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PubMed:11283408 JSONTXT 6 Projects

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Id Subject Object Predicate Lexical cue
T1 0-127 Sentence denotes Molecular anatomy of an intracranial aneurysm: coordinated expression of genes involved in wound healing and tissue remodeling.
T1 0-127 Sentence denotes Molecular anatomy of an intracranial aneurysm: coordinated expression of genes involved in wound healing and tissue remodeling.
T2 128-151 Sentence denotes BACKGROUND AND PURPOSE:
T2 128-151 Sentence denotes BACKGROUND AND PURPOSE:
T3 152-228 Sentence denotes Approximately 6% of human beings harbor an unruptured intracranial aneurysm.
T3 152-228 Sentence denotes Approximately 6% of human beings harbor an unruptured intracranial aneurysm.
T4 229-354 Sentence denotes Each year in the United States, >30 000 people suffer a ruptured intracranial aneurysm, resulting in subarachnoid hemorrhage.
T4 229-354 Sentence denotes Each year in the United States, >30 000 people suffer a ruptured intracranial aneurysm, resulting in subarachnoid hemorrhage.
T5 355-662 Sentence denotes Despite the high incidence and catastrophic consequences of a ruptured intracranial aneurysm and the fact that there is considerable evidence that predisposition to intracranial aneurysm has a strong genetic component, very little is understood with regard to the pathology and pathogenesis of this disease.
T5 355-662 Sentence denotes Despite the high incidence and catastrophic consequences of a ruptured intracranial aneurysm and the fact that there is considerable evidence that predisposition to intracranial aneurysm has a strong genetic component, very little is understood with regard to the pathology and pathogenesis of this disease.
T6 663-671 Sentence denotes METHODS:
T6 663-671 Sentence denotes METHODS:
T7 672-974 Sentence denotes To begin characterizing the molecular pathology of intracranial aneurysm, we used a global gene expression analysis approach (SAGE-Lite) in combination with a novel data-mining approach to perform a high-resolution transcript analysis of a single intracranial aneurysm, obtained from a 3-year-old girl.
T7 672-974 Sentence denotes To begin characterizing the molecular pathology of intracranial aneurysm, we used a global gene expression analysis approach (SAGE-Lite) in combination with a novel data-mining approach to perform a high-resolution transcript analysis of a single intracranial aneurysm, obtained from a 3-year-old girl.
T8 975-1067 Sentence denotes RESULTS: SAGE-Lite provides a detailed molecular snapshot of a single intracranial aneurysm.
T8 975-1067 Sentence denotes RESULTS: SAGE-Lite provides a detailed molecular snapshot of a single intracranial aneurysm.
T9 1068-1287 Sentence denotes These data suggest that, at least in this specific case, aneurysmal dilation results in a highly dynamic cellular environment in which extensive wound healing and tissue/extracellular matrix remodeling are taking place.
T9 1068-1287 Sentence denotes These data suggest that, at least in this specific case, aneurysmal dilation results in a highly dynamic cellular environment in which extensive wound healing and tissue/extracellular matrix remodeling are taking place.
T10 1288-1618 Sentence denotes Specifically, we observed significant overexpression of genes encoding extracellular matrix components (eg, COL3A1, COL1A1, COL1A2, COL6A1, COL6A2, elastin) and genes involved in extracellular matrix turnover (TIMP-3, OSF-2), cell adhesion and antiadhesion (SPARC, hevin), cytokinesis (PNUTL2), and cell migration (tetraspanin-5).
T10 1288-1618 Sentence denotes Specifically, we observed significant overexpression of genes encoding extracellular matrix components (eg, COL3A1, COL1A1, COL1A2, COL6A1, COL6A2, elastin) and genes involved in extracellular matrix turnover (TIMP-3, OSF-2), cell adhesion and antiadhesion (SPARC, hevin), cytokinesis (PNUTL2), and cell migration (tetraspanin-5).
T11 1619-1631 Sentence denotes CONCLUSIONS:
T11 1619-1631 Sentence denotes CONCLUSIONS:
T12 1632-1918 Sentence denotes Although these are preliminary data, representing analysis of only one individual, we present a unique first insight into the molecular basis of aneurysmal disease and define numerous candidate markers for future biochemical, physiological, and genetic studies of intracranial aneurysm.
T12 1632-1918 Sentence denotes Although these are preliminary data, representing analysis of only one individual, we present a unique first insight into the molecular basis of aneurysmal disease and define numerous candidate markers for future biochemical, physiological, and genetic studies of intracranial aneurysm.
T13 1919-2000 Sentence denotes Products of these genes will be the focus of future studies in wider sample sets.
T13 1919-2000 Sentence denotes Products of these genes will be the focus of future studies in wider sample sets.