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Id Subject Object Predicate Lexical cue
T1 0-111 Sentence denotes Short-term low-dose corticosteroids vs placebo and nonsteroidal antiinflammatory drugs in rheumatoid arthritis.
T1 0-111 Sentence denotes Short-term low-dose corticosteroids vs placebo and nonsteroidal antiinflammatory drugs in rheumatoid arthritis.
T2 112-123 Sentence denotes BACKGROUND:
T2 112-123 Sentence denotes BACKGROUND:
T3 124-277 Sentence denotes The effectiveness of low dose corticosteroids, equivalent to 15 mg prednisolone daily or less, in patients with rheumatoid arthritis has been questioned.
T3 124-277 Sentence denotes The effectiveness of low dose corticosteroids, equivalent to 15 mg prednisolone daily or less, in patients with rheumatoid arthritis has been questioned.
T4 278-417 Sentence denotes We therefore performed a systematic review of trials which compared corticosteroids with placebo or non-steroidal, anti-inflammatory drugs.
T4 278-417 Sentence denotes We therefore performed a systematic review of trials which compared corticosteroids with placebo or non-steroidal, anti-inflammatory drugs.
T5 418-429 Sentence denotes OBJECTIVES:
T5 418-429 Sentence denotes OBJECTIVES:
T6 430-706 Sentence denotes To determine whether short-term (i.e. as recorded within the first month of therapy), oral low-dose corticosteroids (corresponding to a maximum of 15 mg prednisolone daily) is superior to placebo and non steroidal, antiinflammatory drugs in patients with rheumatoid arthritis.
T6 430-706 Sentence denotes To determine whether short-term (i.e. as recorded within the first month of therapy), oral low-dose corticosteroids (corresponding to a maximum of 15 mg prednisolone daily) is superior to placebo and non steroidal, antiinflammatory drugs in patients with rheumatoid arthritis.
T7 707-723 Sentence denotes SEARCH STRATEGY:
T7 707-723 Sentence denotes SEARCH STRATEGY:
T8 724-827 Sentence denotes Medline Silverplatter, The Cochrane Controlled Trials Register, reference lists and a personal archive.
T8 724-827 Sentence denotes Medline Silverplatter, The Cochrane Controlled Trials Register, reference lists and a personal archive.
T9 828-857 Sentence denotes Date of last search Nov 2001.
T9 828-857 Sentence denotes Date of last search Nov 2001.
T10 858-877 Sentence denotes SELECTION CRITERIA:
T10 858-877 Sentence denotes SELECTION CRITERIA:
T11 878-984 Sentence denotes This review is an update to a previous review which was peer-review and published in the Cochrane Library.
T11 878-984 Sentence denotes This review is an update to a previous review which was peer-review and published in the Cochrane Library.
T12 985-1243 Sentence denotes All randomised studies comparing an oral corticosteroid (not exceeding an equivalent of 15 mg prednisolone daily) with placebo or a non steroidal, antiinflammatory drug were eligible if they reported clinical outcomes within one month after start of therapy.
T12 985-1243 Sentence denotes All randomised studies comparing an oral corticosteroid (not exceeding an equivalent of 15 mg prednisolone daily) with placebo or a non steroidal, antiinflammatory drug were eligible if they reported clinical outcomes within one month after start of therapy.
T13 1244-1273 Sentence denotes DATA COLLECTION AND ANALYSIS:
T13 1244-1273 Sentence denotes DATA COLLECTION AND ANALYSIS:
T14 1274-1401 Sentence denotes Decisions on which trials to include were made independently by two observers based on the methods sections of the trials only.
T14 1274-1401 Sentence denotes Decisions on which trials to include were made independently by two observers based on the methods sections of the trials only.
T15 1402-1545 Sentence denotes Standardised effect measures were used for the statistical analyses; the random effects model was used if P<0.10 for the test of heterogeneity.
T15 1402-1545 Sentence denotes Standardised effect measures were used for the statistical analyses; the random effects model was used if P<0.10 for the test of heterogeneity.
T16 1546-1559 Sentence denotes MAIN RESULTS:
T16 1546-1559 Sentence denotes MAIN RESULTS:
T17 1560-1632 Sentence denotes Ten studies, involving 320 patients, were included in the meta-analysis.
T17 1560-1632 Sentence denotes Ten studies, involving 320 patients, were included in the meta-analysis.
T18 1633-1885 Sentence denotes Prednisolone had a marked effect over placebo on joint tenderness (standardised effect size 1.31, 95% confidence interval 0.78 to 1.83), pain (standardised effect size 1.75, 0.87 to 2.64) and grip strength (standardised effect size 0.41, 0.13 to 0.69).
T18 1633-1885 Sentence denotes Prednisolone had a marked effect over placebo on joint tenderness (standardised effect size 1.31, 95% confidence interval 0.78 to 1.83), pain (standardised effect size 1.75, 0.87 to 2.64) and grip strength (standardised effect size 0.41, 0.13 to 0.69).
T19 1886-2007 Sentence denotes Measured in the original units, the differences were 12 tender joints (6 to 18) and 22 mm Hg (5 to 40) for grip strength.
T19 1886-2007 Sentence denotes Measured in the original units, the differences were 12 tender joints (6 to 18) and 22 mm Hg (5 to 40) for grip strength.
T20 2008-2319 Sentence denotes Prednisolone also had a greater effect than non steroidal, antiinflammatory drugs on joint tenderness (standardised effect size 0.63, 0.11 to 1.16) and pain (standardised effect size 1.25, 0.26 to 2.24), whereas the difference in grip strength was not significant (standardised effect size 0.31, -0.02 to 0.64).
T20 2008-2319 Sentence denotes Prednisolone also had a greater effect than non steroidal, antiinflammatory drugs on joint tenderness (standardised effect size 0.63, 0.11 to 1.16) and pain (standardised effect size 1.25, 0.26 to 2.24), whereas the difference in grip strength was not significant (standardised effect size 0.31, -0.02 to 0.64).
T21 2320-2423 Sentence denotes Measured in the original units, the differences were 9 tender joints (5 to 12) and 12 mm Hg (-6 to 31).
T21 2320-2423 Sentence denotes Measured in the original units, the differences were 9 tender joints (5 to 12) and 12 mm Hg (-6 to 31).
T22 2424-2512 Sentence denotes The risk of adverse effects, also during moderate- and long-term use, seemed acceptable.
T22 2424-2512 Sentence denotes The risk of adverse effects, also during moderate- and long-term use, seemed acceptable.
T23 2513-2536 Sentence denotes REVIEWER'S CONCLUSIONS:
T23 2513-2536 Sentence denotes REVIEWER'S CONCLUSIONS:
T24 2537-2721 Sentence denotes Prednisolone in low doses (not exceeding 15 mg daily) may be used intermittently in patients with rheumatoid arthritis, particularly if the disease cannot be controlled by other means.
T24 2537-2721 Sentence denotes Prednisolone in low doses (not exceeding 15 mg daily) may be used intermittently in patients with rheumatoid arthritis, particularly if the disease cannot be controlled by other means.
T25 2722-2907 Sentence denotes Since prednisolone is highly effective, short-term placebo controlled trials studying the clinical effect of low-dose prednisolone or other oral corticosteroids are no longer necessary.
T25 2722-2907 Sentence denotes Since prednisolone is highly effective, short-term placebo controlled trials studying the clinical effect of low-dose prednisolone or other oral corticosteroids are no longer necessary.