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PubMed:1327803 JSONTXT 10 Projects

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Id Subject Object Predicate Lexical cue
T1 0-98 Sentence denotes Leukotriene B4 transcriptionally activates interleukin-6 expression involving NK-chi B and NF-IL6.
T1 0-98 Sentence denotes Leukotriene B4 transcriptionally activates interleukin-6 expression involving NK-chi B and NF-IL6.
T2 99-177 Sentence denotes Leukotriene B4 (LTB4) is a notable participant in inflammation and chemotaxis.
T2 99-177 Sentence denotes Leukotriene B4 (LTB4) is a notable participant in inflammation and chemotaxis.
T3 178-333 Sentence denotes It is, however, still unclear whether LTB4 acts in this regard directly or indirectly by stimulating the release of chemotactic and inflammatory cytokines.
T3 178-333 Sentence denotes It is, however, still unclear whether LTB4 acts in this regard directly or indirectly by stimulating the release of chemotactic and inflammatory cytokines.
T4 334-476 Sentence denotes Here we report that LTB4 induces synthesis of interleukin (IL)-6 by human blood monocytes through transcriptional activation of the IL-6 gene.
T4 334-476 Sentence denotes Here we report that LTB4 induces synthesis of interleukin (IL)-6 by human blood monocytes through transcriptional activation of the IL-6 gene.
T5 477-747 Sentence denotes We furthermore demonstrate that this process involves activation of the transcription factor NF-chi B and, to a lesser extent, of NF-IL6, while the activity of the transcription factor AP-1, shown to otherwise confer IL-6 inducibility, appeared to be unaffected by LTB4.
T5 477-747 Sentence denotes We furthermore demonstrate that this process involves activation of the transcription factor NF-chi B and, to a lesser extent, of NF-IL6, while the activity of the transcription factor AP-1, shown to otherwise confer IL-6 inducibility, appeared to be unaffected by LTB4.
T6 748-889 Sentence denotes Involvement of NF-chi B and NF-IL6 in induction of IL-6 transcription by monocytes was demonstrated using deleted forms of the IL-6 promoter.
T6 748-889 Sentence denotes Involvement of NF-chi B and NF-IL6 in induction of IL-6 transcription by monocytes was demonstrated using deleted forms of the IL-6 promoter.
T7 890-1063 Sentence denotes Activation of the IL-6 promoter by LTB4 was not only associated with accumulation of the respective transcripts but resulted in synthesis of functional IL-6 protein as well.
T7 890-1063 Sentence denotes Activation of the IL-6 promoter by LTB4 was not only associated with accumulation of the respective transcripts but resulted in synthesis of functional IL-6 protein as well.
T8 1064-1218 Sentence denotes In addition, LTB4 mediated transactivation of a heterologous promoter construct containing the NF-chi B or the NF-IL6 enhancer, but not the AP-1 enhancer.
T8 1064-1218 Sentence denotes In addition, LTB4 mediated transactivation of a heterologous promoter construct containing the NF-chi B or the NF-IL6 enhancer, but not the AP-1 enhancer.
T9 1219-1412 Sentence denotes The signaling events mediating this effect appeared to involve the release of H2O2, since LTB4 failed to induce NF-chi B or NF-IL6 in the presence of the scavenger of H2O2, N-acetyl-L-cysteine.
T9 1219-1412 Sentence denotes The signaling events mediating this effect appeared to involve the release of H2O2, since LTB4 failed to induce NF-chi B or NF-IL6 in the presence of the scavenger of H2O2, N-acetyl-L-cysteine.