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PubMed:11824946 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-105 Sentence denotes Gelatinase expression and activity in the synovium and skin of patients with erosive psoriatic arthritis.
T1 0-105 Sentence denotes Gelatinase expression and activity in the synovium and skin of patients with erosive psoriatic arthritis.
T2 106-116 Sentence denotes OBJECTIVE:
T2 106-116 Sentence denotes OBJECTIVE:
T3 117-299 Sentence denotes Matrix metalloproteinases (MMP), especially the gelatinases (MMP2, MMP9), have been implicated in several features of inflammatory arthritis including angiogenesis and bone erosions.
T3 117-299 Sentence denotes Matrix metalloproteinases (MMP), especially the gelatinases (MMP2, MMP9), have been implicated in several features of inflammatory arthritis including angiogenesis and bone erosions.
T4 300-496 Sentence denotes We examined the expression and activity of the gelatinases and their regulators in psoriatic skin and synovium using tissue immunohistochemistry and a sensitive tissue based zymographic technique.
T4 300-496 Sentence denotes We examined the expression and activity of the gelatinases and their regulators in psoriatic skin and synovium using tissue immunohistochemistry and a sensitive tissue based zymographic technique.
T5 497-505 Sentence denotes METHODS:
T5 497-505 Sentence denotes METHODS:
T6 506-863 Sentence denotes Lesional and perilesional skin biopsies and synovial samples obtained by closed needle biopsy from 15 patients with erosive psoriatic arthritis (PsA) were analyzed by immunohistochemistry for the expression of the gelatinases and their regulators, tissue inhibitor of metalloproteinase 1 and 2 (TIMP-1, TIMP-2) and membrane type metalloproteinases (MTI-MMP.
T6 506-863 Sentence denotes Lesional and perilesional skin biopsies and synovial samples obtained by closed needle biopsy from 15 patients with erosive psoriatic arthritis (PsA) were analyzed by immunohistochemistry for the expression of the gelatinases and their regulators, tissue inhibitor of metalloproteinase 1 and 2 (TIMP-1, TIMP-2) and membrane type metalloproteinases (MTI-MMP.
T7 864-901 Sentence denotes MT2-MMP), using immunohistochemistry.
T7 864-901 Sentence denotes MT2-MMP), using immunohistochemistry.
T8 902-998 Sentence denotes Synovial tissue from 8 patients with erosive rheumatoid arthritis (RA) was used as a comparison.
T8 902-998 Sentence denotes Synovial tissue from 8 patients with erosive rheumatoid arthritis (RA) was used as a comparison.
T9 999-1071 Sentence denotes MMP tissue expression was quantified by 2 blinded independent observers.
T9 999-1071 Sentence denotes MMP tissue expression was quantified by 2 blinded independent observers.
T10 1072-1205 Sentence denotes Immunohistochemical data are reported as the mean percentage positive cells per total nucleated cells in 10 high power fields +/- SD.
T10 1072-1205 Sentence denotes Immunohistochemical data are reported as the mean percentage positive cells per total nucleated cells in 10 high power fields +/- SD.
T11 1206-1344 Sentence denotes Functional activity of the gelatinases was measured using a sensitive tissue based zymography technique and corrected for protein content.
T11 1206-1344 Sentence denotes Functional activity of the gelatinases was measured using a sensitive tissue based zymography technique and corrected for protein content.
T12 1345-1391 Sentence denotes Zymography data are presented as ng/mg +/- SE.
T12 1345-1391 Sentence denotes Zymography data are presented as ng/mg +/- SE.
T13 1392-1624 Sentence denotes RESULTS: MMP expression was greater in the synovial lining layer (LL) than in the synovial sublining layer (SL) in both PsA and RA tissue for most MMP except collagenase I (MMPI), which was equally distributed between the LL and SL.
T13 1392-1624 Sentence denotes RESULTS: MMP expression was greater in the synovial lining layer (LL) than in the synovial sublining layer (SL) in both PsA and RA tissue for most MMP except collagenase I (MMPI), which was equally distributed between the LL and SL.
T14 1625-1729 Sentence denotes Expression of MMP or their regulators did not differ between PsA synovial membrane (SM) and RA SM in LL.
T14 1625-1729 Sentence denotes Expression of MMP or their regulators did not differ between PsA synovial membrane (SM) and RA SM in LL.
T15 1730-1944 Sentence denotes Moreover, although latent gelatinase A (MMP2) staining in PsA SM was equivalent to RA SM, increased gelatinase A activity was found in PsA SM over RA SM using zymography L82.4 (SD 62.8) vs 10.1 (SD 1.7); p = 0.02].
T15 1730-1944 Sentence denotes Moreover, although latent gelatinase A (MMP2) staining in PsA SM was equivalent to RA SM, increased gelatinase A activity was found in PsA SM over RA SM using zymography L82.4 (SD 62.8) vs 10.1 (SD 1.7); p = 0.02].
T16 1945-2118 Sentence denotes Compared to PsA SM, lesional skin had lower levels of MT1-MMP (MMP14) (1.4 +/- 1.7 vs 15.7 +/- 8.4; p = 0.009) and MT2-MMP (MMP15) (12.1 +/- 8.7 vs 21.6 +/- 9.9; p = 0.001).
T16 1945-2118 Sentence denotes Compared to PsA SM, lesional skin had lower levels of MT1-MMP (MMP14) (1.4 +/- 1.7 vs 15.7 +/- 8.4; p = 0.009) and MT2-MMP (MMP15) (12.1 +/- 8.7 vs 21.6 +/- 9.9; p = 0.001).
T17 2119-2130 Sentence denotes CONCLUSION:
T17 2119-2130 Sentence denotes CONCLUSION:
T18 2131-2339 Sentence denotes We characterized the expression and activity of gelatinases in PsA and demonstrate that gelatinase activity in SM of PsA patients with erosive disease is comparable to if not greater than that in RA synovium.
T18 2131-2339 Sentence denotes We characterized the expression and activity of gelatinases in PsA and demonstrate that gelatinase activity in SM of PsA patients with erosive disease is comparable to if not greater than that in RA synovium.