> top > projects > Inflammaging > docs > PubMed:12359166 > annotations
Inflammaging  

PubMed:12359166 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-106 Sentence denotes Contribution of interleukin 17 to human cartilage degradation and synovial inflammation in osteoarthritis.
T1 0-106 Sentence denotes Contribution of interleukin 17 to human cartilage degradation and synovial inflammation in osteoarthritis.
T2 107-117 Sentence denotes OBJECTIVE:
T2 107-117 Sentence denotes OBJECTIVE:
T3 118-306 Sentence denotes To compare the effect of interleukin (IL)-17, IL-1beta and TNF-alpha on chemokine production by human chondrocytes and synovial fibroblasts isolated from patients with osteoarthritis (OA).
T3 118-306 Sentence denotes To compare the effect of interleukin (IL)-17, IL-1beta and TNF-alpha on chemokine production by human chondrocytes and synovial fibroblasts isolated from patients with osteoarthritis (OA).
T4 307-540 Sentence denotes The expression of IL-1beta mRNA by OA chondrocytes was also assessed, as well as the presence and expression of IL-17 receptor (IL-17R) in OA chondrocytes and synovial fibroblasts after stimulation with IL-17, IL-1beta and TNF-alpha.
T4 307-540 Sentence denotes The expression of IL-1beta mRNA by OA chondrocytes was also assessed, as well as the presence and expression of IL-17 receptor (IL-17R) in OA chondrocytes and synovial fibroblasts after stimulation with IL-17, IL-1beta and TNF-alpha.
T5 541-548 Sentence denotes DESIGN:
T5 541-548 Sentence denotes DESIGN:
T6 549-677 Sentence denotes Synovial fibroblasts and chondrocytes isolated from patients with OA were stimulated in vitro with IL-17, IL-1beta or TNF-alpha.
T6 549-677 Sentence denotes Synovial fibroblasts and chondrocytes isolated from patients with OA were stimulated in vitro with IL-17, IL-1beta or TNF-alpha.
T7 678-811 Sentence denotes Supernatants were collected and immunoassayed for the presence of IL-8, GRO-alpha (CXC chemokines) and MCP-1, RANTES (CC chemokines).
T7 678-811 Sentence denotes Supernatants were collected and immunoassayed for the presence of IL-8, GRO-alpha (CXC chemokines) and MCP-1, RANTES (CC chemokines).
T8 812-899 Sentence denotes The cells were used to detect the presence of IL-17R and the expression of IL-17R mRNA.
T8 812-899 Sentence denotes The cells were used to detect the presence of IL-17R and the expression of IL-17R mRNA.
T9 900-989 Sentence denotes Stimulated chondrocytes were also used to detect IL-1beta production and mRNA expression.
T9 900-989 Sentence denotes Stimulated chondrocytes were also used to detect IL-1beta production and mRNA expression.
T10 990-1144 Sentence denotes RESULTS: IL-17 upregulated the release of IL-8 and GRO-alpha both by synovial fibroblasts and chondrocytes, and the release of MCP-1 only by chondrocytes.
T10 990-1144 Sentence denotes RESULTS: IL-17 upregulated the release of IL-8 and GRO-alpha both by synovial fibroblasts and chondrocytes, and the release of MCP-1 only by chondrocytes.
T11 1145-1319 Sentence denotes IL-17 was a weaker stimulator than IL-1beta and TNF-alpha, except for GRO-alpha release which was maximally upregulated by IL-1beta, less by IL-17 and minimally by TNF-alpha.
T11 1145-1319 Sentence denotes IL-17 was a weaker stimulator than IL-1beta and TNF-alpha, except for GRO-alpha release which was maximally upregulated by IL-1beta, less by IL-17 and minimally by TNF-alpha.
T12 1320-1405 Sentence denotes When compared to IL-1beta, IL-17 was more active on chondrocytes than on fibroblasts.
T12 1320-1405 Sentence denotes When compared to IL-1beta, IL-17 was more active on chondrocytes than on fibroblasts.
T13 1406-1532 Sentence denotes In chondrocytes the expression of IL-1beta mRNA was enhanced by IL-17 and TNF-alpha, with a maximum level reached by IL-1beta.
T13 1406-1532 Sentence denotes In chondrocytes the expression of IL-1beta mRNA was enhanced by IL-17 and TNF-alpha, with a maximum level reached by IL-1beta.
T14 1533-1597 Sentence denotes IL-17 and TNF-alpha stimulated IL-1beta release in few subjects.
T14 1533-1597 Sentence denotes IL-17 and TNF-alpha stimulated IL-1beta release in few subjects.
T15 1598-1703 Sentence denotes Neither IL-17, IL-1beta nor TNF-alpha modulated the presence of IL-17R and the expression of IL-17R mRNA.
T15 1598-1703 Sentence denotes Neither IL-17, IL-1beta nor TNF-alpha modulated the presence of IL-17R and the expression of IL-17R mRNA.
T16 1704-1716 Sentence denotes CONCLUSIONS:
T16 1704-1716 Sentence denotes CONCLUSIONS:
T17 1717-1968 Sentence denotes These data suggest that IL-17 could contribute to cartilage breakdown and synovial infiltration in OA by inducing both the release of chemokines by chondrocytes and synovial fibroblasts and, in a less extent, the synthesis of IL-1beta by chondrocytes.
T17 1717-1968 Sentence denotes These data suggest that IL-17 could contribute to cartilage breakdown and synovial infiltration in OA by inducing both the release of chemokines by chondrocytes and synovial fibroblasts and, in a less extent, the synthesis of IL-1beta by chondrocytes.