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PubMed:12217812 JSONTXT 6 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-143 Sentence denotes Idiotypic vaccination for B-cell malignancies as a model for therapeutic cancer vaccines: from prototype protein to second generation vaccines.
T1 0-143 Sentence denotes Idiotypic vaccination for B-cell malignancies as a model for therapeutic cancer vaccines: from prototype protein to second generation vaccines.
T2 144-170 Sentence denotes BACKGROUND AND OBJECTIVES:
T2 144-170 Sentence denotes BACKGROUND AND OBJECTIVES:
T3 171-345 Sentence denotes Cancer vaccines are aimed at inducing tumor-specific immunity by immunizing patients with tumor cells or their antigenic components, known as tumor-associated antigens (TAA).
T3 171-345 Sentence denotes Cancer vaccines are aimed at inducing tumor-specific immunity by immunizing patients with tumor cells or their antigenic components, known as tumor-associated antigens (TAA).
T4 346-480 Sentence denotes Antigens which are either mutated or selectively or abundantly expressed in malignant, but not in normal, cells are considered as TAA.
T4 346-480 Sentence denotes Antigens which are either mutated or selectively or abundantly expressed in malignant, but not in normal, cells are considered as TAA.
T5 481-661 Sentence denotes Each patient's B-cell malignancy is usually derived from a single expanded B-cell clone, which expresses an immunoglobulin (Ig) with a unique idiotype (Id, variable regions of Ig).
T5 481-661 Sentence denotes Each patient's B-cell malignancy is usually derived from a single expanded B-cell clone, which expresses an immunoglobulin (Ig) with a unique idiotype (Id, variable regions of Ig).
T6 662-759 Sentence denotes Therefore, Id can be regarded as a TAA and a potential target in clinical vaccination approaches.
T6 662-759 Sentence denotes Therefore, Id can be regarded as a TAA and a potential target in clinical vaccination approaches.
T7 760-1120 Sentence denotes Although use of tumor-derived Id as an immunogen to elicit antitumor immunity against B-cell malignancies is an attractive idea, the broader use of idiotypic vaccines has been hampered by the fact that autologous Id is not only a weakly immunogenic, self antigen, but is also patient-specific so that the vaccine must be individually prepared for each patient.
T7 760-1120 Sentence denotes Although use of tumor-derived Id as an immunogen to elicit antitumor immunity against B-cell malignancies is an attractive idea, the broader use of idiotypic vaccines has been hampered by the fact that autologous Id is not only a weakly immunogenic, self antigen, but is also patient-specific so that the vaccine must be individually prepared for each patient.
T8 1121-1446 Sentence denotes In this review we will first summarize the latest data from the clinical tests of experimental idiotypic vaccines and discuss issues relevant to the clinical application of cancer vaccines in general; we will then critically review new trends and achievements in the development of the second generation vaccine formulations.
T8 1121-1446 Sentence denotes In this review we will first summarize the latest data from the clinical tests of experimental idiotypic vaccines and discuss issues relevant to the clinical application of cancer vaccines in general; we will then critically review new trends and achievements in the development of the second generation vaccine formulations.
T9 1447-1480 Sentence denotes EVIDENCE AND INFORMATION SOURCES:
T9 1447-1480 Sentence denotes EVIDENCE AND INFORMATION SOURCES:
T10 1481-1643 Sentence denotes The authors of the present review are currently working in the field of B-cell tumor immunotherapy and have contributed original papers to peer-reviewed journals.
T10 1481-1643 Sentence denotes The authors of the present review are currently working in the field of B-cell tumor immunotherapy and have contributed original papers to peer-reviewed journals.
T11 1644-1792 Sentence denotes The material analyzed in the present review includes articles and abstracts published in journals covered by the Science Citation Index and Medline.
T11 1644-1792 Sentence denotes The material analyzed in the present review includes articles and abstracts published in journals covered by the Science Citation Index and Medline.
T12 1793-1806 Sentence denotes STATE OF ART:
T12 1793-1806 Sentence denotes STATE OF ART:
T13 1807-1988 Sentence denotes The results from a number of experimental models and clinical trials have demonstrated that vaccination with tumor-derived Id can induce immune responses directed against the tumor.
T13 1807-1988 Sentence denotes The results from a number of experimental models and clinical trials have demonstrated that vaccination with tumor-derived Id can induce immune responses directed against the tumor.
