| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-194 |
Sentence |
denotes |
MEFV-Gene analysis in armenian patients with Familial Mediterranean fever: diagnostic value and unfavorable renal prognosis of the M694V homozygous genotype-genetic and therapeutic implications. |
| T1 |
0-194 |
Sentence |
denotes |
MEFV-Gene analysis in armenian patients with Familial Mediterranean fever: diagnostic value and unfavorable renal prognosis of the M694V homozygous genotype-genetic and therapeutic implications. |
| T2 |
195-314 |
Sentence |
denotes |
Familial Mediterranean fever (FMF) is a recessively inherited disorder that is common in patients of Armenian ancestry. |
| T2 |
195-314 |
Sentence |
denotes |
Familial Mediterranean fever (FMF) is a recessively inherited disorder that is common in patients of Armenian ancestry. |
| T3 |
315-524 |
Sentence |
denotes |
To date, its diagnosis, which can be made only retrospectively, is one of exclusion, based entirely on nonspecific clinical signs that result from serosal inflammation and that may lead to unnecessary surgery. |
| T3 |
315-524 |
Sentence |
denotes |
To date, its diagnosis, which can be made only retrospectively, is one of exclusion, based entirely on nonspecific clinical signs that result from serosal inflammation and that may lead to unnecessary surgery. |
| T4 |
525-663 |
Sentence |
denotes |
Renal amyloidosis, prevented by colchicine, is the most severe complication of FMF, a disorder associated with mutations in the MEFV gene. |
| T4 |
525-663 |
Sentence |
denotes |
Renal amyloidosis, prevented by colchicine, is the most severe complication of FMF, a disorder associated with mutations in the MEFV gene. |
| T5 |
664-859 |
Sentence |
denotes |
To evaluate the diagnostic and prognostic value of MEFV-gene analysis, we investigated 90 Armenian FMF patients from 77 unrelated families that were not selected through genetic-linkage analysis. |
| T5 |
664-859 |
Sentence |
denotes |
To evaluate the diagnostic and prognostic value of MEFV-gene analysis, we investigated 90 Armenian FMF patients from 77 unrelated families that were not selected through genetic-linkage analysis. |
| T6 |
860-1028 |
Sentence |
denotes |
Eight mutations, one of which (R408Q) is new, were found to account for 93% of the 163 independent FMF alleles, with both FMF alleles identified in 89% of the patients. |
| T6 |
860-1028 |
Sentence |
denotes |
Eight mutations, one of which (R408Q) is new, were found to account for 93% of the 163 independent FMF alleles, with both FMF alleles identified in 89% of the patients. |
| T7 |
1029-1177 |
Sentence |
denotes |
In several instances, family studies provided molecular evidence for pseudodominant transmission and incomplete penetrance of the disease phenotype. |
| T7 |
1029-1177 |
Sentence |
denotes |
In several instances, family studies provided molecular evidence for pseudodominant transmission and incomplete penetrance of the disease phenotype. |
| T8 |
1178-1361 |
Sentence |
denotes |
The M694V homozygous genotype was found to be associated with a higher prevalence of renal amyloidosis and arthritis, compared with other genotypes (P=.0002 and P=.006, respectively). |
| T8 |
1178-1361 |
Sentence |
denotes |
The M694V homozygous genotype was found to be associated with a higher prevalence of renal amyloidosis and arthritis, compared with other genotypes (P=.0002 and P=.006, respectively). |
| T9 |
1362-1599 |
Sentence |
denotes |
The demonstration of both the diagnostic and prognostic value of MEFV analysis and particular modes of inheritance should lead to new ways for management of FMF-including genetic counseling and therapeutic decisions in affected families. |
| T9 |
1362-1599 |
Sentence |
denotes |
The demonstration of both the diagnostic and prognostic value of MEFV analysis and particular modes of inheritance should lead to new ways for management of FMF-including genetic counseling and therapeutic decisions in affected families. |
