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PubMed:10367698 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
T1 0-109 Sentence denotes Binding characteristics of the glucocorticoid receptor in peripheral blood lymphocytes in multiple sclerosis.
T1 0-109 Sentence denotes Binding characteristics of the glucocorticoid receptor in peripheral blood lymphocytes in multiple sclerosis.
T2 110-255 Sentence denotes Although the exact etiology of multiple sclerosis (MS) remains unresolved, immune reactions are believed to be the central pathogenic mechanisms.
T2 110-255 Sentence denotes Although the exact etiology of multiple sclerosis (MS) remains unresolved, immune reactions are believed to be the central pathogenic mechanisms.
T3 256-479 Sentence denotes Endogenous and therapeutic steroid hormones affect the immune system, and inflammatory diseases are associated with activation of the hypothalamic-pituitary-adrenal axis, providing evidence of an immune-endocrine interplay.
T3 256-479 Sentence denotes Endogenous and therapeutic steroid hormones affect the immune system, and inflammatory diseases are associated with activation of the hypothalamic-pituitary-adrenal axis, providing evidence of an immune-endocrine interplay.
T4 480-614 Sentence denotes Function tests in MS have revealed dysregulation of the hypothalamic-pituitary-adrenal system in a substantial proportion of patients.
T4 480-614 Sentence denotes Function tests in MS have revealed dysregulation of the hypothalamic-pituitary-adrenal system in a substantial proportion of patients.
T5 615-888 Sentence denotes We characterized glucocorticoid receptor (GR) binding in peripheral blood lymphocytes from 39 MS patients and 14 age- and sex-matched controls with respect to dissociation constant and binding capacity, using a whole-cell binding assay with [3H]dexamethasone as the ligand.
T5 615-888 Sentence denotes We characterized glucocorticoid receptor (GR) binding in peripheral blood lymphocytes from 39 MS patients and 14 age- and sex-matched controls with respect to dissociation constant and binding capacity, using a whole-cell binding assay with [3H]dexamethasone as the ligand.
T6 889-1066 Sentence denotes GR binding parameters did not differ significantly between patients (Kd 8.98 +/- 1.07 nM, Bmax 183 +/- 29.8 fmol/mg) and controls (Kd 9.36 +/- 1.17 nM, Bmax 158 +/- 16 fmol/mg).
T6 889-1066 Sentence denotes GR binding parameters did not differ significantly between patients (Kd 8.98 +/- 1.07 nM, Bmax 183 +/- 29.8 fmol/mg) and controls (Kd 9.36 +/- 1.17 nM, Bmax 158 +/- 16 fmol/mg).
T7 1067-1172 Sentence denotes No effect of age, sex, course, duration or severity of disease, or prior steroid treatments was detected.
T7 1067-1172 Sentence denotes No effect of age, sex, course, duration or severity of disease, or prior steroid treatments was detected.
T8 1173-1375 Sentence denotes GR binding parameters were analyzed in relation to the results of the combined dexamethasone-CRH test, which reflects corticosteroid receptor function at the hypothalamus, in 30 patients and 9 controls.
T8 1173-1375 Sentence denotes GR binding parameters were analyzed in relation to the results of the combined dexamethasone-CRH test, which reflects corticosteroid receptor function at the hypothalamus, in 30 patients and 9 controls.
T9 1376-1543 Sentence denotes While controls showed a moderate correlation between binding affinity of the GR in lymphocytes and regulatory function at the hypothalamic level, the patients did not.
T9 1376-1543 Sentence denotes While controls showed a moderate correlation between binding affinity of the GR in lymphocytes and regulatory function at the hypothalamic level, the patients did not.
T10 1544-1678 Sentence denotes These data suggest that the physiological relationship between binding and function of the glucocorticoid receptor is disturbed in MS.
T10 1544-1678 Sentence denotes These data suggest that the physiological relationship between binding and function of the glucocorticoid receptor is disturbed in MS.