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PubMed:12851408 JSONTXT 42 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-93 Sentence denotes Crystal structure and carbohydrate-binding properties of the human cartilage glycoprotein-39.
T1 0-93 Sentence denotes Crystal structure and carbohydrate-binding properties of the human cartilage glycoprotein-39.
T2 94-216 Sentence denotes The human cartilage glycoprotein-39 (HCgp-39 or YKL40) is expressed by synovial cells and macrophages during inflammation.
T2 94-216 Sentence denotes The human cartilage glycoprotein-39 (HCgp-39 or YKL40) is expressed by synovial cells and macrophages during inflammation.
T3 217-259 Sentence denotes Its precise physiological role is unknown.
T3 217-259 Sentence denotes Its precise physiological role is unknown.
T4 260-423 Sentence denotes However, it has been proposed that HCgp-39 acts as an autoantigen in rheumatoid arthritis, and high expression levels have been associated with cancer development.
T4 260-423 Sentence denotes However, it has been proposed that HCgp-39 acts as an autoantigen in rheumatoid arthritis, and high expression levels have been associated with cancer development.
T5 424-549 Sentence denotes HCgp-39 shares high sequence homology with family 18 chitinases, and although it binds to chitin it lacks enzymatic activity.
T5 424-549 Sentence denotes HCgp-39 shares high sequence homology with family 18 chitinases, and although it binds to chitin it lacks enzymatic activity.
T6 550-687 Sentence denotes The crystal structure of HCgp-39 shows that the protein displays a (beta/alpha)8-barrel fold with an insertion of an alpha + beta domain.
T6 550-687 Sentence denotes The crystal structure of HCgp-39 shows that the protein displays a (beta/alpha)8-barrel fold with an insertion of an alpha + beta domain.
T7 688-809 Sentence denotes A 43-A long carbohydrate-binding cleft is present at the C-terminal side of the beta-strands in the (beta/alpha)8 barrel.
T7 688-809 Sentence denotes A 43-A long carbohydrate-binding cleft is present at the C-terminal side of the beta-strands in the (beta/alpha)8 barrel.
T8 810-912 Sentence denotes Binding of chitin fragments of different lengths identified nine sugar-binding subsites in the groove.
T8 810-912 Sentence denotes Binding of chitin fragments of different lengths identified nine sugar-binding subsites in the groove.
T9 913-1026 Sentence denotes Protein-carbohydrate interactions are mainly mediated by stacking of side chains of aromatic amino acid residues.
T9 913-1026 Sentence denotes Protein-carbohydrate interactions are mainly mediated by stacking of side chains of aromatic amino acid residues.
T10 1027-1131 Sentence denotes Surprisingly, the specificity of chitin binding to HCgp-39 depends on the length of the oligosaccharide.
T10 1027-1131 Sentence denotes Surprisingly, the specificity of chitin binding to HCgp-39 depends on the length of the oligosaccharide.
T11 1132-1266 Sentence denotes Although chitin disaccharides tend to occupy the distal subsites, longer chains bind preferably to the central subsites in the groove.
T11 1132-1266 Sentence denotes Although chitin disaccharides tend to occupy the distal subsites, longer chains bind preferably to the central subsites in the groove.
T12 1267-1462 Sentence denotes Despite the absence of enzymatic activity, long chitin fragments are distorted upon binding, with the GlcNAc at subsite -1 in a boat conformation, similar to what has been observed in chitinases.
T12 1267-1462 Sentence denotes Despite the absence of enzymatic activity, long chitin fragments are distorted upon binding, with the GlcNAc at subsite -1 in a boat conformation, similar to what has been observed in chitinases.
T13 1463-1537 Sentence denotes The presence of chitin in the human body has never been documented so far.
T13 1463-1537 Sentence denotes The presence of chitin in the human body has never been documented so far.
T14 1538-1717 Sentence denotes However, the binding features observed in the complex structures suggest that either chitin or a closely related oligosaccharide could act as the physiological ligand for HCgp-39.
T14 1538-1717 Sentence denotes However, the binding features observed in the complex structures suggest that either chitin or a closely related oligosaccharide could act as the physiological ligand for HCgp-39.