T14 1989-2175 Sentence denotes Idiotypic vaccines can be divided into two types, although both are at the experimental stage: traditional and second generation, based on the methods of production and vaccine delivery.
T14 1989-2175 Sentence denotes Idiotypic vaccines can be divided into two types, although both are at the experimental stage: traditional and second generation, based on the methods of production and vaccine delivery.
T15 2176-2400 Sentence denotes Second generation vaccines utilizing genetically engineered protein and DNA formulations have, for the first time, opened up the possibility of streamlining production of simpler and effective custom-made idiotypic vaccines.
T15 2176-2400 Sentence denotes Second generation vaccines utilizing genetically engineered protein and DNA formulations have, for the first time, opened up the possibility of streamlining production of simpler and effective custom-made idiotypic vaccines.
T16 2401-2638 Sentence denotes The use of various adjuvants and exogenous carriers is being replaced by more potent genetic carriers which target Id and various co-stimulatory molecules to professional antigen presenting cells (APC), particularly dendritic cells (DC).
T16 2401-2638 Sentence denotes The use of various adjuvants and exogenous carriers is being replaced by more potent genetic carriers which target Id and various co-stimulatory molecules to professional antigen presenting cells (APC), particularly dendritic cells (DC).
T17 2639-2652 Sentence denotes PERSPECTIVES:
T17 2639-2652 Sentence denotes PERSPECTIVES:
T18 2653-2776 Sentence denotes Id is the only widely accepted tumor marker and is a promising therapeutic target for immunotherapy of B-cell malignancies.
T18 2653-2776 Sentence denotes Id is the only widely accepted tumor marker and is a promising therapeutic target for immunotherapy of B-cell malignancies.
T19 2777-2997 Sentence denotes It has been unequivocally established that Id vaccination of patients with follicular lymphoma administered when patients have minimal residual disease, has antitumor effect and potential to improve the clinical outcome.
T19 2777-2997 Sentence denotes It has been unequivocally established that Id vaccination of patients with follicular lymphoma administered when patients have minimal residual disease, has antitumor effect and potential to improve the clinical outcome.
T20 2998-3174 Sentence denotes Consequently, the applicability of Id vaccines for other B-cell malignancies such as chronic lymphocytic leukemia, mantle cell lymphoma and multiple myeloma needs to be tested.
T20 2998-3174 Sentence denotes Consequently, the applicability of Id vaccines for other B-cell malignancies such as chronic lymphocytic leukemia, mantle cell lymphoma and multiple myeloma needs to be tested.
T21 3175-3405 Sentence denotes Idiotypic vaccines should be tailored to target preferentially various subsets of immune cells, such as DCs, which would up take and properly process and present Id, activating both arms of the immune system, humoral and cellular.
T21 3175-3405 Sentence denotes Idiotypic vaccines should be tailored to target preferentially various subsets of immune cells, such as DCs, which would up take and properly process and present Id, activating both arms of the immune system, humoral and cellular.
T22 3406-3582 Sentence denotes Moreover, the vaccine should induce the production of a milieu of inflammatory cytokines and lymphokines at the delivery site to elicit a T helper type 1 (Th1) immune response.
T22 3406-3582 Sentence denotes Moreover, the vaccine should induce the production of a milieu of inflammatory cytokines and lymphokines at the delivery site to elicit a T helper type 1 (Th1) immune response.
T23 3583-3762 Sentence denotes Components of the inflammatory response can be used to target DCs in vivo, activating the so-called danger signal for circumventing the poor immunogenicity of self-tumor antigens.
T23 3583-3762 Sentence denotes Components of the inflammatory response can be used to target DCs in vivo, activating the so-called danger signal for circumventing the poor immunogenicity of self-tumor antigens.
T24 3763-3907 Sentence denotes For example, chemotactic factors of innate immunity are able to deliver Id to APC and render this otherwise non-immunogenic antigen immunogenic.
T24 3763-3907 Sentence denotes For example, chemotactic factors of innate immunity are able to deliver Id to APC and render this otherwise non-immunogenic antigen immunogenic.
T25 3908-4082 Sentence denotes The strategies developed for Id vaccines can be used as a general strategy for eliciting T-cell immunity to other weakly immunogenic, clinically relevant self-tumor antigens.
T25 3908-4082 Sentence denotes The strategies developed for Id vaccines can be used as a general strategy for eliciting T-cell immunity to other weakly immunogenic, clinically relevant self-tumor antigens.