCs were studied in their activated phenotype.
T9 560-622 Sentence denotes Cultured human HSCs were studied in their activated phenotype.
T10 623-631 Sentence denotes RESULTS:
T10 623-631 Sentence denotes RESULTS:
T11 632-716 Sentence denotes In patients with chronic hepatitis C, expression of CCL21 and CCR7 was up-regulated.
T11 632-716 Sentence denotes In patients with chronic hepatitis C, expression of CCL21 and CCR7 was up-regulated.
T12 717-902 Sentence denotes CCL21 was detected in the portal tracts and around inflammatory lymphoid follicles, in proximity to T lymphocytes and dendritic cells, which contributed to expression of this chemokine.
T12 717-902 Sentence denotes CCL21 was detected in the portal tracts and around inflammatory lymphoid follicles, in proximity to T lymphocytes and dendritic cells, which contributed to expression of this chemokine.
T13 903-984 Sentence denotes Expression of CCR7 was also increased in patients with primary biliary cirrhosis.
T13 903-984 Sentence denotes Expression of CCR7 was also increased in patients with primary biliary cirrhosis.
T14 985-1223 Sentence denotes Intrahepatic CD8(+) T lymphocytes isolated from patients with chronic hepatitis C had a significantly higher percentage of positivity for CCR7 than those from healthy controls, and the expression of CCR7 was associated with that of CXCR3.
T14 985-1223 Sentence denotes Intrahepatic CD8(+) T lymphocytes isolated from patients with chronic hepatitis C had a significantly higher percentage of positivity for CCR7 than those from healthy controls, and the expression of CCR7 was associated with that of CXCR3.
T15 1224-1366 Sentence denotes Cultured HSCs expressed functional CCR7, the activation of which stimulated cell migration and accelerated wound healing in an in vitro model.
T15 1224-1366 Sentence denotes Cultured HSCs expressed functional CCR7, the activation of which stimulated cell migration and accelerated wound healing in an in vitro model.
T16 1367-1560 Sentence denotes Exposure of HSCs to CCL21 triggered several signaling pathways, including extracellular signal-regulated kinase, Akt, and nuclear factor kappaB, resulting in induction of proinflammatory genes.
T16 1367-1560 Sentence denotes Exposure of HSCs to CCL21 triggered several signaling pathways, including extracellular signal-regulated kinase, Akt, and nuclear factor kappaB, resulting in induction of proinflammatory genes.
T17 1561-1573 Sentence denotes CONCLUSIONS:
T17 1561-1573 Sentence denotes CONCLUSIONS:
T18 1574-1806 Sentence denotes Expression of CCL21 during chronic hepatitis C is implicated in the recruitment of T lymphocytes and the organization of inflammatory lymphoid tissue and may promote fibrogenesis in the inflamed areas via activation of CCR7 on HSCs.
T18 1574-1806 Sentence denotes Expression of CCL21 during chronic hepatitis C is implicated in the recruitment of T lymphocytes and the organization of inflammatory lymphoid tissue and may promote fibrogenesis in the inflamed areas via activation of CCR7 on HSCs.