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PubMed:10477716 JSONTXT 11 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-200 Sentence denotes Nuclear factor-kappaB-dependent induction of interleukin-8 gene expression by tumor necrosis factor alpha: evidence for an antioxidant sensitive activating pathway distinct from nuclear translocation.
T1 0-200 Sentence denotes Nuclear factor-kappaB-dependent induction of interleukin-8 gene expression by tumor necrosis factor alpha: evidence for an antioxidant sensitive activating pathway distinct from nuclear translocation.
T2 201-330 Sentence denotes Tumor necrosis factor alpha (TNFalpha) is a pluripotent activator of inflammation by inducing a proinflammatory cytokine cascade.
T2 201-330 Sentence denotes Tumor necrosis factor alpha (TNFalpha) is a pluripotent activator of inflammation by inducing a proinflammatory cytokine cascade.
T3 331-441 Sentence denotes This phenomenon is mediated, in part, through inducible expression of the CXC chemokine, interleukin-8 (IL-8).
T3 331-441 Sentence denotes This phenomenon is mediated, in part, through inducible expression of the CXC chemokine, interleukin-8 (IL-8).
T4 442-603 Sentence denotes In this study, we investigate the role of TNFalpha-inducible reactive oxygen species (ROS) in IL-8 expression by "monocyte-like" U937 histiocytic lymphoma cells.
T4 442-603 Sentence denotes In this study, we investigate the role of TNFalpha-inducible reactive oxygen species (ROS) in IL-8 expression by "monocyte-like" U937 histiocytic lymphoma cells.
T5 604-732 Sentence denotes TNFalpha is a rapid activator of IL-8 gene expression by U937, producing a 50-fold induction of mRNA within 1 hour of treatment.
T5 604-732 Sentence denotes TNFalpha is a rapid activator of IL-8 gene expression by U937, producing a 50-fold induction of mRNA within 1 hour of treatment.
T6 733-899 Sentence denotes In gene transfection assays, the effect of TNFalpha requires the presence of an inducible nuclear factor-kappaB (NF-kappaB) (Rel A) binding site in the IL-8 promoter.
T6 733-899 Sentence denotes In gene transfection assays, the effect of TNFalpha requires the presence of an inducible nuclear factor-kappaB (NF-kappaB) (Rel A) binding site in the IL-8 promoter.
T7 900-1086 Sentence denotes TNFalpha treatment induces a rapid translocation of the 65 kD transcriptional activator NF-kappaB subunit, Rel A, whose binding in the nucleus occurs before changes in intracellular ROS.
T7 900-1086 Sentence denotes TNFalpha treatment induces a rapid translocation of the 65 kD transcriptional activator NF-kappaB subunit, Rel A, whose binding in the nucleus occurs before changes in intracellular ROS.
T8 1087-1267 Sentence denotes Pretreatment (or up to 15 minutes posttreatment) relative to TNFalpha with the antioxidant dimethyl sulfoxide (DMSO) (2% [vol/vol]) blocks 80% of NF-kappaB-dependent transcription.
T8 1087-1267 Sentence denotes Pretreatment (or up to 15 minutes posttreatment) relative to TNFalpha with the antioxidant dimethyl sulfoxide (DMSO) (2% [vol/vol]) blocks 80% of NF-kappaB-dependent transcription.
T9 1268-1337 Sentence denotes Surprisingly, however, DMSO has no effect on inducible Rel A binding.
T9 1268-1337 Sentence denotes Surprisingly, however, DMSO has no effect on inducible Rel A binding.
T10 1338-1470 Sentence denotes Similar selective effects on NF-kappaB transcription are seen with the unrelated antioxidants, N-acetylcysteine (NAC) and vitamin C.
T10 1338-1470 Sentence denotes Similar selective effects on NF-kappaB transcription are seen with the unrelated antioxidants, N-acetylcysteine (NAC) and vitamin C.
T11 1471-1680 Sentence denotes These data indicate that TNFalpha induces a delayed ROS-dependent signalling pathway that is required for NF-kappaB transcriptional activation and is separable from that required for its nuclear translocation.
T11 1471-1680 Sentence denotes These data indicate that TNFalpha induces a delayed ROS-dependent signalling pathway that is required for NF-kappaB transcriptional activation and is separable from that required for its nuclear translocation.
T12 1681-1791 Sentence denotes Further definition of this pathway will yield new insights into inflammation initiated by TNFalpha signalling.
T12 1681-1791 Sentence denotes Further definition of this pathway will yield new insights into inflammation initiated by TNFalpha signalling.