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PubMed:1328757 JSONTXT 2 Projects

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Id Subject Object Predicate Lexical cue
T1 0-102 Sentence denotes Interleukin-1 and tumor necrosis factor and their naturally occurring antagonists during hemodialysis.
T1 0-102 Sentence denotes Interleukin-1 and tumor necrosis factor and their naturally occurring antagonists during hemodialysis.
T2 103-230 Sentence denotes Cytokines are polypeptides which possess various biological properties affecting host defense function and response to disease.
T2 103-230 Sentence denotes Cytokines are polypeptides which possess various biological properties affecting host defense function and response to disease.
T3 231-387 Sentence denotes Two cytokines, interleukin-1 (IL-1) and tumor necrosis factor (TNF) induce fever, hypotension and inflammation when injected into animals or human subjects.
T3 231-387 Sentence denotes Two cytokines, interleukin-1 (IL-1) and tumor necrosis factor (TNF) induce fever, hypotension and inflammation when injected into animals or human subjects.
T4 388-500 Sentence denotes In humans injected with either IL-1 or TNF, sleepiness, generalized myalgias and headache are commonly reported.
T4 388-500 Sentence denotes In humans injected with either IL-1 or TNF, sleepiness, generalized myalgias and headache are commonly reported.
T5 501-661 Sentence denotes Therefore, the production of IL-1 and TNF as a consequence of hemodialysis was hypothesized to explain, in part, the signs and symptoms of the dialysis patient.
T5 501-661 Sentence denotes Therefore, the production of IL-1 and TNF as a consequence of hemodialysis was hypothesized to explain, in part, the signs and symptoms of the dialysis patient.
T6 662-847 Sentence denotes Laboratory studies confirmed that the activation of complement and the passage of microbial products from the dialysate into the blood compartment induces the synthesis of IL-1 and TNF.
T6 662-847 Sentence denotes Laboratory studies confirmed that the activation of complement and the passage of microbial products from the dialysate into the blood compartment induces the synthesis of IL-1 and TNF.
T7 848-1115 Sentence denotes Although elevated production of IL-1 and TNF in the mononuclear cells and in the circulation of patients during and after hemodialysis have been reported, these levels have not been a consistent finding and are low compared to the amount of dialysis related symptoms.
T7 848-1115 Sentence denotes Although elevated production of IL-1 and TNF in the mononuclear cells and in the circulation of patients during and after hemodialysis have been reported, these levels have not been a consistent finding and are low compared to the amount of dialysis related symptoms.
T8 1116-1282 Sentence denotes Recent studies, however, demonstrate that IL-1 and TNF have naturally occurring antagonists which specifically block the biological activities of these two cytokines.
T8 1116-1282 Sentence denotes Recent studies, however, demonstrate that IL-1 and TNF have naturally occurring antagonists which specifically block the biological activities of these two cytokines.
T9 1283-1376 Sentence denotes The IL-1 receptor antagonist blocks IL-1 binding to cells but has no IL-1 activity of itself.
T9 1283-1376 Sentence denotes The IL-1 receptor antagonist blocks IL-1 binding to cells but has no IL-1 activity of itself.
T10 1377-1489 Sentence denotes Soluble TNF receptors prevent TNF from binding to its cellular receptors and hence serve as anti-TNF mechanisms.
T10 1377-1489 Sentence denotes Soluble TNF receptors prevent TNF from binding to its cellular receptors and hence serve as anti-TNF mechanisms.
T11 1490-1750 Sentence denotes These inhibitors are currently in clinical trials for sepsis where efficacy has been demonstrated; however, the IL-1 receptor antagonist (IL-1Ra) and soluble TNF receptors (sTNFR) are likely candidates for use in dialysis patients with symptomatic hypotension.
T11 1490-1750 Sentence denotes These inhibitors are currently in clinical trials for sepsis where efficacy has been demonstrated; however, the IL-1 receptor antagonist (IL-1Ra) and soluble TNF receptors (sTNFR) are likely candidates for use in dialysis patients with symptomatic hypotension.
T12 1751-1874 Sentence denotes Although levels of IL-1Ra and sTNFR are elevated in patients on HD, these levels reflect the host response to inflammation.
T12 1751-1874 Sentence denotes Although levels of IL-1Ra and sTNFR are elevated in patients on HD, these levels reflect the host response to inflammation.
T13 1875-2042 Sentence denotes It is unclear whether acute or chronic administration of IL-1Ra or sTNFR will be beneficial in treating some of the acute or chronic changes seen in dialysis patients.
T13 1875-2042 Sentence denotes It is unclear whether acute or chronic administration of IL-1Ra or sTNFR will be beneficial in treating some of the acute or chronic changes seen in dialysis patients.