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PubMed:10818206 JSONTXT 10 Projects

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Id Subject Object Predicate Lexical cue
T1 0-138 Sentence denotes Isolation, genomic organization, and expression analysis of the mouse and rat homologs of MEFV, the gene for familial mediterranean fever.
T1 0-138 Sentence denotes Isolation, genomic organization, and expression analysis of the mouse and rat homologs of MEFV, the gene for familial mediterranean fever.
T2 139-261 Sentence denotes Familial Mediterranean fever (FMF) is a recessive disorder characterized by episodes of fever with serositis or synovitis.
T2 139-261 Sentence denotes Familial Mediterranean fever (FMF) is a recessive disorder characterized by episodes of fever with serositis or synovitis.
T3 262-396 Sentence denotes Recently the FMF gene (MEFV) was cloned; the protein product, pyrin/marenostrin, is thought to regulate inflammation in myeloid cells.
T3 262-396 Sentence denotes Recently the FMF gene (MEFV) was cloned; the protein product, pyrin/marenostrin, is thought to regulate inflammation in myeloid cells.
T4 397-461 Sentence denotes In this manuscript we report the mouse and rat homologs of MEFV.
T4 397-461 Sentence denotes In this manuscript we report the mouse and rat homologs of MEFV.
T5 462-603 Sentence denotes The murine gene contains ten exons with a coding sequence of 2304 bp, while the rat homolog has nine exons with a coding sequence of 2253 bp.
T5 462-603 Sentence denotes The murine gene contains ten exons with a coding sequence of 2304 bp, while the rat homolog has nine exons with a coding sequence of 2253 bp.
T6 604-801 Sentence denotes A considerable amino acid sequence homology was observed between the mouse and human (47.6% identity and 65.5% similarity) and between the mouse and rat genes (73.5% identity and 82.1% similarity).
T6 604-801 Sentence denotes A considerable amino acid sequence homology was observed between the mouse and human (47.6% identity and 65.5% similarity) and between the mouse and rat genes (73.5% identity and 82.1% similarity).
T7 802-1004 Sentence denotes The predicted rodent proteins have several important domains and signals found in human pyrin, including a B-box zinc finger domain, Robbins-Dingwall nuclear localization signal, and coiled-coil domain.
T7 802-1004 Sentence denotes The predicted rodent proteins have several important domains and signals found in human pyrin, including a B-box zinc finger domain, Robbins-Dingwall nuclear localization signal, and coiled-coil domain.
T8 1005-1212 Sentence denotes However, perhaps because of an ancient frame-shift mutation, neither the mouse nor the rat protein has an intact C-terminal B30.2 domain, in which most FMF-associated mutations have been found in human MEFV.
T8 1005-1212 Sentence denotes However, perhaps because of an ancient frame-shift mutation, neither the mouse nor the rat protein has an intact C-terminal B30.2 domain, in which most FMF-associated mutations have been found in human MEFV.
T9 1213-1325 Sentence denotes Nevertheless, like the human gene, mouse Mefv is expressed in peripheral blood granulocytes but not lymphocytes.
T9 1213-1325 Sentence denotes Nevertheless, like the human gene, mouse Mefv is expressed in peripheral blood granulocytes but not lymphocytes.
T10 1326-1477 Sentence denotes Consistent with its expression in granulocytes, Mefv was detected at high levels in the primary follicles and marginal zones of the splenic white pulp.
T10 1326-1477 Sentence denotes Consistent with its expression in granulocytes, Mefv was detected at high levels in the primary follicles and marginal zones of the splenic white pulp.
T11 1478-1593 Sentence denotes Mefv is localized on mouse Chromosome (Chr) 16, region A3-B1, extending a region of synteny with human Chr 16p13.3.
T11 1478-1593 Sentence denotes Mefv is localized on mouse Chromosome (Chr) 16, region A3-B1, extending a region of synteny with human Chr 16p13.3.
T12 1594-1715 Sentence denotes Development of knockout and knockin mouse models may provide further insights into the functional evolution of this gene.
T12 1594-1715 Sentence denotes Development of knockout and knockin mouse models may provide further insights into the functional evolution of this gene.