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PubMed:1328390 JSONTXT 2 Projects

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Id Subject Object Predicate Lexical cue
T1 0-116 Sentence denotes Alpha-1-antichymotrypsin inhibits the NADPH oxidase-enzyme complex in phorbol ester-stimulated neutrophil membranes.
T1 0-116 Sentence denotes Alpha-1-antichymotrypsin inhibits the NADPH oxidase-enzyme complex in phorbol ester-stimulated neutrophil membranes.
T2 117-309 Sentence denotes The generation of superoxide anion and release of granule contents are essential to the bactericidal function of neutrophils, but may also contribute to host tissue damage during inflammation.
T2 117-309 Sentence denotes The generation of superoxide anion and release of granule contents are essential to the bactericidal function of neutrophils, but may also contribute to host tissue damage during inflammation.
T3 310-333 Sentence denotes In previous studies (J.
T3 310-333 Sentence denotes In previous studies (J.
T4 334-342 Sentence denotes Immunol.
T4 334-342 Sentence denotes Immunol.
T5 343-536 Sentence denotes 146:2388), we have demonstrated that the acute phase reactant alpha-1-antichymotrypsin (ACT), a potent inhibitor of the serine protease cathepsin G, also suppresses superoxide anion generation.
T5 343-536 Sentence denotes 146:2388), we have demonstrated that the acute phase reactant alpha-1-antichymotrypsin (ACT), a potent inhibitor of the serine protease cathepsin G, also suppresses superoxide anion generation.
T6 537-689 Sentence denotes The inhibitory effect of ACT was not directly linked to its antiproteolytic activity and may reflect interaction at a site other than its reactive loop.
T6 537-689 Sentence denotes The inhibitory effect of ACT was not directly linked to its antiproteolytic activity and may reflect interaction at a site other than its reactive loop.
T7 690-898 Sentence denotes To further characterize the mechanism of inhibition, we investigated the direct effects of ACT on the NADPH oxidase enzyme complex and the signaling pathways that regulate motivation of the respiratory burst.
T7 690-898 Sentence denotes To further characterize the mechanism of inhibition, we investigated the direct effects of ACT on the NADPH oxidase enzyme complex and the signaling pathways that regulate motivation of the respiratory burst.
T8 899-1040 Sentence denotes We present evidence that ACT does not intefer with agonist-stimulated calcium mobilization or translocation and activity of protein kinase C.
T8 899-1040 Sentence denotes We present evidence that ACT does not intefer with agonist-stimulated calcium mobilization or translocation and activity of protein kinase C.
T9 1041-1162 Sentence denotes ACT was an effective inhibitor of superoxide anion generation in membrane preparations isolated from PMA-activated cells.
T9 1041-1162 Sentence denotes ACT was an effective inhibitor of superoxide anion generation in membrane preparations isolated from PMA-activated cells.
T10 1163-1276 Sentence denotes These results support the notion that ACT is acting on a component of the active assembled NADPH oxidase complex.
T10 1163-1276 Sentence denotes These results support the notion that ACT is acting on a component of the active assembled NADPH oxidase complex.
T11 1277-1438 Sentence denotes Thus, ACT may have an important role in regulation of specific aspects of the inflammatory processes and the modulation of toxic oxygen-based host tissue damage.
T11 1277-1438 Sentence denotes Thus, ACT may have an important role in regulation of specific aspects of the inflammatory processes and the modulation of toxic oxygen-based host tissue damage.