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PubMed:10352279 JSONTXT 12 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-152 Sentence denotes CD28 costimulation augments IL-2 secretion of activated lamina propria T cells by increasing mRNA stability without enhancing IL-2 gene transactivation.
T1 0-152 Sentence denotes CD28 costimulation augments IL-2 secretion of activated lamina propria T cells by increasing mRNA stability without enhancing IL-2 gene transactivation.
T2 153-257 Sentence denotes The pathways leading to activation in lamina propria (LP) T cells are different from peripheral T cells.
T2 153-257 Sentence denotes The pathways leading to activation in lamina propria (LP) T cells are different from peripheral T cells.
T3 258-340 Sentence denotes LP T cells exhibit enhanced IL-2 secretion when activated through the CD2 pathway.
T3 258-340 Sentence denotes LP T cells exhibit enhanced IL-2 secretion when activated through the CD2 pathway.
T4 341-411 Sentence denotes Coligation of CD28 leads to synergistic enhancement of IL-2 secretion.
T4 341-411 Sentence denotes Coligation of CD28 leads to synergistic enhancement of IL-2 secretion.
T5 412-646 Sentence denotes Previous studies have characterized the CD28 augmentation of TCR-mediated signaling in peripheral blood T cells through transcriptional activation of an IL-2 promoter CD28 response element (CD28RE), along with enhanced mRNA stability.
T5 412-646 Sentence denotes Previous studies have characterized the CD28 augmentation of TCR-mediated signaling in peripheral blood T cells through transcriptional activation of an IL-2 promoter CD28 response element (CD28RE), along with enhanced mRNA stability.
T6 647-770 Sentence denotes This study characterized molecular events involved in CD28 costimulation of IL-2 production in LP mononuclear cells (LPMC).
T6 647-770 Sentence denotes This study characterized molecular events involved in CD28 costimulation of IL-2 production in LP mononuclear cells (LPMC).
T7 771-895 Sentence denotes LPMC exhibited increased IL-2 production in response to CD28 costimulation, compared with cells activated through CD2 alone.
T7 771-895 Sentence denotes LPMC exhibited increased IL-2 production in response to CD28 costimulation, compared with cells activated through CD2 alone.
T8 896-1008 Sentence denotes IL-2 secretion was paralleled by increased expression of IL-2 mRNA, resulting from enhanced IL-2 mRNA stability.
T8 896-1008 Sentence denotes IL-2 secretion was paralleled by increased expression of IL-2 mRNA, resulting from enhanced IL-2 mRNA stability.
T9 1009-1289 Sentence denotes In contrast to transcriptional activation in PBMC, EMSA revealed that CD28 coligation of CD2-activated LPMC does not result in increased binding of trans-factors to the CD28RE, nor did Western blots detect changes in I-kappaBalpha or I-kappaBbeta levels following CD28 coligation.
T9 1009-1289 Sentence denotes In contrast to transcriptional activation in PBMC, EMSA revealed that CD28 coligation of CD2-activated LPMC does not result in increased binding of trans-factors to the CD28RE, nor did Western blots detect changes in I-kappaBalpha or I-kappaBbeta levels following CD28 coligation.
T10 1290-1411 Sentence denotes Furthermore, CD28 coligation fails to enhance IL-2 promoter-reporter or RE/AP construct expression in CD2-activated LPMC.
T10 1290-1411 Sentence denotes Furthermore, CD28 coligation fails to enhance IL-2 promoter-reporter or RE/AP construct expression in CD2-activated LPMC.
T11 1412-1641 Sentence denotes The results reported herein indicate that the molecular mechanisms involved in CD28 cosignaling and regulation of IL-2 secretion in LP T cells are unique to that compartment and differ from those seen in peripheral blood T cells.
T11 1412-1641 Sentence denotes The results reported herein indicate that the molecular mechanisms involved in CD28 cosignaling and regulation of IL-2 secretion in LP T cells are unique to that compartment and differ from those seen in peripheral blood T cells.
T12 1642-1816 Sentence denotes These observations suggest a biological significance for different mechanisms of IL-2 activation in initiation and maintenance of the cytokine repertoire found in the mucosa.
T12 1642-1816 Sentence denotes These observations suggest a biological significance for different mechanisms of IL-2 activation in initiation and maintenance of the cytokine repertoire found in the mucosa.