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PubMed:10359894 JSONTXT 10 Projects

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Id Subject Object Predicate Lexical cue
T1 0-97 Sentence denotes Effects of diesel organic extracts on chemokine production by peripheral blood mononuclear cells.
T1 0-97 Sentence denotes Effects of diesel organic extracts on chemokine production by peripheral blood mononuclear cells.
T2 98-109 Sentence denotes BACKGROUND:
T2 98-109 Sentence denotes BACKGROUND:
T3 110-236 Sentence denotes Polyaromatic hydrocarbons (PAHs) associated with diesel exhaust particles (DEPs) are found in the atmospheric urban pollution.
T3 110-236 Sentence denotes Polyaromatic hydrocarbons (PAHs) associated with diesel exhaust particles (DEPs) are found in the atmospheric urban pollution.
T4 237-348 Sentence denotes Such compounds have been shown to favor IgE production, bronchial hyperresponsiveness, and airway inflammation.
T4 237-348 Sentence denotes Such compounds have been shown to favor IgE production, bronchial hyperresponsiveness, and airway inflammation.
T5 349-447 Sentence denotes Chemokines are a group of chemotactic cytokines involved in the recruitment of inflammatory cells.
T5 349-447 Sentence denotes Chemokines are a group of chemotactic cytokines involved in the recruitment of inflammatory cells.
T6 448-458 Sentence denotes OBJECTIVE:
T6 448-458 Sentence denotes OBJECTIVE:
T7 459-600 Sentence denotes We investigated the effect of DEP-PAHs on the release and mRNA expression of IL-8, MCP-1, and RANTES by PBMCs obtained from healthy subjects.
T7 459-600 Sentence denotes We investigated the effect of DEP-PAHs on the release and mRNA expression of IL-8, MCP-1, and RANTES by PBMCs obtained from healthy subjects.
T8 601-609 Sentence denotes METHODS:
T8 601-609 Sentence denotes METHODS:
T9 610-729 Sentence denotes Protein production in supernatants was assessed by ELISA, and mRNA expression was evaluated by semiquantitative RT-PCR.
T9 610-729 Sentence denotes Protein production in supernatants was assessed by ELISA, and mRNA expression was evaluated by semiquantitative RT-PCR.
T10 730-738 Sentence denotes RESULTS:
T10 730-738 Sentence denotes RESULTS:
T11 739-876 Sentence denotes Secretion of IL-8 and RANTES increased in a dose-dependent manner with increasing concentrations of DEP-PAHs (range, 0.5 ng to 50 ng/mL).
T11 739-876 Sentence denotes Secretion of IL-8 and RANTES increased in a dose-dependent manner with increasing concentrations of DEP-PAHs (range, 0.5 ng to 50 ng/mL).
T12 877-976 Sentence denotes On the contrary, the release of MCP-1 was significantly inhibited, also in a dose-dependent manner.
T12 877-976 Sentence denotes On the contrary, the release of MCP-1 was significantly inhibited, also in a dose-dependent manner.
T13 977-1112 Sentence denotes Messenger RNA production coding for IL-8, RANTES, and MCP-1 showed parallel variations to the production of the correspondent proteins.
T13 977-1112 Sentence denotes Messenger RNA production coding for IL-8, RANTES, and MCP-1 showed parallel variations to the production of the correspondent proteins.
T14 1113-1258 Sentence denotes Effects of DEP-PAHs became significant at 7 hours and up to 48 hours time culture for MCP-1, and up to 24 hours time culture for IL-8 and RANTES.
T14 1113-1258 Sentence denotes Effects of DEP-PAHs became significant at 7 hours and up to 48 hours time culture for MCP-1, and up to 24 hours time culture for IL-8 and RANTES.
T15 1259-1553 Sentence denotes Moreover, supernatants from DEP-PAH-activated cells, compared with those of controls, exhibited a significantly enhanced chemotactic activity for neutrophils and eosinophils, which was significantly inhibited by pretreatment with anti-IL-8 and anti-RANTES neutralizing antibodies, respectively.
T15 1259-1553 Sentence denotes Moreover, supernatants from DEP-PAH-activated cells, compared with those of controls, exhibited a significantly enhanced chemotactic activity for neutrophils and eosinophils, which was significantly inhibited by pretreatment with anti-IL-8 and anti-RANTES neutralizing antibodies, respectively.
T16 1554-1565 Sentence denotes CONCLUSION:
T16 1554-1565 Sentence denotes CONCLUSION:
T17 1566-1786 Sentence denotes These findings suggest that the chemokine pathways are modulated by DEP-PAHs at the transcriptional level, reinforcing the idea that the development of inflammatory reactions might be affected by diesel exhaust emission.
T17 1566-1786 Sentence denotes These findings suggest that the chemokine pathways are modulated by DEP-PAHs at the transcriptional level, reinforcing the idea that the development of inflammatory reactions might be affected by diesel exhaust emission.