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PubMed:11208990 JSONTXT 19 Projects

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Id Subject Object Predicate Lexical cue
T1 0-92 Sentence denotes Association of nitric oxide production and apoptosis in a model of experimental nephropathy.
T1 0-92 Sentence denotes Association of nitric oxide production and apoptosis in a model of experimental nephropathy.
T2 93-104 Sentence denotes BACKGROUND:
T2 93-104 Sentence denotes BACKGROUND:
T3 105-246 Sentence denotes In recent studies increased amounts of nitric oxide (NO) and apoptosis have been implicated in various pathological conditions in the kidney.
T3 105-246 Sentence denotes In recent studies increased amounts of nitric oxide (NO) and apoptosis have been implicated in various pathological conditions in the kidney.
T4 247-410 Sentence denotes We have studied the role of NO and its association with apoptosis in an experimental model of nephrotic syndrome induced by a single injection of adriamycin (ADR).
T4 247-410 Sentence denotes We have studied the role of NO and its association with apoptosis in an experimental model of nephrotic syndrome induced by a single injection of adriamycin (ADR).
T5 411-419 Sentence denotes METHODS:
T5 411-419 Sentence denotes METHODS:
T6 420-612 Sentence denotes The alteration in the NO pathway was assessed by measuring nitrite levels in serum/urine and by evaluating the changes in vascular reactivity of the isolated perfused rat kidney (IPRK) system.
T6 420-612 Sentence denotes The alteration in the NO pathway was assessed by measuring nitrite levels in serum/urine and by evaluating the changes in vascular reactivity of the isolated perfused rat kidney (IPRK) system.
T7 613-689 Sentence denotes Rats were stratified into control groups and ADR-induced nephropathy groups.
T7 613-689 Sentence denotes Rats were stratified into control groups and ADR-induced nephropathy groups.
T8 690-872 Sentence denotes These two groups were then divided into: group 1, animals receiving saline; and group 2, animals receiving aminoguanidine (AG) which is a specific inhibitor of inducible-NO synthase.
T8 690-872 Sentence denotes These two groups were then divided into: group 1, animals receiving saline; and group 2, animals receiving aminoguanidine (AG) which is a specific inhibitor of inducible-NO synthase.
T9 873-955 Sentence denotes On day 21, rats were sacrificed after obtaining material for biochemical analysis.
T9 873-955 Sentence denotes On day 21, rats were sacrificed after obtaining material for biochemical analysis.
T10 956-964 Sentence denotes RESULTS:
T10 956-964 Sentence denotes RESULTS:
T11 965-1124 Sentence denotes Histopathological examination of the kidneys of rats treated with ADR revealed focal areas of mesangial proliferation and mild tubulointerstitial inflammation.
T11 965-1124 Sentence denotes Histopathological examination of the kidneys of rats treated with ADR revealed focal areas of mesangial proliferation and mild tubulointerstitial inflammation.
T12 1125-1236 Sentence denotes They also had significantly higher levels of proteinuria compared with control and treatment groups (P < 0.05).
T12 1125-1236 Sentence denotes They also had significantly higher levels of proteinuria compared with control and treatment groups (P < 0.05).
T13 1237-1327 Sentence denotes Urine nitrite levels were significantly increased in the ADR-nephropathy group (P < 0.05).
T13 1237-1327 Sentence denotes Urine nitrite levels were significantly increased in the ADR-nephropathy group (P < 0.05).
T14 1328-1447 Sentence denotes In the IPRK phenylephrine and acetylcholine related responses were significantly impaired in the ADR-nephropathy group.
T14 1328-1447 Sentence denotes In the IPRK phenylephrine and acetylcholine related responses were significantly impaired in the ADR-nephropathy group.
T15 1448-1487 Sentence denotes Apoptosis was not detected in controls.
T15 1448-1487 Sentence denotes Apoptosis was not detected in controls.
T16 1488-1600 Sentence denotes However, in the ADR-nephropathy group, numerous apoptotic cells were identified in the tubulointerstitial areas.
T16 1488-1600 Sentence denotes However, in the ADR-nephropathy group, numerous apoptotic cells were identified in the tubulointerstitial areas.
T17 1601-1717 Sentence denotes Double staining revealed numerous interstitial apoptotic cells to stain for ED1, a marker for monocytes/macrophages.
T17 1601-1717 Sentence denotes Double staining revealed numerous interstitial apoptotic cells to stain for ED1, a marker for monocytes/macrophages.
T18 1718-1863 Sentence denotes Treatment with AG prevented the impairment of renal vascular bed responses and reduced both urine nitrite levels and apoptosis to control levels.
T18 1718-1863 Sentence denotes Treatment with AG prevented the impairment of renal vascular bed responses and reduced both urine nitrite levels and apoptosis to control levels.
T19 1864-1875 Sentence denotes CONCLUSION:
T19 1864-1875 Sentence denotes CONCLUSION:
T20 1876-1993 Sentence denotes We suggest that interactions between NO and apoptosis are important in the pathogenesis of the ADR-induced nephrosis.
T20 1876-1993 Sentence denotes We suggest that interactions between NO and apoptosis are important in the pathogenesis of the ADR-induced nephrosis.