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PubMed:10840460 JSONTXT 21 Projects

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Id Subject Object Predicate Lexical cue
T1 0-119 Sentence denotes Cyclophosphamide-induced cystitis in freely-moving conscious rats: behavioral approach to a new model of visceral pain.
T1 0-119 Sentence denotes Cyclophosphamide-induced cystitis in freely-moving conscious rats: behavioral approach to a new model of visceral pain.
T2 120-128 Sentence denotes PURPOSE:
T2 120-128 Sentence denotes PURPOSE:
T3 129-201 Sentence denotes To develop a model of visceral pain in rats using a behavioral approach.
T3 129-201 Sentence denotes To develop a model of visceral pain in rats using a behavioral approach.
T4 202-369 Sentence denotes Cyclophosphamide (CP), an antitumoral agent known to produce toxic effects on the bladder wall through its main toxic metabolite acrolein, was used to induce cystitis.
T4 202-369 Sentence denotes Cyclophosphamide (CP), an antitumoral agent known to produce toxic effects on the bladder wall through its main toxic metabolite acrolein, was used to induce cystitis.
T5 370-507 Sentence denotes MATERIALS AND METHODS: CP was administered at doses of 50, 100 and 200 mg./kg. i.p. to male rats, and their behavior observed and scored.
T5 370-507 Sentence denotes MATERIALS AND METHODS: CP was administered at doses of 50, 100 and 200 mg./kg. i.p. to male rats, and their behavior observed and scored.
T6 508-662 Sentence denotes The effects of morphine (0.5 to 4 mg./kg. i.v.) on CP-induced behavioral modifications were tested administered alone and after naloxone (1 mg./kg. s.c.).
T6 508-662 Sentence denotes The effects of morphine (0.5 to 4 mg./kg. i.v.) on CP-induced behavioral modifications were tested administered alone and after naloxone (1 mg./kg. s.c.).
T7 663-825 Sentence denotes In addition, 90 minutes after CP injection, that is, at the time of administration of morphine, the bladder was removed in some rats for histological examination.
T7 663-825 Sentence denotes In addition, 90 minutes after CP injection, that is, at the time of administration of morphine, the bladder was removed in some rats for histological examination.
T8 826-1097 Sentence denotes Finally, to show that the bladder is essential for the CP-induced behavioral modifications, female rats also received CP at doses of 200 mg./kg. i.p. and of 20 mg. by the intravesical route, and acrolein at doses of 0.5 mg. by the intravesical route and of 5 mg./kg. i.v.
T8 826-1097 Sentence denotes Finally, to show that the bladder is essential for the CP-induced behavioral modifications, female rats also received CP at doses of 200 mg./kg. i.p. and of 20 mg. by the intravesical route, and acrolein at doses of 0.5 mg. by the intravesical route and of 5 mg./kg. i.v.
T9 1098-1260 Sentence denotes RESULTS: CP dose-relatedly induced marked behavioral modifications in male rats: breathing rate decrease, closing of the eyes and occurrence of specific postures.
T9 1098-1260 Sentence denotes RESULTS: CP dose-relatedly induced marked behavioral modifications in male rats: breathing rate decrease, closing of the eyes and occurrence of specific postures.
T10 1261-1323 Sentence denotes Morphine dose-dependently reversed these behavioral disorders.
T10 1261-1323 Sentence denotes Morphine dose-dependently reversed these behavioral disorders.
T11 1324-1430 Sentence denotes A dose of 0.5 mg./kg. produced a reduction of almost 50% of the behavioral score induced by CP 200 mg./kg.
T11 1324-1430 Sentence denotes A dose of 0.5 mg./kg. produced a reduction of almost 50% of the behavioral score induced by CP 200 mg./kg.
T12 1431-1498 Sentence denotes This effect was completely prevented by pretreatment with naloxone.
T12 1431-1498 Sentence denotes This effect was completely prevented by pretreatment with naloxone.
T13 1499-1646 Sentence denotes At the time of administration of morphine, histological modifications of the bladder wall, such as chorionic and muscle layer edema, were observed.
T13 1499-1646 Sentence denotes At the time of administration of morphine, histological modifications of the bladder wall, such as chorionic and muscle layer edema, were observed.
T14 1647-1764 Sentence denotes In female rats, CP 200 mg./kg. i.p. produced the same marked behavioral modifications as those observed in male rats.
T14 1647-1764 Sentence denotes In female rats, CP 200 mg./kg. i.p. produced the same marked behavioral modifications as those observed in male rats.
T15 1765-2010 Sentence denotes Administered at the dose of 20 mg. intravesically, CP did not produce any behavioral effects, whereas acrolein at 0.5 mg. intravesically induced behavioral modifications identical to those under CP 200 mg./kg. i.p., with the same maximal levels.
T15 1765-2010 Sentence denotes Administered at the dose of 20 mg. intravesically, CP did not produce any behavioral effects, whereas acrolein at 0.5 mg. intravesically induced behavioral modifications identical to those under CP 200 mg./kg. i.p., with the same maximal levels.
T16 2011-2093 Sentence denotes Conversely, acrolein 5 mg./kg. i.v. did not produce any behavioral effects at all.
T16 2011-2093 Sentence denotes Conversely, acrolein 5 mg./kg. i.v. did not produce any behavioral effects at all.
T17 2094-2106 Sentence denotes CONCLUSIONS:
T17 2094-2106 Sentence denotes CONCLUSIONS:
T18 2107-2371 Sentence denotes Overall, these results indicate that this experimental model of CP-induced cystitis may be an interesting new behavioral model of inflammatory visceral pain, allowing a better understanding of these painful syndromes and thus a better therapeutic approach to them.
T18 2107-2371 Sentence denotes Overall, these results indicate that this experimental model of CP-induced cystitis may be an interesting new behavioral model of inflammatory visceral pain, allowing a better understanding of these painful syndromes and thus a better therapeutic approach to them.