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Id Subject Object Predicate Lexical cue
T1 0-98 Sentence denotes Significance of endothelial prostacyclin and nitric oxide in peripheral and pulmonary circulation.
T1 0-98 Sentence denotes Significance of endothelial prostacyclin and nitric oxide in peripheral and pulmonary circulation.
T2 99-110 Sentence denotes BACKGROUND:
T2 99-110 Sentence denotes BACKGROUND:
T3 111-337 Sentence denotes Vasoprotective function of endothelial cells is associated, among others, with biosynthesis and release of nitric oxide (NO), prostacyclin (PGI2), prostaglandin E2 (PGE2), carbon monoxide (CO) and plasminogen activator (t-PA).
T3 111-337 Sentence denotes Vasoprotective function of endothelial cells is associated, among others, with biosynthesis and release of nitric oxide (NO), prostacyclin (PGI2), prostaglandin E2 (PGE2), carbon monoxide (CO) and plasminogen activator (t-PA).
T4 338-592 Sentence denotes These endothelial mediators calm down activated platelets and leukocytes, prevent the occurrence of parietal thrombotic events, promote thrombolysis, maintain tissue perfusion and protect vascular wall against acute damage and against chronic remodeling.
T4 338-592 Sentence denotes These endothelial mediators calm down activated platelets and leukocytes, prevent the occurrence of parietal thrombotic events, promote thrombolysis, maintain tissue perfusion and protect vascular wall against acute damage and against chronic remodeling.
T5 593-924 Sentence denotes Endothelial dysfunction in patients suffering from atherosclerosis or diabetes type 2 is associated not only with suppression in release of the above mediators but also with deleterious discharge of prostaglandin endoperoxides (PGH2, PGG2), superoxide anion (O2-, peroxynitrite (ONOO-), and plasminogen activator inhibitor (PAI-1).
T5 593-924 Sentence denotes Endothelial dysfunction in patients suffering from atherosclerosis or diabetes type 2 is associated not only with suppression in release of the above mediators but also with deleterious discharge of prostaglandin endoperoxides (PGH2, PGG2), superoxide anion (O2-, peroxynitrite (ONOO-), and plasminogen activator inhibitor (PAI-1).
T6 925-1073 Sentence denotes We looked for mechanisms of protective endothelial function, with a special respect to the differences between peripheral and pulmonary circulation.
T6 925-1073 Sentence denotes We looked for mechanisms of protective endothelial function, with a special respect to the differences between peripheral and pulmonary circulation.
T7 1074-1082 Sentence denotes METHODS:
T7 1074-1082 Sentence denotes METHODS:
T8 1083-1244 Sentence denotes Cultured endothelial cells of bovine aorta (BAEC) were used to study physiological and pharmacological mechanisms of increasing free cytoplasmic calcium [Ca2+]i.
T8 1083-1244 Sentence denotes Cultured endothelial cells of bovine aorta (BAEC) were used to study physiological and pharmacological mechanisms of increasing free cytoplasmic calcium [Ca2+]i.
T9 1245-1305 Sentence denotes A porphyrinic sensor quantified the release of NO from BAEC.
T9 1245-1305 Sentence denotes A porphyrinic sensor quantified the release of NO from BAEC.
T10 1306-1441 Sentence denotes In cultured human umbilical vein endothelial cells (HUVEC) we looked for induction by bradykinin (Bk) of mRNAs for a number of enzymes.
T10 1306-1441 Sentence denotes In cultured human umbilical vein endothelial cells (HUVEC) we looked for induction by bradykinin (Bk) of mRNAs for a number of enzymes.
T11 1442-1721 Sentence denotes In blood perfused rat lungs we studied protective role of NO against injury inferred by lipopolysaccharide on pulmonary microcirculation that was accomplished by thromboxane A2 (TXA2), platelet activating factor (PAF), cysteinyl-leukotrienes (cyst-LTs) and the complement system.
T11 1442-1721 Sentence denotes In blood perfused rat lungs we studied protective role of NO against injury inferred by lipopolysaccharide on pulmonary microcirculation that was accomplished by thromboxane A2 (TXA2), platelet activating factor (PAF), cysteinyl-leukotrienes (cyst-LTs) and the complement system.
