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PubMed:10807793 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-148 Sentence denotes The gene for familial Mediterranean fever, MEFV, is expressed in early leukocyte development and is regulated in response to inflammatory mediators.
T1 0-148 Sentence denotes The gene for familial Mediterranean fever, MEFV, is expressed in early leukocyte development and is regulated in response to inflammatory mediators.
T2 149-288 Sentence denotes Familial Mediterranean fever (FMF) is a recessive disorder characterized by episodes of fever and neutrophil-mediated serosal inflammation.
T2 149-288 Sentence denotes Familial Mediterranean fever (FMF) is a recessive disorder characterized by episodes of fever and neutrophil-mediated serosal inflammation.
T3 289-461 Sentence denotes We recently identified the gene causing FMF, designated MEFV, and found it to be expressed in mature neutrophils, suggesting that it functions as an inflammatory regulator.
T3 289-461 Sentence denotes We recently identified the gene causing FMF, designated MEFV, and found it to be expressed in mature neutrophils, suggesting that it functions as an inflammatory regulator.
T4 462-559 Sentence denotes To facilitate our understanding of the normal function of MEFV, we extended our previous studies.
T4 462-559 Sentence denotes To facilitate our understanding of the normal function of MEFV, we extended our previous studies.
T5 560-745 Sentence denotes MEFV messenger RNA was detected by reverse transcriptase-polymerase chain reaction in bone marrow leukocytes, with differential expression observed among cells by in situ hybridization.
T5 560-745 Sentence denotes MEFV messenger RNA was detected by reverse transcriptase-polymerase chain reaction in bone marrow leukocytes, with differential expression observed among cells by in situ hybridization.
T6 746-900 Sentence denotes CD34 hematopoietic stem-cell cultures induced toward the granulocytic lineage expressed MEFV at the myelocyte stage, concurrently with lineage commitment.
T6 746-900 Sentence denotes CD34 hematopoietic stem-cell cultures induced toward the granulocytic lineage expressed MEFV at the myelocyte stage, concurrently with lineage commitment.
T7 901-1003 Sentence denotes The prepromyelocytic cell line HL60 expressed MEFV only at granulocytic and monocytic differentiation.
T7 901-1003 Sentence denotes The prepromyelocytic cell line HL60 expressed MEFV only at granulocytic and monocytic differentiation.
T8 1004-1071 Sentence denotes MEFV was also expressed in the monocytic cell lines U937 and THP-1.
T8 1004-1071 Sentence denotes MEFV was also expressed in the monocytic cell lines U937 and THP-1.
T9 1072-1199 Sentence denotes Among peripheral blood leukocytes, MEFV expression was detected in neutrophils, eosinophils, and to varying degrees, monocytes.
T9 1072-1199 Sentence denotes Among peripheral blood leukocytes, MEFV expression was detected in neutrophils, eosinophils, and to varying degrees, monocytes.
T10 1200-1435 Sentence denotes Consistent with the tissue specificity of expression, complete sequencing and analysis of upstream regulatory regions of MEFV revealed homology to myeloid-specific promoters and to more broadly expressed inflammatory promoter elements.
T10 1200-1435 Sentence denotes Consistent with the tissue specificity of expression, complete sequencing and analysis of upstream regulatory regions of MEFV revealed homology to myeloid-specific promoters and to more broadly expressed inflammatory promoter elements.
T11 1436-1725 Sentence denotes In vitro stimulation of monocytes with the proinflammatory agents interferon (IFN) gamma, tumor necrosis factor, and lipopolysaccharide induced MEFV expression, whereas the antiinflammatory cytokines interleukin (IL) 4, IL-10, and transforming growth factor beta inhibited such expression.
T11 1436-1725 Sentence denotes In vitro stimulation of monocytes with the proinflammatory agents interferon (IFN) gamma, tumor necrosis factor, and lipopolysaccharide induced MEFV expression, whereas the antiinflammatory cytokines interleukin (IL) 4, IL-10, and transforming growth factor beta inhibited such expression.
T12 1726-1801 Sentence denotes Induction by IFN-gamma occurred rapidly and was resistant to cycloheximide.
T12 1726-1801 Sentence denotes Induction by IFN-gamma occurred rapidly and was resistant to cycloheximide.
T13 1802-1841 Sentence denotes IFN-alpha also induced MEFV expression.
T13 1802-1841 Sentence denotes IFN-alpha also induced MEFV expression.
T14 1842-1942 Sentence denotes In granulocytes, MEFV was up-regulated by IFN-gamma and the combination of IFN-alpha and colchicine.
T14 1842-1942 Sentence denotes In granulocytes, MEFV was up-regulated by IFN-gamma and the combination of IFN-alpha and colchicine.
T15 1943-2117 Sentence denotes These results refine understanding of MEFV by placing the gene in the myelomonocytic-specific proinflammatory pathway and identifying it as an IFN-gamma immediate early gene.
T15 1943-2117 Sentence denotes These results refine understanding of MEFV by placing the gene in the myelomonocytic-specific proinflammatory pathway and identifying it as an IFN-gamma immediate early gene.