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PubMed:10384153 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-82 Sentence denotes Altered memory T cell differentiation in patients with early rheumatoid arthritis.
T1 0-82 Sentence denotes Altered memory T cell differentiation in patients with early rheumatoid arthritis.
T2 83-253 Sentence denotes The chronic immune response in rheumatoid arthritis (RA) might be driven by activated Th1 cells without sufficient Th2 cell differentiation to down-modulate inflammation.
T2 83-253 Sentence denotes The chronic immune response in rheumatoid arthritis (RA) might be driven by activated Th1 cells without sufficient Th2 cell differentiation to down-modulate inflammation.
T3 254-548 Sentence denotes To test whether disordered memory T cell differentiation contributes to the typical Th1-dominated chronic inflammation in RA we investigated differentiation of resting CD4+ memory T cells in patients with early (6 wk to 12 mo) untreated RA and in age- and sex-matched healthy controls in vitro.
T3 254-548 Sentence denotes To test whether disordered memory T cell differentiation contributes to the typical Th1-dominated chronic inflammation in RA we investigated differentiation of resting CD4+ memory T cells in patients with early (6 wk to 12 mo) untreated RA and in age- and sex-matched healthy controls in vitro.
T4 549-672 Sentence denotes No difference in cytokine secretion profiles of freshly isolated memory T cells was detected between patients and controls.
T4 549-672 Sentence denotes No difference in cytokine secretion profiles of freshly isolated memory T cells was detected between patients and controls.
T5 673-814 Sentence denotes A cell culture system was then employed that permitted the differentiation of Th effectors from resting memory T cells by short term priming.
T5 673-814 Sentence denotes A cell culture system was then employed that permitted the differentiation of Th effectors from resting memory T cells by short term priming.
T6 815-868 Sentence denotes Marked differences were found in response to priming.
T6 815-868 Sentence denotes Marked differences were found in response to priming.
T7 869-977 Sentence denotes Th2 cells could be induced in all healthy controls by priming with anti-CD28 in the absence of TCR ligation.
T7 869-977 Sentence denotes Th2 cells could be induced in all healthy controls by priming with anti-CD28 in the absence of TCR ligation.
T8 978-1082 Sentence denotes By contrast, priming under those conditions resulted in Th2 differentiation in only 9 of 24 RA patients.
T8 978-1082 Sentence denotes By contrast, priming under those conditions resulted in Th2 differentiation in only 9 of 24 RA patients.
T9 1083-1226 Sentence denotes Exogenous IL-4 could overcome the apparent Th2 differentiation defect in seven patients but was without effect in the remaining eight patients.
T9 1083-1226 Sentence denotes Exogenous IL-4 could overcome the apparent Th2 differentiation defect in seven patients but was without effect in the remaining eight patients.
T10 1227-1437 Sentence denotes In all patients a marked decrease in IL-2-producing cells and a significant increase in well-differentiated Th1 cells that produced IFN-gamma but not IL-2 were evident after priming with anti-CD3 and anti-CD28.
T10 1227-1437 Sentence denotes In all patients a marked decrease in IL-2-producing cells and a significant increase in well-differentiated Th1 cells that produced IFN-gamma but not IL-2 were evident after priming with anti-CD3 and anti-CD28.
T11 1438-1732 Sentence denotes The data suggest that CD4+ memory T cells from patients with early untreated RA manifest an intrinsic abnormality in their ability to differentiate into specific cytokine-producing effector cells that might contribute to the characteristic Th1-dominated chronic (auto)immune inflammation in RA.
T11 1438-1732 Sentence denotes The data suggest that CD4+ memory T cells from patients with early untreated RA manifest an intrinsic abnormality in their ability to differentiate into specific cytokine-producing effector cells that might contribute to the characteristic Th1-dominated chronic (auto)immune inflammation in RA.