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PubMed:10455128 JSONTXT 31 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-143 Sentence denotes Differential effects of lipopolysaccharide and tumor necrosis factor on monocytic IkappaB kinase signalsome activation and IkappaB proteolysis.
T1 0-143 Sentence denotes Differential effects of lipopolysaccharide and tumor necrosis factor on monocytic IkappaB kinase signalsome activation and IkappaB proteolysis.
T2 144-263 Sentence denotes The inflammatory mediators lipopolysaccharide (LPS) and tumor necrosis factor (TNF) are potent activators of NF-kappaB.
T2 144-263 Sentence denotes The inflammatory mediators lipopolysaccharide (LPS) and tumor necrosis factor (TNF) are potent activators of NF-kappaB.
T3 264-619 Sentence denotes This study compared the effect of these stimuli on endogenous IkappaB kinase (IKK) signalsome activation and IkappaB phosphorylation/proteolysis in human monocytic cells and investigated the role of the signalsome proteins IKK-alpha, IKK-beta, NF-kappaB-inducing kinase (NIK), IKK-gamma (NF-kappaB essential modulator), and IKK complex-associated protein.
T3 264-619 Sentence denotes This study compared the effect of these stimuli on endogenous IkappaB kinase (IKK) signalsome activation and IkappaB phosphorylation/proteolysis in human monocytic cells and investigated the role of the signalsome proteins IKK-alpha, IKK-beta, NF-kappaB-inducing kinase (NIK), IKK-gamma (NF-kappaB essential modulator), and IKK complex-associated protein.
T4 620-786 Sentence denotes Kinase assays showed that TNF elicited a rapid but short-lived induction of IKK activity with a 3-fold greater effect on IKK-alpha than on IKK-beta, peaking at 5 min.
T4 620-786 Sentence denotes Kinase assays showed that TNF elicited a rapid but short-lived induction of IKK activity with a 3-fold greater effect on IKK-alpha than on IKK-beta, peaking at 5 min.
T5 787-890 Sentence denotes In contrast, LPS predominantly stimulated IKK-beta activity, which slowly increased, peaking at 30 min.
T5 787-890 Sentence denotes In contrast, LPS predominantly stimulated IKK-beta activity, which slowly increased, peaking at 30 min.
T6 891-1020 Sentence denotes A second peak was observed at a later time point following LPS stimulation, which consisted of both IKK-alpha and -beta activity.
T6 891-1020 Sentence denotes A second peak was observed at a later time point following LPS stimulation, which consisted of both IKK-alpha and -beta activity.
T7 1021-1103 Sentence denotes The endogenous levels of the signalsome components were unaffected by stimulation.
T7 1021-1103 Sentence denotes The endogenous levels of the signalsome components were unaffected by stimulation.
T8 1104-1241 Sentence denotes Furthermore, our studies showed association of the IKK-alpha/beta heterodimer with NIK, IkappaB-alpha and -epsilon in unstimulated cells.
T8 1104-1241 Sentence denotes Furthermore, our studies showed association of the IKK-alpha/beta heterodimer with NIK, IkappaB-alpha and -epsilon in unstimulated cells.
T9 1242-1451 Sentence denotes Exposure to LPS or TNF led to differential patterns of IkappaB-alpha and IkappaB-epsilon disappearance from and reassembly with the signalsome, whereas IKK-alpha, IKK-beta, and NIK remained complex-associated.
T9 1242-1451 Sentence denotes Exposure to LPS or TNF led to differential patterns of IkappaB-alpha and IkappaB-epsilon disappearance from and reassembly with the signalsome, whereas IKK-alpha, IKK-beta, and NIK remained complex-associated.
T10 1452-1683 Sentence denotes NIK cannot phosphorylate IkappaB-alpha directly, but it appears to be a functionally important subunit, because mutated NIK inhibited stimulus-induced kappaB-dependent transcription more effectively than mutated IKK-alpha or -beta.
T10 1452-1683 Sentence denotes NIK cannot phosphorylate IkappaB-alpha directly, but it appears to be a functionally important subunit, because mutated NIK inhibited stimulus-induced kappaB-dependent transcription more effectively than mutated IKK-alpha or -beta.
T11 1684-1826 Sentence denotes Overexpression of IKK complex-associated protein inhibited stimulus-mediated transcription, whereas NF-kappaB essential modulator enhanced it.
T11 1684-1826 Sentence denotes Overexpression of IKK complex-associated protein inhibited stimulus-mediated transcription, whereas NF-kappaB essential modulator enhanced it.
T12 1827-1963 Sentence denotes The understanding of LPS- and TNF-induced signaling may allow the development of specific strategies to treat sepsis-associated disease.
T12 1827-1963 Sentence denotes The understanding of LPS- and TNF-induced signaling may allow the development of specific strategies to treat sepsis-associated disease.