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PubMed:1327800 JSONTXT 2 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-194 Sentence denotes Limited involvement of interleukin-6 in the pathogenesis of lethal septic shock as revealed by the effect of monoclonal antibodies against interleukin-6 or its receptor in various murine models.
T1 0-194 Sentence denotes Limited involvement of interleukin-6 in the pathogenesis of lethal septic shock as revealed by the effect of monoclonal antibodies against interleukin-6 or its receptor in various murine models.
T2 195-397 Sentence denotes Several studies in human patients and in laboratory animals have revealed a correlation between serum interleukin (IL)-6 levels and outcome in clinical sepsis and in related animal models, respectively.
T2 195-397 Sentence denotes Several studies in human patients and in laboratory animals have revealed a correlation between serum interleukin (IL)-6 levels and outcome in clinical sepsis and in related animal models, respectively.
T3 398-588 Sentence denotes In the present study, two monoclonal antibodies were used to investigate the contribution of IL-6 in the lethal action of tumor necrosis factor (TNF) and of lipopolysaccharide (LPS) in mice.
T3 398-588 Sentence denotes In the present study, two monoclonal antibodies were used to investigate the contribution of IL-6 in the lethal action of tumor necrosis factor (TNF) and of lipopolysaccharide (LPS) in mice.
T4 589-711 Sentence denotes We studied the potential protective properties of an anti-murine (m) IL-6 antibody and of an anti-mIL-6 receptor antibody.
T4 589-711 Sentence denotes We studied the potential protective properties of an anti-murine (m) IL-6 antibody and of an anti-mIL-6 receptor antibody.
T5 712-846 Sentence denotes In controlled experiments, we observed that both monoclonal antibodies conferred a dose-dependent protection to a lethal dose of mTNF.
T5 712-846 Sentence denotes In controlled experiments, we observed that both monoclonal antibodies conferred a dose-dependent protection to a lethal dose of mTNF.
T6 847-1013 Sentence denotes Detailed studies with the monoclonal antibodies indicate, however, that protection was no longer observed when the mTNF dose was slightly higher than the lethal dose.
T6 847-1013 Sentence denotes Detailed studies with the monoclonal antibodies indicate, however, that protection was no longer observed when the mTNF dose was slightly higher than the lethal dose.
T7 1014-1185 Sentence denotes Likewise, the anti-IL-6 monoclonal antibody protected against injections of LPS at a lethal-dose concentration, but here too failed to protect against higher doses of LPS.
T7 1014-1185 Sentence denotes Likewise, the anti-IL-6 monoclonal antibody protected against injections of LPS at a lethal-dose concentration, but here too failed to protect against higher doses of LPS.
T8 1186-1357 Sentence denotes The anti-IL-6 monoclonal antibody was unable to protect against mTNF in mice sensitized by galactosamine, the corticoid receptor antagonist RU38486 or human (h) IL-1 beta.
T8 1186-1357 Sentence denotes The anti-IL-6 monoclonal antibody was unable to protect against mTNF in mice sensitized by galactosamine, the corticoid receptor antagonist RU38486 or human (h) IL-1 beta.
T9 1358-1425 Sentence denotes Protection did not correlate with the serum concentrations of IL-6.
T9 1358-1425 Sentence denotes Protection did not correlate with the serum concentrations of IL-6.
T10 1426-1523 Sentence denotes Finally, we demonstrate that hIL-6 injection did not change the sensitivity of mice towards mTNF.
T10 1426-1523 Sentence denotes Finally, we demonstrate that hIL-6 injection did not change the sensitivity of mice towards mTNF.
T11 1524-1703 Sentence denotes We conclude that, although IL-6 levels may be of value as a marker for the outcome in septic shock, this cytokine contributes only marginally in the pathogenesis leading to death.
T11 1524-1703 Sentence denotes We conclude that, although IL-6 levels may be of value as a marker for the outcome in septic shock, this cytokine contributes only marginally in the pathogenesis leading to death.
T12 1704-1835 Sentence denotes The small, but real, contribution of IL-6 in some situations might be due to its ability to up-regulate the level of TNF receptors.
T12 1704-1835 Sentence denotes The small, but real, contribution of IL-6 in some situations might be due to its ability to up-regulate the level of TNF receptors.