T12 1722-1999 Sentence denotes In vivo we analyzed the influence of Bk, perindopril and quinapril ('tissue type' angiotensin converting enzyme inhibitors, ACE-Is) on endothelial function in entire circulation of anaesthetized rats using a thrombolytic bioassay and EIA for 6-keto-PGF1 alpha and t-PA antigen.
T12 1722-1999 Sentence denotes In vivo we analyzed the influence of Bk, perindopril and quinapril ('tissue type' angiotensin converting enzyme inhibitors, ACE-Is) on endothelial function in entire circulation of anaesthetized rats using a thrombolytic bioassay and EIA for 6-keto-PGF1 alpha and t-PA antigen.
T13 2000-2008 Sentence denotes RESULTS:
T13 2000-2008 Sentence denotes RESULTS:
T14 2009-2181 Sentence denotes In BAEC Bk via kinin B2 receptors raised in a concentration-dependent manner (1 pM-10 nM) free cytoplasmic calcium ions [Ca2+]i, that triggered the release of NO from BAEC.
T14 2009-2181 Sentence denotes In BAEC Bk via kinin B2 receptors raised in a concentration-dependent manner (1 pM-10 nM) free cytoplasmic calcium ions [Ca2+]i, that triggered the release of NO from BAEC.
T15 2182-2552 Sentence denotes Calcium ionophore (A23187, 1-100 nM) as well as receptor agonists such as adenosine diphosphate (ADP, 10 nM-1 microM), adrenaline (Adr, 1-10 microM) or acetylcholine (Ach, 10-100 microM) produced a similar rise in endothelial [Ca2+]i as did Bk at a nanomolar concentration. 'Tissue type' ACE-Is, e.g. quinapril or perindopril acted through accumulation of endogenous Bk.
T15 2182-2552 Sentence denotes Calcium ionophore (A23187, 1-100 nM) as well as receptor agonists such as adenosine diphosphate (ADP, 10 nM-1 microM), adrenaline (Adr, 1-10 microM) or acetylcholine (Ach, 10-100 microM) produced a similar rise in endothelial [Ca2+]i as did Bk at a nanomolar concentration. 'Tissue type' ACE-Is, e.g. quinapril or perindopril acted through accumulation of endogenous Bk.
T16 2553-2681 Sentence denotes However, the potency of ACE-I to change endothelial function is by several orders of magnitude lower than that for exogenous Bk.
T16 2553-2681 Sentence denotes However, the potency of ACE-I to change endothelial function is by several orders of magnitude lower than that for exogenous Bk.
T17 2682-2903 Sentence denotes In vivo the major difference between thrombolytic actions by quinapril or perindopril on one hand, and by exogenous Bk on the other was longevity of thrombolysis by ACE I and a distinct hypotensive action of exogenous Bk.
T17 2682-2903 Sentence denotes In vivo the major difference between thrombolytic actions by quinapril or perindopril on one hand, and by exogenous Bk on the other was longevity of thrombolysis by ACE I and a distinct hypotensive action of exogenous Bk.
T18 2904-3088 Sentence denotes Still, the long-lasting isolated thrombolytic effect of ACE I was mediated entirely by endogenous BK as evidenced by the preventive action of icatibant, a kinin B2 receptor antagonist.
T18 2904-3088 Sentence denotes Still, the long-lasting isolated thrombolytic effect of ACE I was mediated entirely by endogenous BK as evidenced by the preventive action of icatibant, a kinin B2 receptor antagonist.
T19 3089-3294 Sentence denotes Moreover, in vivo the immediate thrombolysis by ACE-I was mediated by PGI2 rather than by NO or t-PA, as shown by pharmacological analysis, and by direct blood assays of 6-keto-PGF1 alpha and t-PA antigen.
T19 3089-3294 Sentence denotes Moreover, in vivo the immediate thrombolysis by ACE-I was mediated by PGI2 rather than by NO or t-PA, as shown by pharmacological analysis, and by direct blood assays of 6-keto-PGF1 alpha and t-PA antigen.
T20 3295-3497 Sentence denotes Bradykinin as a mediator of pleiotropic endothelial action of several cardiovascular drugs (e.g. ACE-I) may complete its mission not only through B2 receptor and [Ca2+]i--mediated release of PGI2 or NO.
T20 3295-3497 Sentence denotes Bradykinin as a mediator of pleiotropic endothelial action of several cardiovascular drugs (e.g. ACE-I) may complete its mission not only through B2 receptor and [Ca2+]i--mediated release of PGI2 or NO.
