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PubMed:1364116 JSONTXT 10 Projects

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Id Subject Object Predicate Lexical cue
T1 0-106 Sentence denotes Cellular immune and cytokine pathways resulting in tissue factor expression and relevance to septic shock.
T1 0-106 Sentence denotes Cellular immune and cytokine pathways resulting in tissue factor expression and relevance to septic shock.
T2 107-189 Sentence denotes Cells of monocyte lineage serve as effector cells in the cellular immune response.
T2 107-189 Sentence denotes Cells of monocyte lineage serve as effector cells in the cellular immune response.
T3 190-364 Sentence denotes In addition, they respond to LPS and cytokines with activation and expression of inflammatory effector gene products similar to those elicited by the antigen driven response.
T3 190-364 Sentence denotes In addition, they respond to LPS and cytokines with activation and expression of inflammatory effector gene products similar to those elicited by the antigen driven response.
T4 365-505 Sentence denotes The response to antigen proceeds at the T helper cell level through two independent forms of cellular collaboration, contact and lymphokine.
T4 365-505 Sentence denotes The response to antigen proceeds at the T helper cell level through two independent forms of cellular collaboration, contact and lymphokine.
T5 506-608 Sentence denotes We review the control of expression of the Tissue Factor (TF) gene and the function of the TF protein.
T5 506-608 Sentence denotes We review the control of expression of the Tissue Factor (TF) gene and the function of the TF protein.
T6 609-849 Sentence denotes The enhanced initiation of transcription of the TF gene appears to require engagement of a 56 bp LPS Response Element, an enhancer that is engaged by both AP-1 type heterodimeric complexes as well as NF kappa B like heterodimeric complexes.
T6 609-849 Sentence denotes The enhanced initiation of transcription of the TF gene appears to require engagement of a 56 bp LPS Response Element, an enhancer that is engaged by both AP-1 type heterodimeric complexes as well as NF kappa B like heterodimeric complexes.
T7 850-1041 Sentence denotes Dissociation of NF kappa B from Ig kappa B by cytokine and LPS stimulation, and possibly activated T cells, may represent a common pathway to induction of the TF and other inflammatory genes.
T7 850-1041 Sentence denotes Dissociation of NF kappa B from Ig kappa B by cytokine and LPS stimulation, and possibly activated T cells, may represent a common pathway to induction of the TF and other inflammatory genes.
T8 1042-1212 Sentence denotes Enhancement of expression of TF is observed upon adhesion of Mo to endothelial cells and extracellular matrix proteins, as well as upon engagement of leukocyte integrins.
T8 1042-1212 Sentence denotes Enhancement of expression of TF is observed upon adhesion of Mo to endothelial cells and extracellular matrix proteins, as well as upon engagement of leukocyte integrins.
T9 1213-1413 Sentence denotes The biological effects that follow from expression of TF by vascular cells have been resolved by analysis of function aided by the use of recombinant full length TF and truncated surface domain of TF.
T9 1213-1413 Sentence denotes The biological effects that follow from expression of TF by vascular cells have been resolved by analysis of function aided by the use of recombinant full length TF and truncated surface domain of TF.
T10 1414-1707 Sentence denotes The rules of assembly of the cognate ligands of TF, namely the zymogen plasma factors VII and the serine protease factor VIIa, with the soluble surface domain of TF in free solution, in the presence of phospholipid surfaces and cell surface and of the anchored TF molecule have been described.
T10 1414-1707 Sentence denotes The rules of assembly of the cognate ligands of TF, namely the zymogen plasma factors VII and the serine protease factor VIIa, with the soluble surface domain of TF in free solution, in the presence of phospholipid surfaces and cell surface and of the anchored TF molecule have been described.
T11 1708-1956 Sentence denotes It is evident that assembly of the surface domain of TF with VIIa to form the binary TF.VIIa complex induces a significant increase in the Kcat of the catalytic domain of VIIa for small peptidyl substrates and more profoundly for protein substrate.
T11 1708-1956 Sentence denotes It is evident that assembly of the surface domain of TF with VIIa to form the binary TF.VIIa complex induces a significant increase in the Kcat of the catalytic domain of VIIa for small peptidyl substrates and more profoundly for protein substrate.
T12 1957-2114 Sentence denotes This provides substantial evidence for an allosteric effect on the catalytic cleft of VIIa that is imparted by binding to TF, its cognate catalytic cofactor.
T12 1957-2114 Sentence denotes This provides substantial evidence for an allosteric effect on the catalytic cleft of VIIa that is imparted by binding to TF, its cognate catalytic cofactor.
T13 2115-2453 Sentence denotes It is also evident that the TF.VIIa complex is proteolytically active and can activate the zymogen plasma factor X to the serine protease Xa in free solution, inferring that extended substrate recognition by induced structural loci of the TF.VIIa complex are created from either or both proteins to constitute a new recognition structure.
T13 2115-2453 Sentence denotes It is also evident that the TF.VIIa complex is proteolytically active and can activate the zymogen plasma factor X to the serine protease Xa in free solution, inferring that extended substrate recognition by induced structural loci of the TF.VIIa complex are created from either or both proteins to constitute a new recognition structure.
T14 2454-2746 Sentence denotes It is also evident that association of X with charged phospholipid surfaces enhances the proteolytic activation of this zymogen by increasing recognition and susceptibility of the sessile peptide bond deduced from the markedly decreased Km and increased Kcat.(ABSTRACT TRUNCATED AT 400 WORDS)
T14 2454-2746 Sentence denotes It is also evident that association of X with charged phospholipid surfaces enhances the proteolytic activation of this zymogen by increasing recognition and susceptibility of the sessile peptide bond deduced from the markedly decreased Km and increased Kcat.(ABSTRACT TRUNCATED AT 400 WORDS)