T21 3498-3545 Sentence denotes Here, we describe a new route of the Bk action.
T21 3498-3545 Sentence denotes Here, we describe a new route of the Bk action.
T22 3546-3687 Sentence denotes Bk mediated induction of the [Ca2+]i-independent, so called 'inducible', endothelial isoenzymes required for generation of CO, PGI2 and PGE2.
T22 3546-3687 Sentence denotes Bk mediated induction of the [Ca2+]i-independent, so called 'inducible', endothelial isoenzymes required for generation of CO, PGI2 and PGE2.
T23 3688-3915 Sentence denotes After 4 hours of incubation of HUVEC with Bk (10 nM) it induced mRNAs for haemooxygenase 1 (HO-1), cyclooxygenase 2 (COX-2), prostaglandin E synthase (PGE-S) whereas mRNA for nitric oxide synthase 2 (NOS-2) was weakly affected.
T23 3688-3915 Sentence denotes After 4 hours of incubation of HUVEC with Bk (10 nM) it induced mRNAs for haemooxygenase 1 (HO-1), cyclooxygenase 2 (COX-2), prostaglandin E synthase (PGE-S) whereas mRNA for nitric oxide synthase 2 (NOS-2) was weakly affected.
T24 3916-4045 Sentence denotes We proved also that unlike in peripheral circulation, in pulmonary circulation only NO but not PGI2 would play a protective role.
T24 3916-4045 Sentence denotes We proved also that unlike in peripheral circulation, in pulmonary circulation only NO but not PGI2 would play a protective role.
T25 4046-4136 Sentence denotes In the blood-perfused lung, endotoxaemia liberates lipids, such as TXA2, PAF and cyst-LTs.
T25 4046-4136 Sentence denotes In the blood-perfused lung, endotoxaemia liberates lipids, such as TXA2, PAF and cyst-LTs.
T26 4137-4217 Sentence denotes These toxic lipids along with the activated complement mediate pulmonary damage.
T26 4137-4217 Sentence denotes These toxic lipids along with the activated complement mediate pulmonary damage.
T27 4218-4357 Sentence denotes Pulmonary endothelial nitric oxide is the only local protector against lung injury evoked by the phagocytised bacterial lipopolysaccharide.
T27 4218-4357 Sentence denotes Pulmonary endothelial nitric oxide is the only local protector against lung injury evoked by the phagocytised bacterial lipopolysaccharide.
T28 4358-4366 Sentence denotes SUMMARY:
T28 4358-4366 Sentence denotes SUMMARY:
T29 4367-4486 Sentence denotes Summing up, in peripheral circulation endogenous Bk is the most efficient activator of protective endothelial function.
T29 4367-4486 Sentence denotes Summing up, in peripheral circulation endogenous Bk is the most efficient activator of protective endothelial function.
T30 4487-4576 Sentence denotes For instance, thrombolytic action of 'tissue type' ACE-I depends on the Bk-released PGI2.
T30 4487-4576 Sentence denotes For instance, thrombolytic action of 'tissue type' ACE-I depends on the Bk-released PGI2.
T31 4577-4710 Sentence denotes Acting as an agonist of endothelial B2 kinin receptors Bk rises [Ca2+]i with a subsequent activation of constitutive COX 1 and NOS-3.
T31 4577-4710 Sentence denotes Acting as an agonist of endothelial B2 kinin receptors Bk rises [Ca2+]i with a subsequent activation of constitutive COX 1 and NOS-3.
T32 4711-4767 Sentence denotes This is followed by an immediate release of PGI2 and NO.
T32 4711-4767 Sentence denotes This is followed by an immediate release of PGI2 and NO.
T33 4768-4956 Sentence denotes Moreover, acting as 'microcytokine' Bk induces mRNAs for HO-1, COX-2 and PGE S, the isoenzymes responsible for a delayed endothelial biosynthesis of CO, PGI2 and PGE2. (ABSTRACT TRUNCATED)
T33 4768-4956 Sentence denotes Moreover, acting as 'microcytokine' Bk induces mRNAs for HO-1, COX-2 and PGE S, the isoenzymes responsible for a delayed endothelial biosynthesis of CO, PGI2 and PGE2. (ABSTRACT TRUNCATED)